Developing Dual-channel Transcranial Alternating Current Stimulations Targeting Negative Symptoms in Schizophrenia
NCT ID: NCT04859504
Last Updated: 2024-12-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2021-04-01
2024-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Active tACS
Active tACS will be applied twice daily for 5 days. In each session, dual-channel high-density theta(7Hz) tACS stimulations will be delivered over the right DLPFC (one anodal electrode at F4, between -1.2mA and 1.2 mA; two cathodal electrodes at AF4 and FC6, between -0.6mA and 0.6mA) and cerebellum (one anodal electrode at Oz, between -1 mA and 1mA; two cathodal electrodes at PO3 and PO4, between -0.5mA and 0.5mA) lasting 20 minutes.
transcranial alternating current stimulation (NE Starstim)
dual-channel theta-tACS over right DLPFC and cerebellum simultaneously
Sham tACS
Sham tACS will be also applied twice daily for 5 days.The parameters of tACS electrodes numbers, locations, and current duration are all the same with active tACS. But sham tACS begin with a fade in over 3s to the peak, followed immediately by no current stimulation for 20 minutes and a fade out of 3s.
transcranial alternating current stimulation (NE Starstim)
dual-channel theta-tACS over right DLPFC and cerebellum simultaneously
Interventions
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transcranial alternating current stimulation (NE Starstim)
dual-channel theta-tACS over right DLPFC and cerebellum simultaneously
Eligibility Criteria
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Inclusion Criteria
* present with prominent negative symptoms with PANSS-negative scores \>20, at least one score of PANSS N1-N7 \>3, and reductive ratio of PANSS-negative in the past two weeks before recruitment \<10%;
* stable usage and dosage of anti-psychotic medicines in the past two weeks and during the tACS intervention.
* age within 18-60;
* illness duration \>1year;
* education at least 6 years;
* written consent of receiving tACS intervention.
Exclusion Criteria
* any history of alcohol or substance dependence in the past 3 months;
* any other major physical disease (i.e., Sensorimotor disorder, neurological disease);
* any metal implants or any other tACS contraindication.
18 Years
60 Years
ALL
No
Sponsors
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Shanghai Mental Health Center
OTHER
Responsible Party
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Principal Investigators
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Yingying Tang, PhD
Role: PRINCIPAL_INVESTIGATOR
Shanghai Mental Health Center
Jianhua Sheng, PhD
Role: PRINCIPAL_INVESTIGATOR
Shanghai Mental Health Center
Locations
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Zhengjiang Mental Health Center
Zhenjiang, Jiangsu, China
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China
Countries
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References
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Brady RO Jr, Gonsalvez I, Lee I, Ongur D, Seidman LJ, Schmahmann JD, Eack SM, Keshavan MS, Pascual-Leone A, Halko MA. Cerebellar-Prefrontal Network Connectivity and Negative Symptoms in Schizophrenia. Am J Psychiatry. 2019 Jul 1;176(7):512-520. doi: 10.1176/appi.ajp.2018.18040429. Epub 2019 Jan 30.
Reinhart RMG, Nguyen JA. Working memory revived in older adults by synchronizing rhythmic brain circuits. Nat Neurosci. 2019 May;22(5):820-827. doi: 10.1038/s41593-019-0371-x. Epub 2019 Apr 8.
Smith RC, Md WL, Wang Y, Jiang J, Wang J, Szabo V, Faull R, Jin H, Davis JM, Li C. Effects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophrenia✰. Psychiatry Res. 2020 Feb;284:112617. doi: 10.1016/j.psychres.2019.112617. Epub 2019 Nov 2.
Other Identifiers
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20191836
Identifier Type: -
Identifier Source: org_study_id