A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of JS004 in Advanced Solid Tumors

NCT ID: NCT04773951

Last Updated: 2021-08-24

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 156 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-04-12
• Study Completion Date: 2024-08-31

Brief Summary

An open-label, dose-escalation, phase I clinical study to evaluate the safety and tolerability of JS004 injection in the patients with advanced solid tumors who have failure in standard of care and are unable to tolerate standard of care and/or have no available standard of care. The study is divided into screening period, treatment period, and follow-up period.

1. Screening period: Subjects will be included in the screening period after signing the informed consent form (ICF). The screening period is up to 28 days, subjects will enter the study treatment period if they meet all the inclusion criteria and none of exclusion criterion.

2. Treatment period: Subjects will be allocated to the designated dose group to receive corresponding treatment in accordance with the progress of study. Subjects in dose escalation phase will receive DLT observation at first, and upon completion of DLT observation, the subjects will continue their administration at the original dose if they are tolerated as judged by investigator, until progression of disease, intolerable toxicity or other reasons specified in the protocol. Subjects in the dose extension phase receive appropriate study treatment until disease progression, intolerance of toxicity, or other causes specified in the protocol occur. Response evaluation criteria in solid tumors (RECIST v1.1) will be used for efficacy evaluation every 9 weeks (±7 days) in the first year and every 12 weeks (±7 days) in the 2nd year and thereafter.

3. Follow-up period: A safety follow-up visit is required 30 days (±7 days) after the last dose of study drug or before the initiation of new antitumor therapy. If the new antitumor therapy has not been initiated, additional safety follow-up should be completed 90 days (±7 days) after the last dose as far as possible.

Conditions

Melanoma; Renal Carcinoma; Urothelial Carcinoma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Dose escalation and extension group

1. JS004 dose escalation: 1mg/kg, IV Q3W; 3mg/kg, IV Q3W; 10mg/kg, IV Q3W;

2. JS004 dose extension: 3mg/kg, IV Q3W; 200mg, IV Q3W;

3. JS004+Toripalimab Injection dose escalation: JS004 100mg+Toripalimab Injection 240mg, IV Q3W; JS004 200mg+Toripalimab Injection 240mg, IV Q3W;

4. JS004+Toripalimab Injection dose extension: JS004 100mg+Toripalimab Injection 240mg, IV Q3W or JS004 200mg+Toripalimab Injection 240mg, IV Q3W，to be determined.

Group Type: EXPERIMENTAL

JS004, a recombinant humanized, IgG4κ monoclonal antibody (mAb) specific to B- and T-lymphocyte attenuator (BTLA); Toripalimab Injection

Intervention Type: BIOLOGICAL

Biological: JS004, Intravenous infusion; Toripalimab Injection, Intravenous infusion

Interventions

JS004, a recombinant humanized, IgG4κ monoclonal antibody (mAb) specific to B- and T-lymphocyte attenuator (BTLA); Toripalimab Injection

Biological: JS004, Intravenous infusion; Toripalimab Injection, Intravenous infusion

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

Only the patients meeting the following criteria are eligible to participate in the study:

1. Voluntarily signed written informed consent form;

2. Age ≥18 and ≤70 years at the time of signing informed consent form, male or female;

3. Life expectancy ≥ 3 months;

4. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0 or 1;

5. Patients with histologically or cytologically confirmed advanced solid tumors: patients with advanced solid tumors who have failure in standard of care, cannot tolerate standard of care, refuse and/or have no standard of care (melanoma, renal carcinoma and urothelial carcinoma);

6. At least one measurable lesion as target lesion (RECIST v1.1);

7. Agree to provide tumor tissue specimen ( fresh biopsied sample before treatment should be provided as far as possible, the archived sample within two years is acceptable for the patients who cannot provide fresh biopsied sample before treatment);

8. Adequate organ function as indicated by the laboratory results during the screening period;

9. Use of effective contraceptive methods during the study for male subjects of reproduction ability or female subjects of childbearing potential, and continuation of contraception for 6 months after the end of treatment;

10. Good compliance, cooperation with follow-up.

Exclusion Criteria

Patients will be excluded from the study when they have any of the following conditions:

