Evaluation of Different Smoking Cessation Protocols: Nicotine Replacement, Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy in Cancer Patients Scheduled for Surgery

NCT ID: NCT04899492

Last Updated: 2024-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-09-29

Study Completion Date

2024-03-29

Brief Summary

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This trial offers support and assistance to patients wishing to quit smoking in order to increase the success rate of smoking cessation and all the benefits associated with it. Patients will be monitored by a tobacco specialist and will be able to benefit from one or more therapies complementary to Nicotine Replacement Therapy (NRT): Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy.

Detailed Description

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The study RESPIRE is aiming to identify some interventions to be proposed as part of a smoking cessation programme for smokers with cancer requiring surgical treatment and wishing to stop smoking. We aim to compare different smoking cessation methods in addition to the currently recommended treatments: Nicotine Replacement Therapy (NRT). These procedures are: Cognitive Behavioural Therapy (CBT), Motivational Interviewing (MI) or hypnotherapy in order to improve the success rate of smoking cessation in this specific population.

All patients wishing to be supported to stop smoking will be randomized and will be followed by a tobacco specialist before and after surgery. They will receive NRT for 12 months.

Smoking assessment, exhaled CO measurement, questionnaires will be completed regularly to assess depression, anxiety and quality of life during the 12 months.

Patients randomized in group 2 will receive 1 to 3 MI. Patients randomized in group 3 will receive 1 to 3 MI and 6 CBT sessions by a psychotherapist.

Patients randomized in group 4 will receive 1 to 3 MI and at least 3 sessions oh hypnotherapy.

Conditions

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Breast Cancer Gynecologic Cancer Digestive Cancer Melanoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

pilot study, monocentric, prospective, randomization according to Zelen's design
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group 1:Nicotine Replacement Therapy (NRT)

Patients enrolled in group 1 will receive a Nicotine Replacement Therapy (NRT) from the study entry to end of study

Group Type ACTIVE_COMPARATOR

Nicotine Replacement Therapy (NRT)

Intervention Type DRUG

All patients will receive Nicotine Replacement Therapy (NRT) from randomization up to 6 months

Group 2:Motivational Interviewing (MI)

Patients enrolled in group 2 will receive a Nicotine Replacement Therapy (NRT) from the study entry to end of study and 1 to 3 Motivational Interviewing (MI) after randomization

Group Type EXPERIMENTAL

Motivational Interviewing (MI)

Intervention Type BEHAVIORAL

1 to 3 Motivational Interviewing (MI) should be performed after randomization by a psychotherapist

Nicotine Replacement Therapy (NRT)

Intervention Type DRUG

All patients will receive Nicotine Replacement Therapy (NRT) from randomization up to 6 months

Group 3:Cognitive Behavioural Therapy (CBT)

Patients enrolled in group 3 will receive a Nicotine Replacement Therapy (NRT) from the study entry to end of study and 1 to 3 Motivational Interviewing (MI) after randomization and 6 sessions of CBT after Motivational Interviewing up to 6 months after

Group Type EXPERIMENTAL

Motivational Interviewing (MI)

Intervention Type BEHAVIORAL

1 to 3 Motivational Interviewing (MI) should be performed after randomization by a psychotherapist

Cognitive Behavioural Therapy (CBT)

Intervention Type BEHAVIORAL

6 Cognitive Behavioural Therapy (CBT) sessions should be performed after motivational interviewing up to 6 months by a psychotherapist

Nicotine Replacement Therapy (NRT)

Intervention Type DRUG

All patients will receive Nicotine Replacement Therapy (NRT) from randomization up to 6 months

Group 4: Hypnotherapy

Patients enrolled in group 4 will receive a Nicotine Replacement Therapy (NRT) from the study entry to end of study and 1 to 3 Motivational Interviewing (MI) after randomization and about 3 sessions of hypnotherapy up to 6 months after

Group Type EXPERIMENTAL

Motivational Interviewing (MI)

Intervention Type BEHAVIORAL

1 to 3 Motivational Interviewing (MI) should be performed after randomization by a psychotherapist

Hypnotherapy

Intervention Type BEHAVIORAL

About 3 Hypnotherapy sessions should be performed after motivational interviewing up to 6 months by a hypnotherapist

Nicotine Replacement Therapy (NRT)

Intervention Type DRUG

All patients will receive Nicotine Replacement Therapy (NRT) from randomization up to 6 months

Interventions

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Motivational Interviewing (MI)

1 to 3 Motivational Interviewing (MI) should be performed after randomization by a psychotherapist

Intervention Type BEHAVIORAL

Cognitive Behavioural Therapy (CBT)

6 Cognitive Behavioural Therapy (CBT) sessions should be performed after motivational interviewing up to 6 months by a psychotherapist

Intervention Type BEHAVIORAL

Hypnotherapy

About 3 Hypnotherapy sessions should be performed after motivational interviewing up to 6 months by a hypnotherapist

Intervention Type BEHAVIORAL

Nicotine Replacement Therapy (NRT)

All patients will receive Nicotine Replacement Therapy (NRT) from randomization up to 6 months

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years.
* Smoking patient: daily tobacco consumption.
* Patient with cancer requiring surgical treatment (breast cancer, digestive cancer, gynecological).
* Patient wishing to quit smoking.
* Fagerström \> 3.
* Patient has valid health insurance
* Information and agreement of the patient to participate in the longitudinal cohort.
* Signing of specific informed consent for patients in groups 1 to 4 before any study-related intervention.
* Person able to speak, read and understand French.

Exclusion Criteria

* Patient not receiving surgical treatment.
* Refusal to participate in the longitudinal cohort study.
* Pregnant or likely to be pregnant or nursing patient.
* Persons deprived of their liberty, under a measure of safeguard of justice, under guardianship or placed under the authority of a guardian
* disability to undergo the medical follow-up of the trial for geographical, social or psychological reasons.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Cancer Institute, France

OTHER_GOV

Sponsor Role collaborator

Institut Cancerologie de l'Ouest

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Institut de Cancerologie de l'Ouest (ICO)

Saint-Herblain, , France

Site Status

Countries

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France

Other Identifiers

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ICO-2020-14

Identifier Type: -

Identifier Source: org_study_id

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