Activation of Brown Adipose Tissue Metabolism Using Mirabegron

NCT ID: NCT04823442

Last Updated: 2024-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-21

Study Completion Date

2022-04-04

Brief Summary

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Could sympathomimetics and sympatholytics drugs safe for the management of Type 2 Diabetes (T2D)? Based on recent evidence, we propose that pharmacological stimulation of Beta-3 adrenergic receptor (ADBR3) at higher doses of Mirabegron may be required to elicit changes in glycemia, but should be combined with Beta-1 adrenergic receptor (ADRB1) antagonists to suppress the unwanted effects on the cardiovascular system.

Together, several results establish a previously unappreciated cross-talk between Gs-coupled ADRB1 and ADRB3 in adipose tissue for the control of glucose homeostasis. Moreover, these data suggest that antagonizing ADRB1 may be a good way to significantly lower the dose of ADRB3 agonist required for glucose control.

Therefore, we believe that there are therapeutic opportunities in targeting adrenergic receptors for the treatment of T2D at least in young/middle aged people.

Detailed Description

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In brief, participants will take part in 2 metabolic studies (A and B) performed in random order and at an interval of 7 to 14 days. Each metabolic study will last 8.5 hours with a baseline period of 2.5 hours. Participants will ingest either 200 mg of the ADRB3 agonist mirabegron (Myrbetriq, Astellas Pharma Canada) alone (study A) or in combination with 10 mg of bisoprolol, an ADRB1-antagonist (study B), at time 0.

The radioactive PET tracers (PET: positron emission tomography) used in this study are the \[11C\]-acetate and \[18F\]-FDG to estimate BAT oxidative metabolism and glucose metabolism, respectively. The perfusion of \[6,6 D2\]-glucose, \[1,1,2,3,3-2H\]-glycerol and \[U-13C\]-palmitate stable isotopes will also be performed in this study from time -150 min. to +300 min to examine the systemic appearance rate of glucose, glycerol and fatty acids, respectively. These studies will be almost identical (same perfusion of stable and radioactive tracers, same number of PET acquisitions) except for the drug which will be administered orally at time 0.

Conditions

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Type 2 Diabetes

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Study A

Metabolic PET study with mirabegron

Group Type ACTIVE_COMPARATOR

Mirabegron

Intervention Type DRUG

Mirabegron: a single dose of 200 mg mirabegron (4 tablets of 50 mg)

Study B

Metabolic PET study with mirabegron and bisoprolol

Group Type EXPERIMENTAL

Mirabegron

Intervention Type DRUG

Mirabegron: a single dose of 200 mg mirabegron (4 tablets of 50 mg)

Bisoprolol Fumarate

Intervention Type DRUG

a single dose of 10 mg (2 tablets of 5 mg)

Interventions

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Mirabegron

Mirabegron: a single dose of 200 mg mirabegron (4 tablets of 50 mg)

Intervention Type DRUG

Bisoprolol Fumarate

a single dose of 10 mg (2 tablets of 5 mg)

Intervention Type DRUG

Other Intervention Names

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Myrbetriq Apo Bisoprolol

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects with normal glucose tolerance determined according to an oral glucose tolerance test;
* BMI ≤ 30 kg/m2.

Exclusion Criteria

* Plasma triglycerides \> 5.0 mmol/L at fasting;
* More than 2 alcohol consumption per day;
* More than 1 cigarette per day;
* History of total cholesterol level \> 7 mmol/L, of cardiovascular disease, hypertensive crisis;
* Treatment with fibrates, thiazolidinedione, insulin,betablockers or other drugs with effects on insulin resistance or lipid metabolism (exception for antihypertensive drugs, statins or metformin);
* Presence of a noncontrolled thyroid disease, renal or hepatic disease, history of pancreatitis, bleeding diatheses, cardiovascular disease or any other serious medical conditions;
* History of serious gastrointestinal disorders (malabsorption, peptic ulcer, gastroesophageal reflux having required a surgery, etc.); reflux having required a surgery, etc.);
* Presence of a pacemaker;
* Have undergone of PET study or CT scan in the past year;
* Chronic administration of any medication;
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Laval University

OTHER

Sponsor Role collaborator

Université de Sherbrooke

OTHER

Sponsor Role lead

Responsible Party

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Denis Blondin

Assisant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Denis Blondin

Role: PRINCIPAL_INVESTIGATOR

Université de Sherbrooke

Locations

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Centre de recherche du CHUS

Sherbrooke, Quebec, Canada

Site Status

Countries

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Canada

References

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Dumont L, Caron A, Richard G, Croteau E, Fortin M, Frisch F, Phoenix S, Dubreuil S, Guerin B, Turcotte EE, Carpentier AC, Blondin DP. The effects of the beta1-adrenergic receptor antagonist bisoprolol administration on mirabegron-stimulated human brown adipose tissue thermogenesis. Acta Physiol (Oxf). 2024 May;240(5):e14127. doi: 10.1111/apha.14127. Epub 2024 Mar 19.

Reference Type RESULT
PMID: 38502056 (View on PubMed)

Related Links

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Other Identifiers

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2021-3791

Identifier Type: -

Identifier Source: org_study_id