Trial Outcomes & Findings for The Impact of Serial Remote Ischemic Conditioning on Dynamic Cerebral Autoregulation in Healthy Adults (NCT NCT04899362)

Results Overview

Dynamic cerebral autoregulation (dCA) is an important indicator of cerebrovascular function which related to the prognosis of cerebrovascular disease. DCA is usually calculated by transfer function analysis. Phase Difference (PD) is gengreated. Low PD at a low frequency band indicates impairment of autoregulation, as it suggests that cerebral blood flow velocity follows the changes in arterial blood pressure with a short delay.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

36 participants

Primary outcome timeframe

36 days

Results posted on

2024-01-03

Participant Flow

Participant milestones

Participant milestones
Measure	RIC Group RIC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take 14 RIC intervention, blood collection and 10 dCA measurements.
Overall Study STARTED	36
Overall Study COMPLETED	22
Overall Study NOT COMPLETED	14

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Race and Ethnicity were not collected from any participant.

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	RIC Group n=22 Participants RIC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take 14 RIC intervention, blood collection and 10 dCA measurements.
Age, Continuous	25.73 years STANDARD_DEVIATION 1.78 • n=22 Participants
Sex: Female, Male Female	19 Participants n=22 Participants
Sex: Female, Male Male	3 Participants n=22 Participants
Height	164.50 cm STANDARD_DEVIATION 8.36 • n=22 Participants
Weight	56.81 kg STANDARD_DEVIATION 9.42 • n=22 Participants
BMI	20.88 kg/m^2 STANDARD_DEVIATION 2.10 • n=22 Participants

PRIMARY outcome

Timeframe: 36 days

Dynamic cerebral autoregulation (dCA) is an important indicator of cerebrovascular function which related to the prognosis of cerebrovascular disease. DCA is usually calculated by transfer function analysis. Phase Difference (PD) is gengreated. Low PD at a low frequency band indicates impairment of autoregulation, as it suggests that cerebral blood flow velocity follows the changes in arterial blood pressure with a short delay.

Outcome measures

Outcome measures
Measure	RIC Group n=22 Participants RIC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take 14 RIC intervention, blood collection and 10 dCA measurements.
Dynamic Cerebral Autoregulation Parameter: Phase Difference(PD) in Degree	45.87 degree Standard Deviation 13.02

SECONDARY outcome

Timeframe: 36 days

High gain at the same frequency band is also considered an indicator of compromised autoregulation for passively transferring the amplitude of arterial blood pressure to cerebral blood flow velocity.

Outcome measures

Outcome measures
Measure	RIC Group n=22 Participants RIC was induced by 4 cycles of extremities ischemia (5-minute blood-pressure cuff inflation to 200 mm Hg, followed by 5-minute cuff deflation).All subjects will take 14 RIC intervention, blood collection and 10 dCA measurements.
Dynamic Cerebral Autoregulation Parameter: Gain in cm/s/mmHg	0.95 cm/s/mmHg Standard Deviation 0.25

Adverse Events

RIC Group

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr Yi Yang

the First Hospital of Jilin University

Phone: 0431

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place