Trial Outcomes & Findings for Accupressure of P6 to Reduce Nausea During Cesarean Section (NCT NCT04799587)

NCT ID: NCT04799587

Last Updated: 2025-06-06

Results Overview

Presence of intraoperative vomiting during scheduled cesarean delivery (intraoperative period).

• Recruitment status: COMPLETED
• Study phase: NA
• Target enrollment: 200 participants
• Primary outcome timeframe: Intraoperative Period
• Results posted on: 2025-06-06

Participant Flow

200 consented 1 dropped out in the P6 treatment group.

Participant milestones

Measure	Sham Pressure Point The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Overall Study STARTED	100	100
Overall Study COMPLETED	100	99
Overall Study NOT COMPLETED	0	1

Reasons for withdrawal

Measure	Sham Pressure Point The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Overall Study Withdrawal by Subject	0	1

Baseline Characteristics

Accupressure of P6 to Reduce Nausea During Cesarean Section

Baseline characteristics by cohort

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.	Total n=199 Participants Total of all reporting groups
Age, Categorical <=18 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Age, Categorical Between 18 and 65 years	100 Participants n=5 Participants	99 Participants n=7 Participants	199 Participants n=5 Participants
Age, Categorical >=65 years	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Age, Continuous	34.6 Years STANDARD_DEVIATION 4.5 • n=5 Participants	35.3 Years STANDARD_DEVIATION 4.8 • n=7 Participants	35 Years STANDARD_DEVIATION 4.7 • n=5 Participants
Sex: Female, Male Female	100 Participants n=5 Participants	99 Participants n=7 Participants	199 Participants n=5 Participants
Sex: Female, Male Male	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	26 Participants n=5 Participants	20 Participants n=7 Participants	46 Participants n=5 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	74 Participants n=5 Participants	79 Participants n=7 Participants	153 Participants n=5 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) American Indian or Alaska Native	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Asian	8 Participants n=5 Participants	5 Participants n=7 Participants	13 Participants n=5 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Black or African American	10 Participants n=5 Participants	16 Participants n=7 Participants	26 Participants n=5 Participants
Race (NIH/OMB) White	79 Participants n=5 Participants	76 Participants n=7 Participants	155 Participants n=5 Participants
Race (NIH/OMB) More than one race	0 Participants n=5 Participants	0 Participants n=7 Participants	0 Participants n=5 Participants
Race (NIH/OMB) Unknown or Not Reported	3 Participants n=5 Participants	2 Participants n=7 Participants	5 Participants n=5 Participants
Region of Enrollment United States	100 participants n=5 Participants	99 participants n=7 Participants	199 participants n=5 Participants
Height (cm)	163 centimeters STANDARD_DEVIATION 7.5 • n=5 Participants	164 centimeters STANDARD_DEVIATION 7.5 • n=7 Participants	163 centimeters STANDARD_DEVIATION 7.5 • n=5 Participants
Weight (kg)	86 Kilograms STANDARD_DEVIATION 19 • n=5 Participants	89 Kilograms STANDARD_DEVIATION 18 • n=7 Participants	87 Kilograms STANDARD_DEVIATION 18 • n=5 Participants
Body Mass Index (kg/m^2)	31.6 kg/m^2 n=5 Participants	31.4 kg/m^2 n=7 Participants	31.5 kg/m^2 n=5 Participants
American Society of Anesthesiology (ASA) physical status n ASA 2	74 Participants n=5 Participants	81 Participants n=7 Participants	155 Participants n=5 Participants
American Society of Anesthesiology (ASA) physical status n ASA 3	26 Participants n=5 Participants	18 Participants n=7 Participants	44 Participants n=5 Participants
Parity 0	15 Participants n=5 Participants	27 Participants n=7 Participants	42 Participants n=5 Participants
Parity 1	55 Participants n=5 Participants	46 Participants n=7 Participants	101 Participants n=5 Participants
Parity 2	23 Participants n=5 Participants	18 Participants n=7 Participants	41 Participants n=5 Participants
Parity 3	7 Participants n=5 Participants	8 Participants n=7 Participants	15 Participants n=5 Participants
Prior cesarean delivery (n) No prior cesarean delivery	25 Participants n=5 Participants	31 Participants n=7 Participants	56 Participants n=5 Participants
Prior cesarean delivery (n) Yes, previous cesarean delivery	75 Participants n=5 Participants	68 Participants n=7 Participants	143 Participants n=5 Participants
Type of neuraxial anesthesia Spinal	93 Participants n=5 Participants	86 Participants n=7 Participants	179 Participants n=5 Participants
Type of neuraxial anesthesia Combined spinal epidural	7 Participants n=5 Participants	13 Participants n=7 Participants	20 Participants n=5 Participants
Initial BP in operating room (mmHg) Systolic	136 mmHg n=5 Participants	134 mmHg n=7 Participants	135 mmHg n=5 Participants
Initial BP in operating room (mmHg) Diastolic	82 mmHg n=5 Participants	79 mmHg n=7 Participants	80 mmHg n=5 Participants
History of nausea/vomiting No	55 Participants n=5 Participants	50 Participants n=7 Participants	105 Participants n=5 Participants
History of nausea/vomiting Yes	45 Participants n=5 Participants	49 Participants n=7 Participants	94 Participants n=5 Participants

