Rectrospect - a Retrospective Study of Treatment Response

NCT ID: NCT04787523

Last Updated: 2023-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

170 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-01

Study Completion Date

2022-12-31

Brief Summary

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Biopisies from patients diagnosed with rectal cancer between 2007-2019 will be cut into 4-6 micrometer thin sections for morphology and immunostaining. Every section will be numbered with a code that is connected to the patients personal identification number and the code list will be kept separately from the biopsies in a password protected file on the Sahlgrenska University Hospital server.

Patient data and outcome regarding response to treatment will be collected from patient charts and the Swedish ColoRectal Cancer Registry, but all data will be numbered with the same code number and all results will be kept away from the code list. In order to achieve the stated aims, that is, to study how the molecular and cellular characteristics of the tumour and its surrounding microenvironment as well as the interaction of tumour cells and immune cells affect treatment response, several molecular and cellular techniques and assays may be applied.

Detailed Description

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Conditions

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Rectal Neoplasms

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Patients with pathological response to treatment

Response evaluated using the pathology report

Radiotherapy

Intervention Type RADIATION

Patients have received neoadjuvant radiotherapy

Interventions

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Radiotherapy

Patients have received neoadjuvant radiotherapy

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Rectal cancer and treatment between 2007 and 2019

Exclusion Criteria

* No rectal cancer or no neoadjuvant treatment
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Eva Angenete

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Dept. of Surgery, Sahlgrenska University Hospital/Ostra

Gothenburg, , Sweden

Site Status

Countries

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Sweden

Other Identifiers

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Rectrospect

Identifier Type: -

Identifier Source: org_study_id

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