1. History of malignant tumors other than the disease investigated in the past 5 years, however, except for the malignant tumors that can be expected to be cured after treatment;

2. Having received systematic antitumor therapy, or local antitumor therapy, or treatment with clinically investigational medication or device within 4 weeks prior to the first dose of study drug;

3. Having received immunotherapy within 4 weeks prior to first dose of study drug;

4. Previously treated with anti-BTLA or anti-HVEM antibody;

5. Adverse reaction induced by previous therapy having not recovered to CTCAE (version 5.0) grade 1 or better;

6. Having previously received allogeneic hematopoietic stem cell transplantation or solid organ transplantation;

7. Having central nervous system metastases and/or cancerous meningitis;

8. Having or suspected to have active autoimmune disease;

9. Having hepatitis and liver cirrhosis;

10. Massive hydrothorax or ascites with clinical symptoms or requiring symptomatic treatment;

11. Having severe cerebro- and cardiovascular diseases;

12. Having pulmonary disease;

13. Having active infection requiring systemic treatment;

14. Positive result for human immunodeficiency virus (HIV) antibody;

15. Active hepatitis B or C;

16. Known active tuberculosis (TB);

17. Use of systemic corticosteroids 14 days prior to the first dose of study drug;

18. Use of broad-spectrum antibiotics that may affect the change of intestinal flora within 14 days prior to the first dose of study drug;

19. Vaccination of live vaccine within 4 weeks prior to the first dose of study drug;

20. Having received major surgery within 4 weeks prior to the first dose of study drug;

21. History of anti-psychotics abuse and unable to abstain, or with a history of mental disorder;

22. Pregnant or breast-feeding women;

23. Known allergy to JS004 and its components;

24. Other severe, acute or chronic medical conditions or mental diseases or laboratory abnormalities possibly increasing relevant risks in participation in the study or possibly interfering with the interpretation of study results as judged by investigators.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Shanghai Junshi Bioscience Co., Ltd.

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Jun Guo

Role: PRINCIPAL_INVESTIGATOR

Peking University Cancer Hospital & Institute

Locations

Fujian Provincial Cancer Hospital

Fuzhou, Fujian, China

Site Status: NOT_YET_RECRUITING

Tumor Hospital affiliated to Harbin Medical University

Harbin, Heilongjiang, China

Site Status: NOT_YET_RECRUITING

Hunan Cancer Hospital

Changsha, Hunan, China

Site Status: NOT_YET_RECRUITING

Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China

Site Status: NOT_YET_RECRUITING

First Hospital of Jilin University

Changchun, Jilin, China

Site Status: NOT_YET_RECRUITING

West China Hospital of Sichuan University

Chengdu, Sichuan, China

Site Status: NOT_YET_RECRUITING

Run Run Shaw Hospital affiliated to Zhejiang University Medical College

Hangzhou, Zhejiang, China

Site Status: NOT_YET_RECRUITING

Zhejiang Cancer Hospital

Hangzhou, Zhejiang, China

Site Status: NOT_YET_RECRUITING

Beijing Cancer Hospital

Beijing, , China

Site Status: RECRUITING

Fudan University Shanghai Cancer Center

Shanghai, , China

Site Status: NOT_YET_RECRUITING

Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology

Wuhan, , China

Site Status: NOT_YET_RECRUITING

Countries

China

Central Contacts

Liang Gao

Role: CONTACT

liang_gao@junshipharma.com

13263288215

Ling Xiao

Role: CONTACT

ling_xiao@junshipharma.com

13408654655

Facility Contacts

Yu Chen

Role: primary

Jin Wu

Role: primary

Lin Wu

Role: primary

Zhengyun Zou

Role: primary

Di Wu

Role: primary

Jiyan Liu

Role: primary

Hongming Pan

Role: primary

Yumei Fang

Role: primary

Jun Guo

Role: primary

Zhiguo Luo

Role: primary

Jing Chen

Role: primary

Other Identifiers

HMO-JS004-I-CT01

Identifier Type: -

Identifier Source: org_study_id