A Study to Assess Safety of Nivolumab in Routine Oncology Practice in China

NCT ID: NCT04825873

Last Updated: 2023-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

3102 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-05-28

Study Completion Date

2023-02-13

Brief Summary

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The purpose of this study is to assess the safety of nivolumab in routine cancer practice in China. Part one of the study will investigate nivolumab for non-small cell lung cancer previously treated with platinum-based chemotherapy that has locally advanced or has spread. Part two will investigate nivolumab for post-platinum squamous cell carcinoma of head and neck that is recurrent or has spread. Part three will investigate nivolumab for locally advanced or metastatic non-small cell lung cancer. Part four will investigate nivolumab for recurrent or metastatic squamous cell carcinoma of head and neck.

Detailed Description

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Conditions

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Non-Small Cell Lung Cancer Squamous Cell Carcinoma of Head and Neck

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

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Cohort 1

Prospective observation of participants with non-small cell lung cancer (NSCLC)

No interventions assigned to this group

Cohort 2

Prospective observation of participants with squamous cell carcinoma of head and neck (SCCHN)

No interventions assigned to this group

Cohort 3

Retrospective observation of participants with NSCLC

No interventions assigned to this group

Cohort 4

Retrospective observation of participants with SCCHN

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Part 1

* Histologically or cytologically confirmed diagnosis of locally advanced/metastatic non-small cell lung cancer (NSCLC) participants
* Treatment with nivolumab per physician's prescription

Part 2

* Histologically or cytologically confirmed diagnosis of recurrent/metastatic squamous cell carcinoma of head and neck (SCCHN)
* Treatment with nivolumab for recurrent or metastatic SCCHN

Part 3

* Histologically or cytologically confirmed diagnosis of locally advanced/metastatic NSCLC
* Participants with at least one dose of nivolumab administered since June 2018

Part 4

* Histologically or cytologically confirmed diagnosis of recurrent/metastatic SCCHN
* Participants with at least one dose of nivolumab administered since September 2019

Exclusion Criteria

* Prior participation in a clinical trial within the past 4 weeks
* Current or pending participation in a clinical trial
* Current or pending systemic treatment for cancer other than NSCLC for part 1 and SCCHN for part 2
* Previously treated with immune checkpoint inhibitors for part 3 and part 4
* Participants must not have any other concurrent primary tumor(s) for part 3 and part 4
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Local Institution

Beijing, Beijing Municipality, China

Site Status

Local Institution

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Related Links

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Other Identifiers

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CA209-8JH

Identifier Type: -

Identifier Source: org_study_id

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