Social Relationships and Accelerated Aging in Hematopoietic Cell Transplant Survivors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

110 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-18

Study Completion Date

2026-05-31

Brief Summary

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This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.

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Detailed Description

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PRIMARY OBJECTIVES:

I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period.

II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period.

III. Test biological aging as a mediator linking social processes and phenotypic aging.

EXPLORATORY OBJECTIVE:

I. Test sex differences in Aims 1 and 2.

OUTLINE:

Adopting a prospective design, participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives16. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome-wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Conditions

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Hematopoietic and Lymphoid Cell Neoplasm

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Supportive care (EAR, questionnaires, biospecimen collection)

Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.

Biospecimen Collection

Intervention Type PROCEDURE

Undergo collection of blood sample

Electronic Health Record Review

Intervention Type OTHER

Review of medical records

Questionnaire Administration

Intervention Type OTHER

Complete questionnaires

Interventions

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Biospecimen Collection

Undergo collection of blood sample

Intervention Type PROCEDURE

Electronic Health Record Review

Review of medical records

Intervention Type OTHER

Questionnaire Administration

Complete questionnaires

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 18 years and older who are competent to give their informed consent.
* Ability to read, speak, and understand English.
* Received a hematopoietic cell transplant within the previous 100 days.

Exclusion Criteria

* Less then Aged 18 years and older who are competent to give their informed consent.
* Cannot read, speak, and understand English.
* Has not received a hematopoietic cell transplant within the previous 100 days.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No