A Study to Evaluate Safety, Tolerability, PK/PD and Preliminary Efficacy of HBM4003 Combined With Anti-PD-1 Antibody

NCT ID: NCT04866485

Last Updated: 2021-04-29

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 66 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-06-14
• Study Completion Date: 2023-02-28

Brief Summary

This is an open-label, multi-center phase 1 study. The trial, consisting of Part 1a dose confirmation and Part 1b dose expansion, is designed to evaluate the safety, tolerability, PK/PD and preliminary efficacy of HBM4003 in combination with pembrolizumab in patients with advanced NSCLC and other solid tumors.

Detailed Description

subjects will be treated with HBM4003 in combination with pembrolizumab for up to 2 years or until confirmed disease progression, unacceptable tolerability or treatment discontinuation through withdrawal of consent occurs, whichever happens first.

This trial consists of :

• A screening period: 28 days
• A treatment period:

• Part 1a dose confirmation study
• Part 1b dose expansion study
• A post-treatment follow-up period, including

• A safety follow-up period: 28 days after the last dose of study drug;
• Post-treatment follow-up visit: day 84 after the last dose of study drug;
• Survival follow-up.

Conditions

Solid Tumor

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

HBM4003+pembrolizumab

HBM4003 combined with pembrolizumab in subjects with advanced NSCLC and other solid tumors

Group Type: EXPERIMENTAL

HBM4003 and pembrolizumab

Intervention Type: DRUG

Subjects will be treated with HBM4003 and pembrolizumab on Day 1 during each 21-day cycles.

Interventions

HBM4003 and pembrolizumab

Subjects will be treated with HBM4003 and pembrolizumab on Day 1 during each 21-day cycles.

Intervention Type: DRUG

Other Intervention Names

HBM4003

Eligibility Criteria

Inclusion Criteria

• Male or female patients ≥18 years old at the time of signing the informed consent and ≤ 75 years old at the time of enrollment.
• Patients for Part 1a: patients diagnosed with advanced or recurrent solid tumors.
• Patients for Part 1b: patients diagnosed with metastatic NSCLC and confirmed with negative tumor PD-L1 expression (TPS<1%).
• Patients for Part 1b dose expansion study: have never received systemic therapies as primary therapy for advanced or metastatic diseases.
• Patients must be able to provide fresh tumor tissues or archived tumor tissues.
• Patients whose estimated survival time is more than 3 months.
• Patients with at least one measurable lesion at baseline according to RECIST (version 1.1).
• Patients with Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 1.
• Patients whose organ function must meet the study requirements.
• Males or females with childbearing potential need to use an effective contraceptive method.
• Willing and able to comply with study-specified visits schedule, treatment plan, laboratory examination and other study procedures.

Exclusion Criteria

• NSCLC patients with EGFR-sensitive mutations or an ALK translocation based on diagnosis results.
• Patients who are simultaneously participating in another clinical study, unless the study is an observational (non-interventional) clinical study or the patient is already in the survival follow-up period of the interventional study.
• Patients with a medical history of severe allergic diseases, a history of severe drug allergies, and are known or suspected allergy to macromolecular protein preparations or HBM4003 or pembrolizumab excipients.
• Previous and concomitant drugs or treatments to be excluded like CTLA4, PD-1,PD-L1.
• Insufficient completely recovery from previous treatments.
• Diseases that may affect the efficacy and safety of the investigational product.
• A history of other malignant diseases within 5 years before the first dose.
• Active brain metastasis or leptomeningeal metastasis during screening or previous with imaging evidence (based on CT or MRI assessment).
• Patients who have received palliative radiotherapy for non-central nervous system lesions within 2 weeks before the first dose.
• Patients who have received more than 30 Gy of lung radiation therapy within 6 months before the first dose.
• A history of interstitial lung disease or non-infectious pneumonia.
• Patients with pleural effusion, pericardial effusion, or ascites.
• Patients that may have other conditions that affect the efficacy or safety evaluation of this study (such as mental disorder, alcoholism, drug abuse, etc.) .
• Women who are pregnant or breastfeeding, or who plan to become pregnant during the study period and within 3 months after the last dose of study drug.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Harbour BioMed (Guangzhou) Co. Ltd.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Shun LU, Doctor

Role: PRINCIPAL_INVESTIGATOR

Shanghai Chest Hospital

Central Contacts

Xi LIU

Role: CONTACT

hbm4003public@harbourbiomed.com

+8618616529165

Peter ZHAO

Role: CONTACT

hbm4003public@harbourbiomed.com

+8617601647910

Other Identifiers

4003.3

Identifier Type: -

Identifier Source: org_study_id