Effect of Presenting Survival Information as Text or Pictograph During Periviable Birth Counseling

NCT ID: NCT04859114

Last Updated: 2023-11-24

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1052 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-07

Study Completion Date

2021-06-22

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Women recruited from the internet will be put in a hypothetical situation of being in labor at 22 weeks of pregnancy, and presented with information on the likelihood of survival and chance of disability for babies born at this gestational age.

Participants will be randomized to receive this outcome data in one of three formats: as text-only, in a static pictograph, or in an iterative pictograph. Participants will also be randomized to seeing the chance of survival as 30% or 60%.

Participants were then asked to choose between comfort care and intensive care in this situation. Participants' religiosity, value of the sanctity of life, and health literacy were also assessed.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

A recent study by Kidszun et al. (2020) concluded that for mothers placed in a hypothetical situation of choosing between comfort care and intensive care at 22 weeks gestation, treatment choice was not influenced by the chance of survival. Specifically, there was no difference in treatment choice between moms who were told the baby would have a 30% chance of survival and moms who were told the baby would have a 60% chance of survival.

The study was conducted using a written vignette that included a paragraph on the chance of survival and the chance of disability among the survivors.

In this study, we will adapt the vignette the Kidszun et al. (2020) team used, and provide it to an internet-based sample of women. In this vignette, participants will be put in a hypothetical situation of being in labor at 22 weeks of pregnancy, provided a description of the treatment choices of intensive care or comfort care, and provided data on outcome information at this gestational age.

After reading the vignette, participants will be randomized to view either: a repeat of the text information on outcome data, a static pictograph, or an iterative pictograph. Participants will also be randomized to seeing the chance of survival as 30% or 60%, making this a 2 (chance of survival) x 3 (data presentation format) between-subjects experiment.

After viewing a repeat of the outcome information, participants will be asked to choose between intensive care or comfort care for their hypothetical child. We will also collect information on values, religiosity, health literacy, subjective numeracy, a subjective probability estimate, and demographics.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Premature Birth

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

2x3 between subjects
Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Text-only outcome data, 30% survival

Participants in this arm are provided a repeat of the outcome data in a text-only format, displaying a 30% chance of survival.

Group Type ACTIVE_COMPARATOR

Format of outcome data presentation

Intervention Type BEHAVIORAL

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Displayed chance of survival

Intervention Type BEHAVIORAL

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Text-only outcome data, 60% survival

Participants in this arm view a repeat of the outcome data in a text-only format, displaying a 60% chance of survival.

Group Type ACTIVE_COMPARATOR

Format of outcome data presentation

Intervention Type BEHAVIORAL

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Displayed chance of survival

Intervention Type BEHAVIORAL

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Static pictograph outcome data, 30% survival

Participants in this arm view a static pictograph displaying the outcome data and showing a 30% chance of survival.

Group Type EXPERIMENTAL

Format of outcome data presentation

Intervention Type BEHAVIORAL

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Displayed chance of survival

Intervention Type BEHAVIORAL

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Static pictograph outcome data, 60% survival

Participants in this arm view a static pictograph displaying the outcome data and showing a 60% chance of survival.

Group Type EXPERIMENTAL

Format of outcome data presentation

Intervention Type BEHAVIORAL

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Displayed chance of survival

Intervention Type BEHAVIORAL

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Iterative pictograph outcome data, 30% survival

Participants in this arm view an iterative pictograph displaying the outcome data and showing a 30% chance of survival.

Group Type EXPERIMENTAL

Format of outcome data presentation

Intervention Type BEHAVIORAL

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Displayed chance of survival

Intervention Type BEHAVIORAL

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Iterative pictograph outcome data, 60% survival

Participants in this arm view an iterative pictograph displaying the outcome data and showing a 60% chance of survival.

Group Type EXPERIMENTAL

Format of outcome data presentation

Intervention Type BEHAVIORAL

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Displayed chance of survival

Intervention Type BEHAVIORAL

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Format of outcome data presentation

Outcome data is provided to participants as either text-only, a static pictograph, or an iterative pictograph.

Intervention Type BEHAVIORAL

Displayed chance of survival

In the outcome data provided to participants, they view either a 30% or 60% chance of survival.

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Women who have:

* had a child,
* are currently of child-bearing age (defined as 18-45)
* and who live in the U.S.

Exclusion Criteria

* Minors
* Those unable to read English
* Those who only could complete the survey on their phone. (For formatting purposes, a tablet or computer is necessary.)
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Medical College of Wisconsin

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Mir A Basir

Associate Professor of Pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Medical College of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

McDonnell SM, Basir MA, Yan K, Liegl MN, Windschitl PD. Effect of Presenting Survival Information as Text or Pictograph During Periviable Birth Counseling: A Randomized, Controlled Trial. J Pediatr. 2023 Jun;257:113382. doi: 10.1016/j.jpeds.2023.02.026. Epub 2023 Mar 7.

Reference Type DERIVED
PMID: 36894129 (View on PubMed)

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

2021-121

Identifier Type: -

Identifier Source: org_study_id