LLLT and Russian Electrical Stimulation in Osteoarthritis

NCT ID: NCT04788706

Last Updated: 2021-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-01

Study Completion Date

2020-12-01

Brief Summary

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Objectives: To investigate the effect of low-level laser therapy (LLLT) application combined with Russian Electrical Stimulation on pain, mobility, functionality, range of motion, muscular strength, and activity in patients with osteoarthritis of the knee.

Design: Randomized controlled double-blind study. Setting: Specialist Rehabilitation Services.

Detailed Description

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ABSTRACT Objectives: To investigate the effect of low-level laser therapy (LLLT) application combined with Russian Electrical Stimulation on pain, mobility, functionality, range of motion, muscular strength, and activity in patients with osteoarthritis of the knee.

Design: Randomized controlled double-blind study. Setting: Specialist Rehabilitation Services. Participants: Eighty participants with knee osteoarthritis were randomized. Intervention: Participants were randomized into four groups: Group I (n=20; LLLT over three weeks followed by an eight-week receiving Russian electrical stimulation), Group II (n=20; Placebo laser over three weeks followed by an eight-week receiving Russian electrical stimulation), Group III (n=20; LLLT over three weeks followed by an eight-week receiving LLLT application combined with Russian electrical stimulation), Group IV (n=20; Placebo laser over three weeks followed by an eight-week receiving Placebo laser application combined with Russian electrical stimulation). The groups treated with LLLT received treatments with invisible infrared laser (904 nm, 3 Joules/point). The Placebo groups received identical treatment, but the infrared laser output was disabled. The sessions occurred three times a week.

Main outcome measures: The primary outcome was the change in knee pain and functionality (Lequesne). Secondary outcomes included change in mobility (8 meters and Timed Up and Go test), range of motion (goniometer), muscular strength (dynamometer), activity (Western Ontario and McMaster Universities Osteoarthritis questionnaire) and medication intake.

Conditions

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Osteo Arthritis Knee

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Group I

LLLT over three weeks followed by an eight-week receiving Russian electrical stimulation

Group Type ACTIVE_COMPARATOR

Low level Laser Therapy and Russian electrical stimulation

Intervention Type OTHER

LLLT over three weeks followed by an eight-week receiving Russian electrical stimulation

Group II

Placebo laser over three weeks followed by an eight-week receiving Russian electrical stimulation

Group Type PLACEBO_COMPARATOR

Placebo Laser and Russian electrical stimulation

Intervention Type OTHER

Placebo laser over three weeks followed by an eight-week receiving Russian electrical stimulation

Group III

LLLT over three weeks followed by an eight-week receiving LLLT application combined with Russian electrical stimulation

Group Type ACTIVE_COMPARATOR

Low level Laser Therapy and Low level Laser Therapy plus Russian electrical stimulation

Intervention Type OTHER

LLLT over three weeks followed by an eight-week receiving LLLT application combined with Russian electrical stimulation

Group IV

Placebo laser over three weeks followed by an eight-week receiving Placebo laser application combined with Russian electrical stimulation

Group Type PLACEBO_COMPARATOR

Placebo Laser and Placebo Laser plus Russian electrical stimulation

Intervention Type OTHER

Placebo laser over three weeks followed by an eight-week receiving Placebo laser application combined with Russian electrical stimulation

Interventions

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Low level Laser Therapy and Russian electrical stimulation

LLLT over three weeks followed by an eight-week receiving Russian electrical stimulation

Intervention Type OTHER

Placebo Laser and Russian electrical stimulation

Placebo laser over three weeks followed by an eight-week receiving Russian electrical stimulation

Intervention Type OTHER

Low level Laser Therapy and Low level Laser Therapy plus Russian electrical stimulation

LLLT over three weeks followed by an eight-week receiving LLLT application combined with Russian electrical stimulation

Intervention Type OTHER

Placebo Laser and Placebo Laser plus Russian electrical stimulation

Placebo laser over three weeks followed by an eight-week receiving Placebo laser application combined with Russian electrical stimulation

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. levels 2-4 according to Kellgren-Lawrence grade
2. aged 50-75 years
3. both genders
4. have knee pain and functional disability for at least three months
5. according to the criteria of the American College for Rheumatology.

Exclusion Criteria

* cancer, diabetes, symptomatic hip osteoarthritis, or used antidepressants, anti-inflammatory medications or anxiolytics during six months prior to enrolment.
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Sao Paulo General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Patricia P Alfredo, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

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Department of Physical Therapy, Speech and Occupational Therapy of University of São Paulo

São Paulo, , Brazil

Site Status

Countries

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Brazil

Other Identifiers

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0775/08

Identifier Type: -

Identifier Source: org_study_id

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