Assessing Clinical Outcomes in Alzheimer's Disease Agitation

NCT ID: NCT04797715

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

178 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-31

Study Completion Date

2022-11-21

Brief Summary

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This is a multi-center, double-blind, placebo-controlled, randomized withdrawal study to evaluate the efficacy and safety of AXS-05 compared to placebo in the treatment of agitation symptoms in subjects with agitation associated with Alzheimer's disease.

Detailed Description

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Enrolled patients will first enter a 9-week, open-label stabilization period, during which they will be treated with AXS-05 and monitored for a treatment response. Patients who experience a treatment response during the stabilization period will then be randomized into the double-blind treatment period, in a 1:1 ratio, to continue treatment with AXS-05 or to switch to placebo, for up to 26 weeks or until a relapse of agitation occurs.

Conditions

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Agitation in Patients With Dementia of the Alzheimer's Type Alzheimer Disease Agitation,Psychomotor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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AXS-05

Up to 26 weeks in double-blind period

Group Type EXPERIMENTAL

AXS-05

Intervention Type DRUG

AXS-05 tablets, taken twice daily

Placebo

Up to 26 weeks in double-blind period

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo tablets, taken twice daily

Interventions

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AXS-05

AXS-05 tablets, taken twice daily

Intervention Type DRUG

Placebo

Placebo tablets, taken twice daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of probable Alzheimer's disease (AD) based on the 2011 National Institute on Aging-Alzheimer Association (NIA-AA) criteria.
* Diagnosis of clinically signification agitation resulting from probable AD according to the International Psychogeriatric Association (IPA) provisional definition of agitation.

Exclusion Criteria

* Patient has dementia predominantly of non-Alzheimer's type.
* Patient has symptoms of agitation that are not secondary to AD (e.g., pain, other psychiatric disorder or delirium due to a metabolic disorder, systemic infection, or substance-induced).
* Unable to comply with study procedures.
* Medically inappropriate for study participation in the opinion of the investigator.
Minimum Eligible Age

65 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Axsome Therapeutics, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Clinical Research Site

Sun City, Arizona, United States

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Tucson, Arizona, United States

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Chula Vista, California, United States

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Imperial, California, United States

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Lafayette, California, United States

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Los Alamitos, California, United States

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Los Angeles, California, United States

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Oceanside, California, United States

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San Diego, California, United States

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Santa Ana, California, United States

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Temecula, California, United States

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Coral Springs, Florida, United States

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Hialeah, Florida, United States

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Kissimmee, Florida, United States

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Lake City, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami, Florida, United States

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Miami Lakes, Florida, United States

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Naples, Florida, United States

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Ocoee, Florida, United States

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Orlando, Florida, United States

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Orlando, Florida, United States

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Pembroke Pines, Florida, United States

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Pensacola, Florida, United States

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St. Petersburg, Florida, United States

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Sunrise, Florida, United States

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Tampa, Florida, United States

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Trinity, Florida, United States

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Augusta, Georgia, United States

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Columbus, Georgia, United States

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Suwanee, Georgia, United States

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Honolulu, Hawaii, United States

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Boise, Idaho, United States

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Wichita, Kansas, United States

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Bangor, Maine, United States

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Lowell, Massachusetts, United States

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Flint, Michigan, United States

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Chesterfield, Missouri, United States

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Las Vegas, Nevada, United States

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Toms River, New Jersey, United States

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Brooklyn, New York, United States

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East Syracuse, New York, United States

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New Windsor, New York, United States

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New York, New York, United States

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Charlotte, North Carolina, United States

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Hickory, North Carolina, United States

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Dayton, Ohio, United States

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Jenkintown, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Austin, Texas, United States

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Cypress, Texas, United States

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Houston, Texas, United States

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McKinney, Texas, United States

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Mesquite, Texas, United States

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San Antonio, Texas, United States

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Sugar Land, Texas, United States

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West Jordan, Utah, United States

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Woodstock, Vermont, United States

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Everett, Washington, United States

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Waukesha, Wisconsin, United States

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Kelowna, British Columbia, Canada

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Newmarket, Ontario, Canada

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Countries

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United States Canada

Related Links

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http://axsome.com/

Axsome Therapeutics Website

Other Identifiers

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AXS-05-AD-302

Identifier Type: -

Identifier Source: org_study_id