PRIMARY outcome

Timeframe: Intraoperative Period

Presence of intraoperative vomiting during scheduled cesarean delivery (intraoperative period).

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Presence of Intraoperative Vomiting	17 Participants	17 Participants

PRIMARY outcome

Timeframe: Intraoperative period

Presence of intraoperative nausea during scheduled cesarean delivery (intraoperative period).

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Presence of Intraoperative Nausea	57 Participants	56 Participants

SECONDARY outcome

Timeframe: Intraoperative period

Population: Reported number of emesis episodes based on number of subjects who experienced emesis . 17 in sham group and 17 in the P6 acupressure group.

The number of emesis episodes during the cesarean section intraoperative period.

Outcome measures

Measure	Sham Pressure Point n=17 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=17 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Number of Emesis Episodes in the Intraoperative Period Period	2 Emesis episodes Interval 1.0 to 4.0	2 Emesis episodes Interval 1.0 to 4.0

SECONDARY outcome

Timeframe: Intraoperative period

Population: Number of antiemetic and/or anti-nausea medications administered in the intraoperative period.

Reported total number (count) of rescue antiemetics administered per group during the intraoperative period. Rescue antiemetics are defined as the use of intravenous administered prochlorperazine, promethazine, or metoclopramide.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Number of Rescue Antiemetic Doses Administered for the Treatment of Intraoperative Nausea and Vomiting	10 Number of antiemetics per group	10 Number of antiemetics per group

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 hours

Reported total number (count) of emesis episodes per group from admission to the post anesthesia care unit after the operative procedure to discharge from the hospital.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
The Number of Emesis From Post Anesthesia Care Unit to Discharge.	17 Emesis episodes	13 Emesis episodes

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 hours

The number(count) of antiemetic medication administered per group in the post anesthesia care unit through discharge from the hospital

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Antiemetic Medication Administered From the PACU Through Discharge	27 Doses administered	30 Doses administered

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question

Patient recovery questionnaire administered prior to discharge from the hospital. Have you experienced dry retching or vomiting?

Outcome measures

Measure	Sham Pressure Point n=73 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=74 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Have You Experienced Dry Retching or Vomiting Has experienced dry retching	3 Participants	10 Participants
Patient Questionnaire: Have You Experienced Dry Retching or Vomiting Has experienced vomiting	20 Participants	20 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question

Patient recovery questionnaire administered prior to discharge from the hospital. (of those who indicated vomiting) How many times did you vomit.

Outcome measures

Measure	Sham Pressure Point n=73 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=74 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Number of Times Vomited	2 Vomit episodes Interval 1.0 to 4.0	2 Vomit episodes Interval 1.0 to 4.0

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question

Patient recovery questionnaire administered prior to discharge from the hospital. Have you experienced nausea?

