Pilot Study of 89-Zr Panitumumab in Pancreas Cancer

NCT ID: NCT04833959

Last Updated: 2024-06-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE1

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-26

Study Completion Date

2024-03-31

Brief Summary

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The main purpose of the study is to assess the safety of 89Zr-panitumumab as a molecular imaging agent in patients with (metastatic) pancreas cancer.

Detailed Description

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Conditions

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Pancreas Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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89Zr-Panitumumab

Subjects will be injected with 1 mCi (+/- 20%) of 89Zr-panitumumab followed by PET/CT imaging 4-7 days after study drug injection.

Group Type EXPERIMENTAL

89Zr-panitumumab

Intervention Type DRUG

Imaging Agent

Interventions

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89Zr-panitumumab

Imaging Agent

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of pancreatic cancer.

Exclusion Criteria

* Myocardial infarction (MI); cerebrovascular accident (CVA); uncontrolled congestive heart failure (CHF); significant liver disease; or unstable angina within 6 months prior to enrollment.
* History of infusion reactions to monoclonal antibody therapies.
* Pregnant or breastfeeding.
* Subjects receiving Class IA (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents.
* Subjects with a history or evidence of interstitial pneumonitis or pulmonary fibrosis.
* Severe renal disease or anuria.
* Known hypersensitivity to deferoxamine or any of its components.
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Stanford University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Andrei Iagaru

Role: PRINCIPAL_INVESTIGATOR

Stanford Universiy

Locations

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Stanford University

Stanford, California, United States

Site Status

Countries

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United States

Other Identifiers

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PANC0037

Identifier Type: OTHER

Identifier Source: secondary_id

NCI-2021-03447

Identifier Type: OTHER

Identifier Source: secondary_id

IRB-57641

Identifier Type: -

Identifier Source: org_study_id

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