Post Approval Study - Evaluate the Long-Term Safety and Effectiveness of the WEB Device

NCT ID: NCT04839705

Last Updated: 2025-06-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-08-24

Study Completion Date

2029-12-31

Brief Summary

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A prospective, multicenter, single arm, interventional study. The target patient population for this study are adult subjects with WNBAs of the anterior and posterior intracranial circulation. The primary effectiveness outcome of the study is adequate intracranial aneurysm occlusion on the 1 year angiogram as adjudicated by a core laboratory.

Detailed Description

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Conditions

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Wide Neck Bifurcation Intracranial Aneurysms

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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WEB Aneurysm Embolization Device

WEB Aneurysm Embolization Device The WEB is an intra-aneurysmal device intended for use in endovascular embolization of intracranial aneurysms. The intended therapeutic effect of the WEB device is to line the neck of the aneurysm with a metallic structure that disrupts the inflow of blood, causing hemostasis within the aneurysm sac, and leading to thrombus formation within the implant.

Group Type OTHER

WEB

Intervention Type DEVICE

Device: WEB The WEB is an intra-aneurysmal device intended for use in endovascular embolization of intracranial aneurysms.

Other Names:

• WEB Aneurysm Embolization Device

Interventions

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WEB

Device: WEB The WEB is an intra-aneurysmal device intended for use in endovascular embolization of intracranial aneurysms.

Other Names:

• WEB Aneurysm Embolization Device

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient must be ≥ 18 at the time of screening
* Patient must have a single ruptured or unruptured IA requiring treatment
* Patient must sign and date an IRN approved written informed consent prior to initiation of any study procedures

Exclusion Criteria

* Patient has an IA with characteristics unsuitable for endovascular treatment
* Patient has conditions placing them at high risk for ischemic stroke or has exhibited ischemic symptoms such as transient ischemic attacks, minor strokes, or stroke-in-evolution within the prior 30 days
* Patient has had an SAH from a non-index IA or other intracranial hemorrhage within 90 days
* Patient index IA was previously treated
* Patient is pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Microvention-Terumo, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Adam Arthur, MD

Role: PRINCIPAL_INVESTIGATOR

Methodist University Hospital, Memphis TN

David Fiorella, MD

Role: PRINCIPAL_INVESTIGATOR

Stony Brook University, Stony Brook NY

Locations

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Memorial Health Systems

Hollywood, Florida, United States

Site Status RECRUITING

Orlando Health Neuroscience Institute

Orlando, Florida, United States

Site Status RECRUITING

The Queen's Medical Center Neuroscience Institute

Honolulu, Hawaii, United States

Site Status RECRUITING

University of Iowa Hospitals and Clinics

Iowa City, Iowa, United States

Site Status RECRUITING

University of Kansas Health System

Kansas City, Kansas, United States

Site Status RECRUITING

Baptist Health Systems

Lexington, Kentucky, United States

Site Status RECRUITING

University of Kentucky, Department of Neurosurgery

Lexington, Kentucky, United States

Site Status RECRUITING

Norton Healthcare

Louisville, Kentucky, United States

Site Status NOT_YET_RECRUITING

LSU Health Sciences Center at Shreveport

Shreveport, Louisiana, United States

Site Status RECRUITING

University of Maryland, Baltimore

Baltimore, Maryland, United States

Site Status RECRUITING

Johns Hopkins University

Baltimore, Maryland, United States

Site Status RECRUITING

Massachusetts General Brigham Incorporated

Boston, Massachusetts, United States

Site Status NOT_YET_RECRUITING

UMass Memorial Health

Worcester, Massachusetts, United States

Site Status RECRUITING

Abbott Northwestern Hospital Allina Health

Minneapolis, Minnesota, United States

Site Status RECRUITING

The Washington University

St Louis, Missouri, United States

Site Status RECRUITING

Albany Medical Center

Albany, New York, United States

Site Status RECRUITING

University of Buffalo

Buffalo, New York, United States

Site Status RECRUITING

Northshore University Hospital/Northwell Health

Manhasset, New York, United States

Site Status RECRUITING

SUNY Stony Brook

Stony Brook, New York, United States

Site Status RECRUITING

Montefiore Medical Center

The Bronx, New York, United States

Site Status RECRUITING

Duke University

Durham, North Carolina, United States

Site Status RECRUITING

Ohio State University

Columbus, Ohio, United States

Site Status RECRUITING

OhioHealth Research Institute

Columbus, Ohio, United States

Site Status RECRUITING

The Toledo Hospital d/b/a ProMedica Toledo Hospital

Toledo, Ohio, United States

Site Status RECRUITING

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

University of Pennsylvania Health Systems

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Site Status RECRUITING

Semmes Murphey

Memphis, Tennessee, United States

Site Status RECRUITING

West Virginia University

Morgantown, West Virginia, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Amy Bowles

Role: CONTACT

714-482-8074

Facility Contacts

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Piret Baldwin

Role: primary

954-558-1194

Charlene Carlo

Role: primary

407-739-0982

Kelly Diedrich

Role: primary

808-691-4428

Connor Aamot

Role: primary

360-483-9477

Max Hardenbrook

Role: primary

913-588-6191

Candice Brunton

Role: primary

502-708-9791

Rachel Norris

Role: primary

859-218-1644

Trina DeForrest

Role: primary

502-446-8991

Tracy Norwood

Role: primary

318-675-5521

Kaitlyn Henry

Role: primary

410-328-0939

Whitney Isennock

Role: primary

443-262-1657

Austin Birmingham

Role: primary

(845) 500-1694

Noelle Bodkin

Role: primary

508-856-2067

Nimco Essa

Role: primary

614-806-5484

Ramie Heo

Role: primary

314-747-4569

Tuba Ahmed

Role: primary

518-262-5868

Gianna Coscia

Role: primary

716-545-5300

Ali Imran

Role: primary

516-253-7753

Dawn Madigan

Role: primary

631-444-8121

Lavinia Williams

Role: primary

718-502-0552

Amayrani Calvario Salgado

Role: primary

919-681-8585

Megan Frost

Role: primary

567-525-6824

Heather Bartelt

Role: primary

614-788-3863

Diane Philip

Role: primary

419-291-1360

Michael Omini

Role: primary

785-979-6704

Nicole Denney

Role: primary

801-831-1044

Wendell Gaskins

Role: primary

215-503-5646

Wendell Barnett

Role: primary

662-804-9800

Jennifer Domico

Role: primary

304-293-7012

Other Identifiers

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CL11010-001

Identifier Type: -

Identifier Source: org_study_id

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