Outcome measures

Measure	Sham Pressure Point n=73 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=74 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Number of Participants With Nausea	51 Participants	53 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question. 51 in the sham group and 53 in the P6 group reported nausea.

Patient recovery questionnaire administered prior to discharge from the hospital. (of those who had nausea)Describe the pattern of your nausea (2 choices).

Outcome measures

Measure	Sham Pressure Point n=51 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=53 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Describe the Pattern of Your Nausea? Nausea comes and goes	40 Participants	44 Participants
Patient Questionnaire: Describe the Pattern of Your Nausea? Nausea is constant	5 Participants	2 Participants
Patient Questionnaire: Describe the Pattern of Your Nausea? No response	6 Participants	7 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question. 51 in the sham group and 53 in the P6 group reported nausea.

Patient recovery questionnaire administered prior to discharge from the hospital. (of those who had nausea) How did the nausea interfere with your ability to care for yourself.

Outcome measures

Measure	Sham Pressure Point n=51 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=53 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Did the Nausea Interfere With You Ability to Care for Yourself? No interference	36 Participants	34 Participants
Patient Questionnaire: Did the Nausea Interfere With You Ability to Care for Yourself? A little interference	11 Participants	11 Participants
Patient Questionnaire: Did the Nausea Interfere With You Ability to Care for Yourself? Some of the time	1 Participants	2 Participants
Patient Questionnaire: Did the Nausea Interfere With You Ability to Care for Yourself? Most of the time	3 Participants	4 Participants
Patient Questionnaire: Did the Nausea Interfere With You Ability to Care for Yourself? No response	0 Participants	2 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question. 51 in the sham group and 53 in the P6 group reported nausea.

Patient recovery questionnaire administered prior to discharge from the hospital. (of those who had nausea) How many hours did the nausea last.

Outcome measures

Measure	Sham Pressure Point n=51 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=53 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Duration of Nausea.	2 Hours Interval 0.5 to 14.0	4 Hours Interval 2.0 to 8.0

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 73 in the sham group and 74 in the P6 group completed the survey question. 51 in the sham group and 53 in the P6 group reported nausea.

Patient recovery questionnaire administered prior to discharge from the hospital. (of those who had nausea).Severity of nausea based on a 0 (none) -100 (very severe).

Outcome measures

Measure	Sham Pressure Point n=51 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=53 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Severity of Nausea. Highest level of nausea	50 score on a scale (0 good-100 severe) Interval 18.0 to 70.0	63 score on a scale (0 good-100 severe) Interval 29.0 to 78.0
Patient Questionnaire: Severity of Nausea. Lowest level of nausea	4 score on a scale (0 good-100 severe) Interval 0.0 to 17.0	4 score on a scale (0 good-100 severe) Interval 0.0 to 23.0

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: Please note 62 in the sham group and 64 in the P6 group completed this survey question.

Patient recovery questionnaire administered prior to discharge from the hospital. Does the magnet improve nausea response yes or no.

Outcome measures

Measure	Sham Pressure Point n=62 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=64 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Do You Think the Magnet Improves Nausea? Improves nausea (yes)	23 Participants	25 Participants
Patient Questionnaire: Do You Think the Magnet Improves Nausea? Does not improve nausea (no)	39 Participants	39 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: Please not that 60 in the sham group and 62 in the P6 group completed the survey question.

Patient recovery questionnaire administered prior to discharge from the hospital. Does the magnet improve vomiting response yes or no.

Outcome measures

Measure	Sham Pressure Point n=60 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=62 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Do You Think the Magnet Improves Vomiting? Improves vomiting (yes)	15 Participants	19 Participants
Patient Questionnaire: Do You Think the Magnet Improves Vomiting? Does not improve vomiting (no)	45 Participants	43 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: 96 Hours

Population: 61 in the sham group and 65 in the P6 group completed the survey question.

Patient recovery questionnaire administered prior to discharge from the hospital. Are you satisfied with acupressure response yes or no.

