A Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for Participants With HER2-Positive Breast Cancer at High Risk of Recurrence Following Preoperative Therapy

NCT ID: NCT04873362

Last Updated: 2025-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

1188 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-04

Study Completion Date

2034-10-02

Brief Summary

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This is a Phase III, two-arm, randomized, double-blind placebo-controlled study in participants with HER2-positive primary breast cancer who have received preoperative chemotherapy and HER2-directed therapy, including trastuzumab followed by surgery, with a finding of residual invasive disease in the breast and/or axillary lymph nodes.

As of June 4, 2024, this study is no longer accepting any newly screened participants.

Detailed Description

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Conditions

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Breast Cancer

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Arm A: Placebo + Trastuzumab Emtansine

Participants will receive an intravenous (IV) infusion of placebo prior to the IV infusion of trastuzumab emtansine on Day 1 of each 21-day cycle for a total of 14 cycles.

Group Type ACTIVE_COMPARATOR

Trastuzumab Emtansine

Intervention Type DRUG

Trastuzumab emtansine will be administered at a dose of 3.6 mg/kg Q3W for 14 weeks.

Placebo

Intervention Type DRUG

Placebo matched to atezolizumab will be administered at a dose of 1200 mg Q3W for 14 cycles.

Trastuzumab

Intervention Type DRUG

Trastuzumab will be used to complete 14 cycles of study treatment if trastuzumab emtansine is discontinued for toxicity not considered to be related to the trastuzumab component of the drug.

Arm B: Atezolizumab + Trastuzumab Emtansine

Participants will receive an IV infusion of atezolizumab prior to the IV infusion of trastuzumab emtansine on Day 1 of each 21-day cycle for a total of 14 cycles.

Group Type EXPERIMENTAL

Trastuzumab Emtansine

Intervention Type DRUG

Trastuzumab emtansine will be administered at a dose of 3.6 mg/kg Q3W for 14 weeks.

Trastuzumab

Intervention Type DRUG

Trastuzumab will be used to complete 14 cycles of study treatment if trastuzumab emtansine is discontinued for toxicity not considered to be related to the trastuzumab component of the drug.

Atezolizumab

Intervention Type DRUG

Atezolizumab will be administered at a dose of 1200 mg every three weeks (Q3W) for 14 cycles.

Interventions

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Trastuzumab Emtansine

Trastuzumab emtansine will be administered at a dose of 3.6 mg/kg Q3W for 14 weeks.

Intervention Type DRUG

Placebo

Placebo matched to atezolizumab will be administered at a dose of 1200 mg Q3W for 14 cycles.

Intervention Type DRUG

Trastuzumab

Trastuzumab will be used to complete 14 cycles of study treatment if trastuzumab emtansine is discontinued for toxicity not considered to be related to the trastuzumab component of the drug.

Intervention Type DRUG

Atezolizumab

Atezolizumab will be administered at a dose of 1200 mg every three weeks (Q3W) for 14 cycles.

Intervention Type DRUG

Other Intervention Names

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Tecentriq, RO5541267, MPDL3280A Kadcyla, T-DM1, RO5304020 Herceptin

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed invasive breast carcinoma
* Centrally-confirmed human epidermal growth factor receptor 2 (HER2)-positive invasive breast cancer
* Centrally confirmed PD-L1 and hormone receptor status
* Clinical stage at disease presentation (prior to neoadjuvant therapy): cT4/anyN/M0, any cT/N2-3/M0, or cT1-3/N0-1/M0 (participants with cT1mi/T1a/T1b/N0 are not eligible)
* Completion of pre-operative systemic chemotherapy including at least 9 weeks of taxane and 9 weeks of trastuzumab (anthracycline and/or additional HER2-targeted agents are permitted)
* \<=12 weeks between primary surgery and randomization
* Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
* Screening left ventricular ejection fraction (LVEF) \>= 50% and no decrease in LVEF by \>15% from the pre-chemotherapy LVEF. If no pre-chemotherapy LVEF, screening LVEF \>= 55%
* Life expectancy \>= 6 months
* Adequate hematologic and end organ function

