Trial Outcomes & Findings for Vascular Dysfunction During Physical Inactivity (NCT NCT04872998)

Last Updated: 2026-01-20

Results Overview

The flow rate of brachial artery measured by flow-mediated dilation (FDM). Doppler ultrasound will be used to determine brachial artery vascular function. Specifically, this assessment will include the measurement of flow rate and artery diameter at rest and in response to flow mediated dilation.

Recruitment status

COMPLETED

Study phase

Target enrollment

14 participants

Primary outcome timeframe

Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks)

Results posted on

2026-01-20

Participant Flow

Participant milestones

Participant milestones
Measure	Reduced Activity Reduction of daily step count by 70% for two weeks Step Count Reduction: Subjects reduce daily step counts by approximately 70% through monitoring and recording from step-count monitor
Overall Study STARTED	14
Overall Study COMPLETED	14
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Vascular Dysfunction During Physical Inactivity

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Reduced Activity n=14 Participants Reduction of daily step count by 70% for two weeks Step Count Reduction: Subjects reduce daily step counts by approximately 70% through monitoring and recording from step-count monitor
Age, Continuous	70 years STANDARD_DEVIATION 8 • n=37 Participants
Sex: Female, Male Female	8 Participants n=37 Participants
Sex: Female, Male Male	6 Participants n=37 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=37 Participants
Race (NIH/OMB) Asian	0 Participants n=37 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=37 Participants
Race (NIH/OMB) Black or African American	0 Participants n=37 Participants
Race (NIH/OMB) White	14 Participants n=37 Participants
Race (NIH/OMB) More than one race	0 Participants n=37 Participants
Race (NIH/OMB) Unknown or Not Reported	0 Participants n=37 Participants

PRIMARY outcome

Timeframe: Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks)

Outcome measures

Outcome measures
Measure	Reduced Activity n=14 Participants Reduction of daily step count by 70% for two weeks Step Count Reduction: Subjects reduce daily step counts by approximately 70% through monitoring and recording from step-count monitor
Brachial Artery Vascular Function Baseline FMD	5.1 percent vasodilation Standard Deviation 5.1
Brachial Artery Vascular Function During reduced activity	3.1 percent vasodilation Standard Deviation 2.4
Brachial Artery Vascular Function 2 week post reduced activity	4.4 percent vasodilation Standard Deviation 3.4

SECONDARY outcome

Timeframe: Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks)

Flow rate of popliteal artery measured by flow-mediated dilation (FMD). Doppler ultrasound will be used to determine popliteal artery vascular function. Specifically, this assessment will include the measurement of flow rate and artery diameter at rest and in response to flow mediated dilation.

Outcome measures

Outcome measures
Measure	Reduced Activity n=14 Participants Reduction of daily step count by 70% for two weeks Step Count Reduction: Subjects reduce daily step counts by approximately 70% through monitoring and recording from step-count monitor
Popliteal Artery Vascular Function Baseline FMD	4.5 percent vasodilation Standard Deviation 4.5
Popliteal Artery Vascular Function During reduced activity	2.4 percent vasodilation Standard Deviation 2.1
Popliteal Artery Vascular Function 2 weeks post reduced activity	3.6 percent vasodilation Standard Deviation 2.3

SECONDARY outcome

Timeframe: Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks)

Flow rate of leg microvasculature assessed by passive leg movement (PLM). Doppler ultrasound will be used to determine leg microvasculature function. Specifically, this assessment will include the measurement of flow rate at rest and in response to movement.

Outcome measures

Outcome measures
Measure	Reduced Activity n=14 Participants Reduction of daily step count by 70% for two weeks Step Count Reduction: Subjects reduce daily step counts by approximately 70% through monitoring and recording from step-count monitor
Leg Microvascular Function Baseline FMD	385 ml/min Standard Deviation 313
Leg Microvascular Function During reduced activity	311 ml/min Standard Deviation 202
Leg Microvascular Function 2 weeks post reduced activity	412 ml/min Standard Deviation 290

Adverse Events

Reduced Activity

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Principal Investigator Joel Trinity Associate Professor

University of Utah

Phone: 801-582-1565

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place