Outcome measures

Measure	Sham Pressure Point n=61 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=65 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Patient Questionnaire: Are You Satisfied With Acupressure? Satisfied with acupressure (yes)	29 Participants	33 Participants
Patient Questionnaire: Are You Satisfied With Acupressure? Not satisfied with acupressure (no)	32 Participants	32 Participants

OTHER_PRE_SPECIFIED outcome

Timeframe: Intraoperative period

Lowest systolic and diastolic blood pressure during the intraoperative period.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Intraoperative Lowest BP (mmHg) Systolic Blood Pressure	116 mm/Hg Interval 106.0 to 124.0	111 mm/Hg Interval 105.0 to 121.0
Intraoperative Lowest BP (mmHg) Diastolic Blood Pressure	61 mm/Hg Interval 56.0 to 69.0	60 mm/Hg Interval 56.0 to 69.0

OTHER_PRE_SPECIFIED outcome

Timeframe: Intraoperative period

Measure Description: Total vasopressor units expressed as phenylephrine units using an 80:1 ratio for ephedrine in micrograms.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Intraoperative Total Vasopressor (VPE) [1]	2052 micrograms Interval 1288.0 to 2918.0	2190 micrograms Interval 1550.0 to 2950.0

OTHER_PRE_SPECIFIED outcome

Timeframe: Intraoperative

Number of hypotension episodes experienced during the intraoperative period.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Intraoperative Hypotension Episodes (n)	1 Hypotension episodes Interval 0.0 to 2.0	1 Hypotension episodes Interval 0.0 to 2.0

OTHER_PRE_SPECIFIED outcome

Timeframe: Intraoperative period

Amount of crystalloid fluids given as a co-load in milliliters during the intraoperative period.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Intraoperative Crystalloid Co-load (mL)	500 Milliliters Interval 300.0 to 600.0	500 Milliliters Interval 300.0 to 600.0

OTHER_PRE_SPECIFIED outcome

Timeframe: Intraoperative

Total number of milliliters of fluids administered during the intraoperative period.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Intraoperative Fluids Administered (mL)	2000 Milliliters Interval 1600.0 to 2175.0	1800 Milliliters Interval 1500.0 to 2100.0

OTHER_PRE_SPECIFIED outcome

Timeframe: Intraoperative period

Duration of administration of intraoperative anesthesia in minutes.

Outcome measures

Measure	Sham Pressure Point n=100 Participants The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 Participants The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Duration of Intraoperative Anesthesia (Min)	81 Minutes Interval 70.0 to 98.0	81 Minutes Interval 73.0 to 103.0

Adverse Events

Sham Pressure Point

Serious events: 0 serious events

Other events: 57 other events

Deaths: 0 deaths

P6 Accupressure Group

Serious events: 0 serious events

Other events: 56 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Measure	Sham Pressure Point n=100 participants at risk The sham pressure point (distal to the P6 acupressure point). Magnet applied to arm not at P6 pressure point.: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.	P6 Accupressure Group n=99 participants at risk The pressure point will be stimulated by the presence of the magnet when positioned properly on the P6 acupressure point. Additional pressure may be applied as desired by the study subject but is not necessary for P6 stimulation. Magnet at P6: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.
Gastrointestinal disorders Nausea	57.0% 57/100 • Number of events 57 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.	56.6% 56/99 • Number of events 56 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.
Gastrointestinal disorders Emesis during operative period	17.0% 17/100 • Number of events 43 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.	17.2% 17/99 • Number of events 33 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.
Gastrointestinal disorders Emesis in post anesthesia care unit	4.0% 4/100 • Number of events 4 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.	9.1% 9/99 • Number of events 9 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.
Gastrointestinal disorders Emesis (floor)	17.0% 17/100 • Number of events 17 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.	13.1% 13/99 • Number of events 13 • 72 Hours Adverse events were collected on a survey provided to the participant up to 72 hours after delivery.

Additional Information

Paul Fitzgerald, RN, BSN,MS

Northwestern University

Phone: 312-695-1064

Email: p-fitzgerald2@northwestern.edu

Results disclosure agreements

• Principal investigator is a sponsor employee
• Publication restrictions are in place