Trial Outcomes & Findings for Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial Metastasis (NCT NCT04870645)

NCT ID: NCT04870645

Last Updated: 2024-11-06

Results Overview

Contrast enhancement compared to baseline and normalized to background noise

Recruitment status

COMPLETED

Study phase

Target enrollment

15 participants

Primary outcome timeframe

Participants enrolled in the study were followed for variable amounts of times (up to 2 years and 4 months) from the date of their enrollment and baseline imaging

Results posted on

2024-11-06

Participant Flow

Patients with brain metastases were scanned on a dual-energy CT scanner following iohexol injection at four different time points

Participant milestones

Participant milestones
Measure	Advanced MRI for Intracranial Metastasis Treated With Stereotactic Radiosurgery Single Arm
Overall Study STARTED	15
Overall Study COMPLETED	15
Overall Study NOT COMPLETED	0

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Advanced MRI Scan Before and After Radiation Therapy for the Detection of Intracranial Metastasis

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Advanced MRI for Intracranial Metastasis Treated With Stereotactic Radiosurgery n=15 Participants Single Arm
Age, Categorical <=18 years	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	7 Participants n=5 Participants
Age, Categorical >=65 years	8 Participants n=5 Participants
Sex: Female, Male Female	6 Participants n=5 Participants
Sex: Female, Male Male	9 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	2 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	12 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants
Race (NIH/OMB) Asian	0 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	2 Participants n=5 Participants
Race (NIH/OMB) White	12 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=5 Participants
Region of Enrollment United States	15 Participants n=5 Participants

PRIMARY outcome

Timeframe: Participants enrolled in the study were followed for variable amounts of times (up to 2 years and 4 months) from the date of their enrollment and baseline imaging

Contrast enhancement compared to baseline and normalized to background noise

Outcome measures

Outcome measures
Measure	Advanced MRI for Intracranial Metastasis Treated With Stereotactic Radiosurgery n=15 Participants Single Arm
Contrast to Noise Ratio	3.2 Ratio Standard Deviation 1.1

Adverse Events

Advanced MRI for Intracranial Metastasis Treated With Stereotactic Radiosurgery

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Jason Johnson, MD

M D Anderson Cancer Center

Phone: 713-792-8443

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place