Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Multiple Ascending Doses of Oral WCK 2349

NCT ID: NCT04874324

Last Updated: 2022-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-03-17

Study Completion Date

2011-06-25

Brief Summary

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The present study is planned to assess the safety, tolerability and pharmacokinetic profile of WCK 2349 in US subjects with selected ascending multiple doses of WCK 2349 and to compare the safety, tolerability and pharmacokinetic data with the data observed in similar studies conducted in India.

Detailed Description

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Conditions

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Pharmacokinetics

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SEQUENTIAL

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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WCK 2349

WCK 2349 800mg, 1000mg, and 1200mg . 1 dose given orally twice daily at 12 hourly interval for five days.

Dosage form : Oral

Group Type EXPERIMENTAL

WCK 2349 Oral

Intervention Type DRUG

1 dose given orally twice daily at 12 hourly interval for five days.

Placebo

Matching Placebo administered as Oral

Group Type PLACEBO_COMPARATOR

Placebo Oral

Intervention Type OTHER

Subjects will receive matching placebo

Interventions

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WCK 2349 Oral

1 dose given orally twice daily at 12 hourly interval for five days.

Intervention Type DRUG

Placebo Oral

Subjects will receive matching placebo

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Must be healthy males or non-pregnant females
* Have a Body Mass Index (BMI) between 18 and 32 (both inclusive), calculated as weight in kg / height in m2
* Have no significant diseases or clinically significant abnormal findings during screening, medical history, physical examination, laboratory evaluations and ECG recordings.
* Should test negative for drugs of abuse and urine alcohol test.

Exclusion Criteria

* Known hypersensitivity or idiosyncratic reaction to quinolones or any other related drugs.
* Any history or evidence of disease or condition which might compromise the haemopoietic, renal, hepatic, endocrine, pulmonary, central nervous, cardiovascular, immunological, dermatological, gastrointestinal or any other body system.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Wockhardt

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ashima Bhatia, MD

Role: STUDY_DIRECTOR

Wockhardt Ltd

Other Identifiers

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WCK 2349/ P-I/ MD/ 08

Identifier Type: -

Identifier Source: org_study_id

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