Exclusion Criteria

* Stage IV breast cancer
* An overall response of disease progression according to the investigator at the conclusion of preoperative systemic therapy
* Prior treatment with T-DM1, or atezolizumab, or other immune checkpoint inhibitors
* History of exposure to various cumulative doses of anthracyclines
* History of other malignancy within 5 years prior to screening, except for appropriately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, Stage I uterine cancer, or ductal carcinoma in situ (DCIS)
* Current grade \>=2 peripheral neuropathy
* History of idiopathic pulmonary fibrosis, organizing pneumonia, or pneumonitis
* History of or active autoimmune disease or immune deficiency
* Treatment with immunostimulatory or immunosuppressive agents
* Cardiopulmonary dysfunction
* Any known active liver disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Alabama Oncology

Birmingham, Alabama, United States

Site Status

Roy and Patricia Disney Family Cancer Center- Providence Saint Joseph Medical Center

Buena, California, United States

Site Status

UCLA Medical Center

Santa Monica, California, United States

Site Status

Innovation Clinical Research Institute

Whittier, California, United States

Site Status

Florida Cancer Specialists

West Palm Beach, Florida, United States

Site Status

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital

Carrollton, Georgia, United States

Site Status

University of Iowa

Iowa City, Iowa, United States

Site Status

New England Cancer Specialists

Westbrook, Maine, United States

Site Status

The Valley Hospital

Paramus, New Jersey, United States

Site Status

Levine Cancer Institute

Charlotte, North Carolina, United States

Site Status

Abramson Cancer Center; Univ of Pennsylvania; Clinical Research Unit

Philadelphia, Pennsylvania, United States

Site Status

The West Clinic

Germantown, Tennessee, United States

Site Status

Thompson Cancer Survival Center

Knoxville, Tennessee, United States

Site Status

Mays Cancer Center at UT Health San Antonio MD Anderson Cancer

San Antonio, Texas, United States

Site Status

Hematology Oncology Associates of Fredericksburg, Inc.

Fredericksburg, Virginia, United States

Site Status

Virginia Oncology Associates - New Port News

Newport News, Virginia, United States

Site Status

Virginia Oncology Associates

Norfolk, Virginia, United States

Site Status

Virginia Cancer Institute

Richmond, Virginia, United States

Site Status

Virginia Oncology Associates - Virginia Beach

Virginia Beach, Virginia, United States

Site Status

Providence Regional Cancer Partnership

Everett, Washington, United States

Site Status

Kadlec Clinic Hematology and Oncology

Kennewick, Washington, United States

Site Status

Northwest Medical Specialties

Tacoma, Washington, United States

Site Status

Macarthur Cancer Therapy Centre

Campbelltown, New South Wales, Australia

Site Status

Royal North Shore Hospital

St Leonards, New South Wales, Australia

Site Status

Princess Alexandra Hospital

Woolloongabba, Queensland, Australia

Site Status

Tiroler Landeskrankenanstalten Ges.M.B.H.

Innsbruck, , Austria

Site Status

Ordensklinikum Linz Barmherzige Schwestern

Linz, , Austria

Site Status

Lkh Salzburg - Univ. Klinikum Salzburg

Salzburg, , Austria

Site Status

Cliniques Universitaires St-Luc

Brussels, , Belgium

Site Status

Jessa Zkh (Campus Virga Jesse)

Hasselt, , Belgium

Site Status

Clinique St. Elizabeth

Namur, , Belgium

Site Status

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Ceará, Brazil

Site Status

Hospital Sao Rafael - HSR

Salvador, Estado de Bahia, Brazil

Site Status

Hospital Araujo Jorge

Goiânia, Goiás, Brazil

Site Status

Oncosite - Centro de Pesquisa Clinica Em Oncologia Ltda

Ijuí, Rio Grande do Sul, Brazil

Site Status

Santa Casa de Misericordia de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Hospital Sao Lucas - PUCRS

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Hospital Nossa Senhora da Conceicao

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Hospital de Base de Sao Jose do Rio Preto

São José do Rio Preto, São Paulo, Brazil

Site Status

Clinica de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria Ltda

São Paulo, São Paulo, Brazil

Site Status

Núcleo de Pesquisa São Camilo

São Paulo, São Paulo, Brazil

Site Status

COC Plovdiv

Plovdiv, , Bulgaria

Site Status

Medical Center "Nadezhda Clinical" EOOD

Sofia, , Bulgaria

Site Status

University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD

Sofia, , Bulgaria

Site Status

Sichuan Cancer Hospital

Chengdu, , China

Site Status

West China Hospital - Sichuan University

Chengdu, , China

Site Status

Chongqing Cancer Hospital

Chongqing, , China

Site Status

Sun Yat-sen Memorial Hospital

Guangzhou, , China

Site Status

Guangdong Provincial People's Hospital

Guangzhou, , China

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The First Affilicated Hospital, Sun Yat-sen University

