Personalized Circulating DNA Follow-up in Melanoma (PERCIMEL)

NCT ID: NCT04866680

Last Updated: 2025-05-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

165 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-31

Study Completion Date

2029-10-31

Brief Summary

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PERCIMEL is an open multicentric study. The purpose of this study is to assess the interest of molecular analysis on circulating tumor DNA in the follow-up of the disease.

Detailed Description

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Conditions

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Melanoma

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Personalized Circulating DNA follow-up

FFPE tissue sample + blood sample (20ml)

Group Type EXPERIMENTAL

Personalized Circulating DNA follow-up

Intervention Type PROCEDURE

FFPE tissue sample will be collected before and after surgery blood samples will be collected before and after surgery and every 3 to 4 months

Interventions

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Personalized Circulating DNA follow-up

FFPE tissue sample will be collected before and after surgery blood samples will be collected before and after surgery and every 3 to 4 months

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* locally advanced, operable melanoma
* treated by immunotherapy or anti-BRAF and anti-MEK targeted therapies (stage IIIb, IIIc) or exclusive immunotherapy (stage IV) in an adjuvant situation.

Exclusion Criteria

* second cancer
* woman who is pregnant, likely to be pregnant or breastfeeding
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut de Cancérologie de Lorraine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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CHU Jean Minjoz

Besançon, , France

Site Status RECRUITING

CGFL

Dijon, , France

Site Status RECRUITING

Chu Dijon

Dijon, , France

Site Status RECRUITING

Chru Lille

Lille, , France

Site Status RECRUITING

Ghr Mulhouse Sud Alsace

Mulhouse, , France

Site Status RECRUITING

Institut Godinot

Reims, , France

Site Status RECRUITING

Institut de Cancerologie de Lorraine

Vandœuvre-lès-Nancy, , France

Site Status RECRUITING

Chru Nancy

Vandœuvre-lès-Nancy, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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MERLIN JEAN-LOUIS, PharmD, PhD

Role: CONTACT

33 3 83 65 60 62

Facility Contacts

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NARDIN CHARLEE, MD

Role: primary

HERVIEU ALICE, MD

Role: primary

JEUDY GERALDINE, MD

Role: primary

MORTIER LAURENT, MD

Role: primary

MICHEL CATHERINE, MD

Role: primary

Claire CARLIER, Dr

Role: primary

MERLIN JEAN LOUIS, PharmD,PhD

Role: primary

00 33 3 83 65 60 62

GRANEL BROCARD FLORENCE, MD

Role: primary

Other Identifiers

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2022-A01904-39

Identifier Type: -

Identifier Source: org_study_id

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