Feasibility and Preliminary Effects of MR-005 in Persons With Parkinson Disease

NCT ID: NCT04891107

Last Updated: 2023-12-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-07-02

Study Completion Date

2022-06-08

Brief Summary

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The purpose of this clinical study is to evaluate the effects of music, tailored to the participant's cadence, on adherence, quality of life, gait speed, functional mobility, and walking activity in individuals with Parkinson disease when used in the home and community environment.

Detailed Description

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Persons with Parkinson disease will be enrolled to determine the effects of a community walking program with a music-based device on adherence, quality of life, walking speed and walking activity. The walking program will be carried out independently by participants in their home/community environment. Noninvasive functional assessments commonly administered in clinical practice will be used to measure the variables of interest.

Conditions

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Parkinson Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Walking Program with a Music-based, Rhythm-modulating Wearable Sensor System

Group Type EXPERIMENTAL

Walking Program with a Music-based, Rhythm-modulating Wearable Sensor System

Intervention Type DEVICE

Participants will walk using the music-based, rhythm-modulating wearable sensor system (foot sensors, mobile device with mobile app and headphones) for thirty (30) minutes at a time, 5 times a week for 4 weeks.

Interventions

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Walking Program with a Music-based, Rhythm-modulating Wearable Sensor System

Participants will walk using the music-based, rhythm-modulating wearable sensor system (foot sensors, mobile device with mobile app and headphones) for thirty (30) minutes at a time, 5 times a week for 4 weeks.

Intervention Type DEVICE

Other Intervention Names

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MedRhythms MR-005 Device

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of idiopathic, typical Parkinson disease.
* Modified Hoehn and Yahr stages 1-3 per physical exam.
* Able to walk independently without physical assistance or an assistive device.

Exclusion Criteria

* Diagnosis of atypical Parkinsonism.
* Moderately or significantly disturbing freezing episodes during daily walking.
* Cognitive impairment as determined by the Montreal Cognitive Assessment (MoCA).
* Significant hearing impairment.
* Currently participating in physical therapy.
* Cardiac problems that interfere with the ability to safely exercise.
* Orthopedic problems in the lower extremities or spine that may limit walking distance.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johns Hopkins University

OTHER

Sponsor Role collaborator

Boston University

OTHER

Sponsor Role collaborator

MedRhythms, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Terry Ellis, PT, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

College of Health & Rehabilitation Sciences: Sargent College

Alex Pantelyat, M.D.

Role: PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Locations

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Johns Hopkins University School of Medicine

Baltimore, Maryland, United States

Site Status

Boston University College of Health & Rehabilitation: Sargent College

Boston, Massachusetts, United States

Site Status

Countries

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United States

References

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Zajac JA, Porciuncula F, Cavanaugh JT, McGregor C, Harris BA, Smayda KE, Awad LN, Pantelyat A, Ellis TD. Feasibility and Proof-of-Concept of Delivering an Autonomous Music-Based Digital Walking Intervention to Persons with Parkinson's Disease in a Naturalistic Setting. J Parkinsons Dis. 2023;13(7):1253-1265. doi: 10.3233/JPD-230169.

Reference Type DERIVED
PMID: 37840504 (View on PubMed)

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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CM082000501

Identifier Type: -

Identifier Source: org_study_id