Guangzhou, , China

Site Status

Harbin Medical University Cancer Hospital

Harbin, , China

Site Status

Zhongshan Hospital Fudan University

Shanghai, , China

Site Status

Tianjin Medical University Cancer Institute & Hospital

Tianjin, , China

Site Status

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, , China

Site Status

First Affiliated Hospital of Medical College of Xi'an Jiaotong University

Xi'an, , China

Site Status

Zhejiang Cancer Hospital

Zhejiang, , China

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Henan Cancer Hospital

Zhengzhou, , China

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Masaryk?v onkologický ústav

Brno, , Czechia

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Fakultni Nemocnice Hradec Kralove

Hradec Králové, , Czechia

Site Status

Nemocnice AGEL Novy Jicin a.s.

Nový Jičín, , Czechia

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Fakultni nemocnice Olomouc

Olomouc, , Czechia

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Fakultni Poliklinika Vseobecne Fakultni Niemocnice

Prague, , Czechia

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Fakultni Thomayerova nemocnice

Praha 4 - Krc, , Czechia

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Vejle Sygehus

Vejle, , Denmark

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Institut Sainte Catherine

Avignon, , France

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CHRU Besançon

Besançon, , France

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Polyclinique Bordeaux Nord Aquitaine

Bordeaux, , France

Site Status

CHU Brest Hopital La Cavale Blanche

Brest, , France

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Centre Francois Baclesse

Caen, , France

Site Status

Groupe Hospitalier Public Du Sud De L'Oise GHPSO

Creil, , France

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CLCC Leon Berard Lyon

Lyon, , France

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Centre Hospitalier Uni Ire Caremeau

Nîmes, , France

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Groupe Hospitalier Diaconesses

Paris, , France

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Institut Curie

Paris, , France

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Pole Regional De Cancerologie

Poitiers, , France

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HOPITAL RENE HUGUENIN, Institut Curie

Saint-Cloud, , France

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Klinikum Augsburg

Augsburg, , Germany

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Hochwaldkrankenhaus

Bad Nauheim, , Germany

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Onkologische Schwerpunktpraxis Kurfürstendamm

Berlin, , Germany

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Gynäkologisches Zentrum Bonn

Bonn, , Germany

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Marienhospital Bottrop

Bottrop, , Germany

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Städtisches Klinikum Dessau

Dessau, , Germany

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Gynonco Düsseldorf, MVZ Medical Center GmbH

Düsseldorf, , Germany

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Frauenarztpraxis Dr. Apel, Dr. Kolpin

Erfurt, , Germany

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Klinikum Essen-Mitte Ev. Huyssens-Stiftung / Knappschafts GmbH

Essen, , Germany

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AGAPLESION Markus-Krankenhaus

Frankfurt, , Germany

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Klinik Johann Wolfgang von Goethe Uni

Frankfurt, , Germany

Site Status

Praxis für Interdisziplinäre Onkologie und Hämatologie GbR

Freiburg im Breisgau, , Germany

Site Status

Diakovere Henriettenstift, Frauenklinik

Hanover, , Germany

Site Status

UNI-Klinikum Campus Kiel Klinik für Gynäkologie und Geburtshilfe

Kiel, , Germany

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Städtische Klinik Lüneburg

Lüneburg, , Germany

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Klinik & Poliklinik für Frauenheilkunde und Geburtshilfe, Campus Innenstadt

München, , Germany

Site Status

Klinikum Ernst von Bergmann

Potsdam, , Germany

Site Status

Leopoldina Krankenhaus der Stadt Schweinfurt GmbH

Schweinfurt, , Germany

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Gemeinschaftspraxis für Hämatologie und Onkologie Dr. Reichert/Dr.Janssen

Westerstede, , Germany

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Anticancer Hospital Ag. Savas

Athens, , Greece

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Alexandras General Hospital of Athens

Athens, , Greece

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University General Hospital of Heraklion

Crete, , Greece

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University Hospital of Larissa

Larissa, , Greece

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Metropolitan Hospital

Piraeus, , Greece

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European Interbalkan Medical Center

Thessaloniki, , Greece

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Queen Mary Hospital

Hong Kong, , Hong Kong

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Pamela Youde Nethersole Eastern Hospital

