Investigation of Cigarette Cravings in Smokers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-20

Study Completion Date

2022-01-31

Brief Summary

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Interventions to disrupt memory reconsolidation have held promise for the treatment of stress- and anxiety-related disorders. In the present study, the investigators will examine whether an intervention based on these principles, called memory updating, could be adapted for reward-seeking behaviors. To test this, non-treatment seeking tobacco smokers will be exposed to smoking cues and/or stress, two stimuli known to trigger smoking. It is predicted that exposure to a stress task will enhance the cues' motivational salience and yield greater susceptibility to the memory updating procedure.

As an add-on, the investigators will examine COVID-associated changes in substance use and whether participants in the memory updating groups might be more resilient to these effects. It is predicted that the changes in substance use will depend on whether the substances are used primarily in social settings.

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Detailed Description

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Non-treatment seeking cigarette dependent smokers will be randomized to one of four testing conditions: 1) a non-stressful task followed by neutral cues, 2) the non-stressful task followed by smoking cues, 3) a stressful task followed by neutral cues, or 4) the stressful task followed by smoking cues. Ten minutes after the intervention, participants will undergo a 60-minute extinction procedure consisting of smoking-related videos, images and smoking paraphernalia. Cue reactivity test sessions will take place 24 hours, 2 weeks and 6 weeks following the intervention.

COVID-associated changes in substance use will be quantified over three telephone interviews: one at the end of March / beginning of April 2020 (at the start of the pandemic), one at the end of April / beginning of May, and a final one which will be instituted if feasible once the infection rates and social distancing policies have decreased.

Conditions

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Cigarette Smoking Addiction Nicotine Tobacco Use

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Stress task and smoking cue

Exposure to a psychosocial stress task followed by smoking video cues

Group Type EXPERIMENTAL

Stress induction

Intervention Type BEHAVIORAL

Exposure to a psychosocial stressor

Cue induction

Intervention Type BEHAVIORAL

Exposure to a smoking-related task

Stress task and neutral cue

Exposure to a psychosocial stress task followed by neutral video cues

Group Type EXPERIMENTAL

Stress induction

Intervention Type BEHAVIORAL

Exposure to a psychosocial stressor

Neutral cue exposure

Intervention Type BEHAVIORAL

Exposure to neutral cues

Control task and smoking cue

Exposure to a control task followed by smoking video cues

Group Type ACTIVE_COMPARATOR

Control stress exposure

Intervention Type BEHAVIORAL

Exposure to a control task (no stress)

Cue induction

Intervention Type BEHAVIORAL

Exposure to a smoking-related task

Control task and neutral cue

Exposure to a control task followed by neutral video cues

Group Type ACTIVE_COMPARATOR

Control stress exposure

Intervention Type BEHAVIORAL

Exposure to a control task (no stress)

Neutral cue exposure

Intervention Type BEHAVIORAL

Exposure to neutral cues

Interventions

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Stress induction

Exposure to a psychosocial stressor

Intervention Type BEHAVIORAL

Control stress exposure

Exposure to a control task (no stress)

Intervention Type BEHAVIORAL

Cue induction

Exposure to a smoking-related task

Intervention Type BEHAVIORAL

Neutral cue exposure

Exposure to neutral cues

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Scoring 5 or higher on the Fagerström Test for Cigarette Dependence
* Willingness to abstain from smoking for 4 hours prior to each laboratory visit