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Investigation of Dynamic Hyperinflation and Its Relationship With Functional Exercise Capacity in Children With Bronchiectasis

NCT ID: NCT04885790

Last Updated: 2021-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-06-01

Study Completion Date

2021-08-10

Brief Summary

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Prevalence of dynamic hyperinflation and its relationship with functional exercise capacity will be evaluated in children with bronchiectasis.

Detailed Description

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Exercise or hyperpnea-induced air trapping is referred to as dynamic hyperinflation. In the presence of high resistance to expiratory flows and short expiratory times, the respiratory system is unable to return to its resting volume at the end of exhalation. The positive pressure within regions of hyperinflated lung raises the mean intrathoracic pressure and causes the inspiratory muscles to operate at a higher than resting lung volume. Thus, dynamic hyperinflation places the respiratory muscles at a considerable mechanical disadvantage and further impairs respiratory function. Dynamic hyperinflation is considered to be a key determinant of exercise capacity in patients with obstructive lung diseases. Although bronchiectasis is one of the obstructive lung diseases, the presence of dynamic hyperinflation in these patients has not been adequately investigated. Management guidelines of bronchiectasis state that imaging methods or pulmonary function tests alone is not sufficient to determine the disease burden and prognosis in these patients, so they recommend including detailed evaluation of exercise tolerance in the management of bronchiectasis. Aim of this study is to investigate the prevalence of dynamic hyperinflation and its relationship with functional exercise capacity in children with bronchiectasis.

Conditions

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Bronchiectasis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Bronchiectasis

Children with bronchiectasis

Respiratory assessment using "Spiropalm 6MWT" portable spirometry

Intervention Type OTHER

"Spiropalm 6MWT" portable spirometry will be used during six-minute walk test for evaluation of dynamic hyperinflation and other related ventilatory parameters. The device will also be used as regular spirometry.

Evaluation of functional exercise capacity

Intervention Type OTHER

Functional exercise capacity of patients will be evaluated using six-minute walk test.

Evaluation of peripheral muscle strength

Intervention Type OTHER

Handgrip strength and M. Quadriceps strength will be evaluated using hand-held dynamometer.

Evaluation of chronic cough

Intervention Type OTHER

The Leicester Cough Questionnaire will be used for evaluating cough.

Interventions

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Respiratory assessment using "Spiropalm 6MWT" portable spirometry

"Spiropalm 6MWT" portable spirometry will be used during six-minute walk test for evaluation of dynamic hyperinflation and other related ventilatory parameters. The device will also be used as regular spirometry.

Intervention Type OTHER

Evaluation of functional exercise capacity

Functional exercise capacity of patients will be evaluated using six-minute walk test.

Intervention Type OTHER

Evaluation of peripheral muscle strength

Handgrip strength and M. Quadriceps strength will be evaluated using hand-held dynamometer.

Intervention Type OTHER

Evaluation of chronic cough

The Leicester Cough Questionnaire will be used for evaluating cough.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of bronchiectasis

Exclusion Criteria

* Hospitalization history during past month
* Diagnosis of any other chronic childhood diseases such as cerebral palsy or neuromuscular diseases which may impede exercise tolerance
Minimum Eligible Age

8 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ege University

OTHER

Sponsor Role collaborator

Izmir Bakircay University

OTHER

Sponsor Role lead

Responsible Party

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Melih Zeren

Assist. Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ege University Faculty of Medicine, Department of Pediatrics, Division of Pediatric Pulmonology

Izmir, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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bakircaymzeren03

Identifier Type: -

Identifier Source: org_study_id