Hong Kong, , Hong Kong

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Tuen Mun Hospital

Hong Kong, , Hong Kong

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Budapesti Szent Margit Korhaz

Budapest, , Hungary

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Orszagos Onkologiai Intezet

Budapest, , Hungary

Site Status

Debreceni Egyetem Klinikai Kozpont

Debrecen, , Hungary

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Hemato Oncology Clinic Ahmedabad Pvt Ltd

Ahmedabad, Gujarat, India

Site Status

Manipal Hospital

Bangalore, Karnataka, India

Site Status

Tata Memorial Hospital

Mumbai, Maharashtra, India

Site Status

HCG Manavata Cancer Centre

Nashik, Maharashtra, India

Site Status

Sahyadri Super Specialty Hospital Hadapsar

Pune, Maharashtra, India

Site Status

Rajiv Gandhi Cancer Institute & Research Center

New Delhi, National Capital Territory of Delhi, India

Site Status

Max Super Speciality Hospital

North WEST Delhi, National Capital Territory of Delhi, India

Site Status

Christian Med Clg & Hspt

Ratnagiri Kilminnal, Tamil Nadu, India

Site Status

TATA Medical Centre

Kolkata, West Bengal, India

Site Status

AORN'S.G.Moscati

Avellino, Campania, Italy

Site Status

U.O.C. Oncologia Medica Senologica

Napoli, Campania, Italy

Site Status

Università degli Studi Federico II

Napoli, Campania, Italy

Site Status

A.O. Universitaria Policlinico Di Modena

Modena, Emilia-Romagna, Italy

Site Status

Irccs Centro Di Riferimento Oncologico (CRO)

Aviano, Friuli Venezia Giulia, Italy

Site Status

Policlinico Universitario Agostino Gemelli

Rome, Lazio, Italy

Site Status

Asst Degli Spedali Civili Di Brescia

Brescia, Lombardy, Italy

Site Status

Ospedale San Raffaele

Milan, Lombardy, Italy

Site Status

Irccs Istituto Nazionale Dei Tumori (Int)

Milan, Lombardy, Italy

Site Status

Ospedale Civile - Livorno

Livorno, Tuscany, Italy

Site Status

Azlenda Ospendaliero-Universitaria Pisana

Pisa, Tuscany, Italy

Site Status

The Aga Khan University-Kenya.

Nairobi, , Kenya

Site Status

Investigacion Oncofarmaceutica

La Paz, Baja California Sur, Mexico

Site Status

Instituto Nacional De Cancerologia

Distrito Federal, Mexico CITY (federal District), Mexico

Site Status

Health Pharma Professional Research

Mexico City, Mexico CITY (federal District), Mexico

Site Status

Centro Medico Dalinde

Mexico City, Mexico CITY (federal District), Mexico

Site Status

Filios Alta Medicina

Monterrey, Nuevo León, Mexico

Site Status

Centro de Investigacion Clinica de Oaxaca

Oaxaca City, Oaxaca, Mexico

Site Status

Auckland City Hospital, Cancer and Blood Research

Auckland, , New Zealand

Site Status

Bialostockie Centrum Onkologii

Bialystok, , Poland

Site Status

Uniwersyteckie Centrum Kliniczne

Gda?sk, , Poland

Site Status

Narodowy Instytut Onkologii Odzia? w Gliwicach

Gliwice, , Poland

Site Status

Szpital Uniwersytecki w Krakowie, Oddzia? Kliniczny Kliniki Onkologii

Krakow, , Poland

Site Status

Wielkopolskie Centrum Onkologii

Poznan, , Poland

Site Status

Centrum Onkologii Instytut im.M. Sklodowskiej-Curie

Warsaw, , Poland

Site Status

Hospital CUF Tejo

Lisbon, , Portugal

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Hospital de Santa Maria

Lisbon, , Portugal

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Hospital Beatriz Angelo

Loures, , Portugal

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IPO do Porto

Porto, , Portugal

Site Status

Filantropia Clinical Hospital

Bucharest, , Romania

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Amethyst Cluj

Cluj County, , Romania

Site Status

Cluj-Napoca Emergency Clinical County Hospital

Cluj-Napoca, , Romania

Site Status

Institutul Oncologic Prof. Dr. Ion Chiricuta Cluj-Napoca

Cluj-Napoca, , Romania

Site Status

Centrul de Oncologie Sfantul Nectarie

Craiova, , Romania

Site Status

Oncomed SRL

Timișoara, , Romania

Site Status

FSBI Russian Oncology Research Center n.a. Blokhin of MOH RF

Moscow, Moscow Oblast, Russia

Site Status

MEDSI Clinical Hospital on Pyatnitsky Highway

Moscow, Moscow Oblast, Russia

Site Status

SBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"

