Consequences of COVID 19 Pandemic on Childhood Asthma

NCT ID: NCT04821908

Last Updated: 2023-12-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

577 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-09-14

Study Completion Date

2025-07-31

Brief Summary

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The SARS-CoV2 pandemic, which emerged in the first quarter of 2020, has led to an unprecedented health crisis in our modern healthcare systems and has resulted in strong national public health measures. The impact of the pandemic and its indirect environmental consequences on pediatric asthma is currently being assessed. In particular, the study of its role on the risk of exacerbations and modification of control is one of the priority research objectives defined by European societies.

The primary aim is to study the impact of the pandemic on asthma control in children aged 3-16 years with a medical diagnosis of asthma, compared to data from other observational cohorts conducted in the same region prior to the pandemic.

A sub-population of children 3-16 years will be assessed at exacerbation and at a follow-up visit, 2-4 months later, with clinical data, biological and microbiological samples.

Detailed Description

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Children aged 3-16 years with a medical diagnosis of asthma, will be assessed for asthma control, exacerbation rate.

Data will be compared to data from other observational cohorts conducted in the same region prior to the pandemic.

A sub-population of children 3-16 years will be assessed at exacerbation and at a follow-up visit, 2-4 months later, with clinical data, biological and microbiological samples.

Conditions

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Asthma in Children

Keywords

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Asthma control COVID-19 pandemic Respiratory infection Environmental pollution

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Group 1

population included in the VIRASTHMA COVID G4 study

No interventions assigned to this group

Group 2

population included in the previous studies "VIRASTHMA", "CHAMPIASTHMA" (IRDCB No.: 2019-A03310-57), "COBRAPED" (NCT02114034), "VIRASTHMA 2" (IRDCB No.: 2014 A01687 40, NCT: 03960359), "INCOVPED" (pediatric emergencies, NCT04336761).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Children and adolescents aged 3 to 16 years old
* With a medical diagnosis of asthma as per-guidelines, who had been followed-up for at least 6 months,
* Assessed in one of the pediatric departments participating in the study,
* After written consent of at least one of the 2 parents and/or representative of the parental authority, and of the child if he is older than 8 years old.

Criteria for the sub-population assessed at "exacerbation" and second visit:

* Children and adolescents aged 3 to 16 years
* With a medical diagnosis of asthma as per-guidelines, who had been followed-up for at least 6 months,
* Hospitalized for a severe asthma exacerbation (requiring hospitalization and general corticosteroid therapy) at Lille University Hospital
* After written consent of both parents and/or representative of the parental authority, and of the child if he is over 8 years old

Exclusion Criteria

* History of chronic respiratory disease other than asthma,
* Inability of parents to receive informed information, inability to participate in the entire study, refusal to sign the consent form
Minimum Eligible Age

3 Years

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Lille

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stéphanie Lejeune, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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CHU Lille

Lille, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Stéphanie Lejeune, MD

Role: CONTACT

Phone: 0320445962

Email: [email protected]

Facility Contacts

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Stephanie Lejeune, MD, PHD

Role: primary

Antoine Deschildre, MD

Role: backup

Other Identifiers

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2020-A03365-34

Identifier Type: OTHER

Identifier Source: secondary_id

2020_85

Identifier Type: -

Identifier Source: org_study_id