Sensor-based Assessment and Rehabilitation of Balance in Neurological Diseases

NCT ID: NCT04874051

Last Updated: 2023-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-02

Study Completion Date

2023-12-31

Brief Summary

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Balance impairment is one of the most common disorders due to a neurological diseases. Sensor-based technologies may be useful for falls prevention and balance recovery during patients hospitalization. OAK Elderly Care System (Khymeia Group, Noventa Padovana, Italy) allows the assessment of fall risk, the centre of pressure and the execution of balance exercises in a virtual environment.

Detailed Description

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The aim of the study is to compare the therapy provided by means of the OAK Elderly Care System with conventional physiotherapy for balance rehabilitation in patients affected by stroke, Multiple Sclerosis (MS) and Parkinson Disease (PD).

OAK Elderly Care System consists of two independent balance boards and three sensors for the kinematic tracking of the trunk and lower limbs. These components allow the assessment of the centre of pressure and the execution of exercises in a virtual environment.

120 patients (40 stroke, 40 MS, 40 PK) hospitalized at 4 different italian hospitals, were enrolled according to inclusion and exclusion criteria and randomly assigned to two groups (i.e. intervention group, control group). Intervention group received 1 daily hour of technology-based treatment, while the control group underwent 1 daily hour of physiotherapy for balance rehabilitation, in addiction to 1 hour of conventional physiotherapy. Both treatments lasted 15 sessions. Before and after treatment balance, walking, daily living autonomy and pathology-specific features were assessed.

Conditions

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Stroke Multiple Sclerosis Parkinson Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The experimental group is treated through a sensor-based devices in a virtual environment, while the control group is treated through conventional physiotherapy for balance rehabilitation
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Experimental Group (EG)

In the EG the subjects will perform balance exercises using the OAK system under the supervision of a trained physiotherapist. The treatment will last 3 weeks with daily sessions of 60 minutes, 5 times per week.

Group Type EXPERIMENTAL

Experimental Group

Intervention Type DEVICE

The experimental treatment will be provided by means of the OAK system. This device consists of 1 cabinet with 2 independent balance boards, 2 monitors (one for the physiotherapist and one for the patient) and 3 wireless IMUs (one for the left lower limb, one for the right lower limb and one for the trunk). The 2 balance boards provide body weight transfer exercises, while the wireless motion sensors provide one leg stance exercises or trunk exercises in a virtual environment.

Control Group (CG)

In the CG the subjects will be asked to perform conventional balance exercises under the supervision of a physiotherapist. The treatment will last 3 weeks with daily sessions of 60 minutes, 5 times per week.

Group Type ACTIVE_COMPARATOR

Control Group

Intervention Type OTHER

The Control Group will perform conventional balance exercises similar to the exercises provided with the OAK system.

Interventions

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Experimental Group

The experimental treatment will be provided by means of the OAK system. This device consists of 1 cabinet with 2 independent balance boards, 2 monitors (one for the physiotherapist and one for the patient) and 3 wireless IMUs (one for the left lower limb, one for the right lower limb and one for the trunk). The 2 balance boards provide body weight transfer exercises, while the wireless motion sensors provide one leg stance exercises or trunk exercises in a virtual environment.

Intervention Type DEVICE

Control Group

The Control Group will perform conventional balance exercises similar to the exercises provided with the OAK system.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Common criteria:

* Berg Balance Scale \< 50/56;
* Ability to maintain the standing position with o without one support for 1 minute;
* Functional Independence measure \< 100/126;
* Barthel Index \< 80/100.

Stroke:

* Single ischemic stroke;
* Lesion occured after 2 and within 18 months;
* National Institute of Health Stroke Scale ≤ 14.

Parkinson:

* 1.5 \< Hoehn \& Yahr \< 3;
* Subitem "freezing when walking"of the UPDRS ≤ 2.

Multiple Sclerosis:

* Relapsing remitting or secondary progressive Multiple Sclerosis;
* Expanded Disability Status Scale ≤ 6.5.

Exclusion Criteria

* Untreated epilepsy;
* Major depressive disorder;
* Fractures;
* Dementia;
* Ideomotor Apraxia;
* Neglect;
* Severe impairment of verbal comprehension;
* Severe acoustic and visual disorders.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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IRCCS San Raffaele

OTHER

Sponsor Role collaborator

Istituti Clinici Scientifici Maugeri SpA

OTHER

Sponsor Role collaborator

IRCCS National Neurological Institute "C. Mondino" Foundation

OTHER

Sponsor Role collaborator

I.R.C.C.S. Fondazione Santa Lucia

OTHER

Sponsor Role collaborator

IRCCS San Camillo, Venezia, Italy

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrea Turolla, PhD

Role: PRINCIPAL_INVESTIGATOR

San Camillo IRCCS

Locations

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IRCCS Fondazione Mondino

Pavia, , Italy

Site Status RECRUITING

IRCCS ICS Maugeri Spa SB

Pavia, , Italy

Site Status RECRUITING

IRCCS San Raffaele Pisana

Rome, , Italy

Site Status RECRUITING

IRCCS Fondazione Santa Lucia

Rome, , Italy

Site Status RECRUITING

San Camillo IRCCS

Venice, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Andrea Turolla, PhD

Role: CONTACT

00390412207 ext. 531

Facility Contacts

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Cristina Tassorelli, Prof.

Role: primary

0382380425

Giorgio Maggioni, Dr.

Role: primary

0322884711

Marco Franceschini, Dr.

Role: primary

Role: backup

06660581

Giovanni Morone, Dr.

Role: primary

Other Identifiers

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1099/IRCCS San Camillo

Identifier Type: -

Identifier Source: org_study_id

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