Moskva, Moscow Oblast, Russia

Site Status

Nizhny Novgorod Regional Clinical Oncology Center

Nizhny Novgorod, Niznij Novgorod, Russia

Site Status

Republican Clinical Oncological Dispensary of the Ministry of Healthcare

Kazan, Republic of Karelia, Russia

Site Status

SBI of Healthcare Leningrad Regional Oncology Dispensary

Saint Peterburg, Sankt-Peterburg, Russia

Site Status

Medical Clinic "AB Medical group"

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

FSBI?National Medical Research Center of Oncology named after N.N.Petrov? MHRF

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)

Saint Petersburg, Sankt-Peterburg, Russia

Site Status

SBIH Kaluga Region Clinical Oncology Dispensary

Kaluga, , Russia

Site Status

LLC Medical and Sanitary Unit "Clinician"

Novosibirsk, , Russia

Site Status

Regional Oncology Dispensary

Tomsk, , Russia

Site Status

Regional Clinical Oncology Hospital

Yaroslavl, , Russia

Site Status

National Cancer Centre

Singapore, , Singapore

Site Status

Kyungpook National University Medical Center

Daegu, , South Korea

Site Status

National Cancer Center

Goyang-si, , South Korea

Site Status

Seoul National University Bundang Hospital

Seongnam-si, , South Korea

Site Status

Samsung Medical Center

Seoul, , South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Severance Hospital, Yonsei University Health System

Seoul, , South Korea

Site Status

Asan Medical Center

Seoul, , South Korea

Site Status

Gangnam Severance Hospital

Seoul, , South Korea

Site Status

Seoul St Mary's Hospital

Seoul, , South Korea

Site Status

Korea University Guro Hospital

Seoul, , South Korea

Site Status

Hospital General Universitario de Elche

Elche, Alicante, Spain

Site Status

Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona, Spain

Site Status

Corporacio Sanitaria Parc Tauli

Sabadell, Barcelona, Spain

Site Status

Hospital de Jerez de la Frontera

Jerez de la Frontera, Cadiz, Spain

Site Status

Hospital Alvaro Cunqueiro

Vigo, Pontevedra, Spain

Site Status

Hospital Universitario de Canarias

San Cristóbal de La Laguna, Tenerife, Spain

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Hospital de Basurto

Bilbao, Vizcaya, Spain

Site Status

Hospital Universitario Clínico San Cecilio

Granada, , Spain

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Hospital Juan Ramon Jimenez

Huelva, , Spain

Site Status

Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico

Jaén, , Spain

Site Status

Hospital General Universitario Gregorio Marañon

Madrid, , Spain

Site Status

Hospital Clinico San Carlos

Madrid, , Spain

Site Status

Hospital Quiron de Madrid

Madrid, , Spain

Site Status

Hospital Clinico Universitario Virgen de la Victoria

Málaga, , Spain

Site Status

Hospital Clinico Universitario de Salamanca

Salamanca, , Spain

Site Status

Hospital Universitario Virgen Macarena

Seville, , Spain

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Hospital Universitario Virgen del Rocio

Seville, , Spain

Site Status

Hospital Clínico Universitario de Valencia

Valencia, , Spain

Site Status

Hospital Universitario Miguel Servet

Zaragoza, , Spain

Site Status

Chia-Yi Christian Hospital

Chiayi City, , Taiwan

Site Status

China Medical University Hospital

Taichung, , Taiwan

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National Cheng Kung Uni Hospital

Tainan, , Taiwan

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Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

National Taiwan University Hospital

Taipei, , Taiwan

Site Status

Mackay Memorial Hospital

Taipei, , Taiwan

Site Status

Chulalongkorn Hospital

Bangkok, , Thailand

Site Status

Ramathibodi Hospital

Bangkok, , Thailand

Site Status

Srinagarind Hospital

Khon Kaen, , Thailand

Site Status

Songklanagarind Hospital

Songkhla, , Thailand

Site Status

Adana Baskent University Hospital

Adana, , Turkey (Türkiye)

Site Status

Hacettepe University Medical Faculty

Ankara, , Turkey (Türkiye)

