Study of the of the Safety and Tolerability of TT-00434 in Patients With Advanced Solid Tumors

NCT ID: NCT04830501

Last Updated: 2023-11-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-07-12
• Study Completion Date: 2023-10-18

Brief Summary

This is a phase I study of the safety, tolerability, pharmacokinetics profile, and preliminary efficacy of TT-00434 in patients with advanced solid tumors.

Detailed Description

This is a phase I, First-in-Human (FIH), open-label, dose escalation clinical study in patients who have a histological or cytologically confirmed diagnosis of advanced or recurrent tumors that all standard treatments have been used or are not feasible. It aims to determine the maximum tolerated dose (MTD) and/or the recommended phase 2 dose (RP2D) for study, evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) characteristics and the preliminary anti-tumor activity of TT-00434, and explore the relationship between the anti-tumor activity of TT-00434 and the tumor FGFR alterations.

Conditions

Advanced Solid Tumors

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dose Escalation

This study adopts an accelerated titration design (ATD) and utilizes an accelerated dose escalation phase in order to minimize suboptimal drug exposures, followed by a conventional 3+3 dose escalation phase to achieve MTD.

Group Type: EXPERIMENTAL

TT-00434

Intervention Type: DRUG

Once daily \[QD\], 28 days/cycle.

Interventions

TT-00434

Once daily \[QD\], 28 days/cycle.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age ≥ 20 years.
• Patients must have a histological or cytologically confirmed diagnosis of advanced or recurrent malignant solid tumors.
• Patients have received all currently available standard treatments (unless the therapy is contraindicated, intolerable or unavailable due to any reasons).
• Patients must have measurable or evaluable disease (according to RECIST 1.1)
• Eastern Cooperative Oncology Group (ECOG) Performance Status ≤ 2
• Must agree to take sufficient contraceptive methods to avoid pregnancy during the study and until at least 6 months after ceasing study treatment
• Patients must have fully understood and voluntarily signed informed consent form (ICF) for this study.

Exclusion Criteria

• Patients who received other investigational products or devices in other clinical trials within 4 weeks before the first dose.
• Patients who received anti-tumor therapy within 4 weeks, or within 5-half-lives (which is longer) before the first dose, including but not limited to chemotherapy, radiotherapy (palliative radiotherapy is completed at least 2 weeks before the first dose can enrol), targeted therapy or immunotherapy.
• Patients who have previous toxicity of anti-tumor therapy that has not recovered to Grade 1. (except for ≤ Grade 2 alopecia, chemotherapy-induced peripheral neurotoxicity, and ototoxicity).
• Patients who have gastrointestinal disorders that will affect oral administration or the Investigator judges that the absorption of TT-00434 will be interfered.
• Patients underwent major surgery (except biopsy) within 4 weeks, or the surgical incision has not completely healed prior to the first dose.
• Patients who have active bacterial or fungal infections (CTCAE, Grade ≥ 2) that required systemic treatment within 2 weeks prior to the first dose.
• Patients who have active HBV infection (HBV DNA copies ≥ ULN) and/or HCV infection (HCV RNA copies ≥ ULN)
• Patients who test positive for human immunodeficiency virus (HIV) or known acquired immunodeficiency syndrome.
• Has received a live-virus vaccination within 30 days of planned first dose NOTE: Seasonal flu vaccines are permitted.
• Known or suspected drug hypersensitivity to any ingredients of TT-00434 tablets.
• Female patients in pregnancy or lactation. Male patients or female patients at reproductive ages who are unwilling to receive effective contraceptive measures.
• Patients who are judged by the Investigator to be unsuitable for this study.

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

TransThera Sciences (Nanjing), Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Huey En Tzeng

Role: PRINCIPAL_INVESTIGATOR

Taipei Medical University Hospital

Chia Jui Yen

Role: PRINCIPAL_INVESTIGATOR

National Cheng-Kung University Hospital

Ching Liang Ho

Role: PRINCIPAL_INVESTIGATOR

Tri-Service General Hospital

Ming Che Liu

Role: PRINCIPAL_INVESTIGATOR

Taipei Medical University Hospital

Locations

National Cheng Kung University Hospital

Tainan City, , Taiwan

Taipei Medical University Hospital

Taipei, , Taiwan

Tri-Service General Hospital

Taipei, , Taiwan

Countries

Taiwan

Other Identifiers

TT00434CN01

Identifier Type: -

Identifier Source: org_study_id