Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
30 participants
INTERVENTIONAL
2023-06-01
2030-06-01
Brief Summary
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Detailed Description
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The MR-Linac has been approved by Health Canada for radiation treatment. With superior soft tissue contrast and the possibility for daily plan adaptation, it allows for higher treatment precision delivery, improved target coverage and greater normal tissue sparing.
As a first step, this study will evaluate the feasibility and safety of using the 1.5T MR-Linac on patients with HNC who are treated with SBRT.
Conditions
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Study Design
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NA
SINGLE_GROUP
TREATMENT
NONE
Study Groups
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Head and neck cancer
In this arm patients with head and neck cancers treated with SBRT are recruited.
SBRT on the MR-Linac
Radiotherapy is performed on the 1.5 T MR Linac
Interventions
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SBRT on the MR-Linac
Radiotherapy is performed on the 1.5 T MR Linac
Eligibility Criteria
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Inclusion Criteria
* Karnofsky performance status score of ≥70
* Biopsy-proven oligometastatic cancer to the HN
* Biopsy-proven primary HN cancer (either mucosal, nodal, skin)
* Patients deemed unsuitable by the treating radiation oncologist for radiation treatment with curative intent owing to advanced age, significant comorbidities, poor performance status, distant metastatic disease.
* ≥ 1 site amenable to HN SBRT
* Capable of providing informed consent
* Required to complete any systemic therapy ≥ 10 days prior to planned start of HN SBRT, with no plans to initiate systemic therapy ≥10 days following completion of HN SBRT.
Exclusion Criteria
* Contraindications to MR imaging per institutional policy
* Patients with connective tissue disorders
* History of severe claustrophobia
* Pregnant and or breastfeeding females
* Having an estimated glomerular filtration rate (GFR) \<40 ml/min/1.73m2
18 Years
ALL
Yes
Sponsors
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Sunnybrook Health Sciences Centre
OTHER
Responsible Party
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Dr. Irene Karam
Radiation Oncologist
Principal Investigators
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Irene Karam
Role: PRINCIPAL_INVESTIGATOR
Sunnybrook Health Sciences Centre
Central Contacts
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Other Identifiers
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1509
Identifier Type: -
Identifier Source: org_study_id
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