Site Status

Ankara Bilkent City Hospital

Ankara, , Turkey (Türkiye)

Site Status

Gazi University Medical Faculty, Oncology Hospital

Ankara, , Turkey (Türkiye)

Site Status

Memorial Ankara Hastanesi

Ankara, , Turkey (Türkiye)

Site Status

Antalya Training and Research Hospital

Antalya, , Turkey (Türkiye)

Site Status

Ege University Medical Faculty

Bornova, ?zm?r, , Turkey (Türkiye)

Site Status

Dicle University Faculty of Medicine

Diyarbakır, , Turkey (Türkiye)

Site Status

Trakya Universitesi Tip Fakultesi, Medikal Onkoloji Bilim Dali, Balkan Yerleskesi

Edirne, , Turkey (Türkiye)

Site Status

Istanbul Faculty of Medicine

Istanbul, , Turkey (Türkiye)

Site Status

Istanbul University Cerrahpasa Faculty of Medicine

Istanbul, , Turkey (Türkiye)

Site Status

Medeniyet University Goztepe Training and Research Hospital.

Istanbul, , Turkey (Türkiye)

Site Status

Katip Celebi University Ataturk Training and Research Hospital

Izmir, , Turkey (Türkiye)

Site Status

Inonu University Medical Faculty of Medicine

Malatya, , Turkey (Türkiye)

Site Status

Medical Park Seyhan Hospital

Seyhan, , Turkey (Türkiye)

Site Status

Ac?badem Altunizade Hastanesi

Üsküdar, , Turkey (Türkiye)

Site Status

Uganda Cancer Institute

Kampala, , Uganda

Site Status

Uzhgorod Central City Clinical Hospital

Uzhhorod, Katerynoslav Governorate, Ukraine

Site Status

Municipal Noncommercial Institution Regional Center of Oncology

Kharkiv, Kharkiv Governorate, Ukraine

Site Status

Municipal non profit enterprise of Sumy Regional Council Sumy Regional Clinical Oncology Disp

Sumy, Kholm Governorate, Ukraine

Site Status

CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC SI Dnipropetrovsk MA of MOHU Ch of Oncology and MR

Dnipropetrovsk, , Ukraine

Site Status

Municipal Institution Kirovograd Regional Oncology Dispensary

Kirovograd, , Ukraine

Site Status

Kyiv City Clinical Oncological Center

Kyiv, , Ukraine

Site Status

Blackpool Victoria Hospital

Blackpool, , United Kingdom

Site Status

Royal Sussex County Hospital

Brighton, , United Kingdom

Site Status

Addenbrookes Hospital

Cambridge, , United Kingdom

Site Status

Cheltenham General Hospital

Cheltenham, , United Kingdom

Site Status

Barts & London School of Med

London, , United Kingdom

Site Status

University College London Hospital

London, , United Kingdom

Site Status

Royal Free Hospital

London, , United Kingdom

Site Status

Royal Marsden Hospital - London

London, , United Kingdom

Site Status

Christie Hospital NHS Trust

Manchester, , United Kingdom

Site Status

Mount Vernon Cancer Centre

Northwood, , United Kingdom

Site Status

Royal Preston Hospital

Preston, , United Kingdom

Site Status

Royal Cornwall Hospital

Truro, , United Kingdom

Site Status

Countries

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United States Australia Austria Belgium Brazil Bulgaria China Czechia Denmark France Germany Greece Hong Kong Hungary India Italy Kenya Mexico New Zealand Poland Portugal Romania Russia Singapore South Korea Spain Taiwan Thailand Turkey (Türkiye) Uganda Ukraine United Kingdom

References

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Hurvitz SA, Bachelot T, Bianchini G, Harbeck N, Loi S, Park YH, Prat A, Gilham L, Boulet T, Gochitashvili N, Monturus E, Lambertini C, Nyawira B, Knott A, Restuccia E, Schmid P. ASTEFANIA: adjuvant ado-trastuzumab emtansine and atezolizumab for high-risk, HER2-positive breast cancer. Future Oncol. 2022 Oct;18(32):3563-3572. doi: 10.2217/fon-2022-0485. Epub 2022 Nov 16.

Reference Type DERIVED
PMID: 36382554 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2020-003681-40

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

2023-503568-18-00

Identifier Type: CTIS

Identifier Source: secondary_id

WO42633

Identifier Type: -

Identifier Source: org_study_id

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