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Assessment of Executive Functions After Covid-19

NCT ID: NCT04771624

Last Updated: 2021-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

128 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-30

Study Completion Date

2021-11-01

Brief Summary

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As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.

Detailed Description

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Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.

Conditions

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Covid19 Cognitive Impairment

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients

Subjects who have been Covid positive by RT-PCR at least 60 days ago and not having any symptoms of Covid-19 at the moment

No interventions assigned to this group

Healthy

Subjects who do not have any general medical, neurological or psychiatric disorder

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Covid-19 patients:

* Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago
* Asymptomatic at the moment
* Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection

Healthy subjects:

* Not having any of Covid-19 symptoms at the testing time point
* Not having any general medical, neurological or psychiatric condition

Exclusion Criteria

Covid-19 patients:

* Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago
* Having any symptom of acute phase of Covid-19
* Having any other general medical, neurlogical or psychiatric contidions

Healthy subjects:

* Having any of Covid-19 symptoms at the testing time point
* Having any general medical, neurological or psychiatric condition
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Mehmet Diyaddin Güleken

Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mehmet D Güleken, MD

Role: PRINCIPAL_INVESTIGATOR

Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Locations

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Sağlık Bilimleri Üniversitesi Gazi Yaşargil Training and Research Hospital

Diyarbakır, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Wilson BA, Betteridge S, Fish J. Neuropsychological consequences of Covid-19. Neuropsychol Rehabil. 2020 Oct;30(9):1625-1628. doi: 10.1080/09602011.2020.1808483. No abstract available.

Reference Type BACKGROUND
PMID: 32869697 (View on PubMed)

Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020 Oct;129:98-102. doi: 10.1016/j.jpsychires.2020.06.022. Epub 2020 Jun 30.

Reference Type BACKGROUND
PMID: 32912598 (View on PubMed)

Guo Q, Zheng Y, Shi J, Wang J, Li G, Li C, Fromson JA, Xu Y, Liu X, Xu H, Zhang T, Lu Y, Chen X, Hu H, Tang Y, Yang S, Zhou H, Wang X, Chen H, Wang Z, Yang Z. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study. Brain Behav Immun. 2020 Aug;88:17-27. doi: 10.1016/j.bbi.2020.05.038. Epub 2020 May 19.

Reference Type BACKGROUND
PMID: 32416290 (View on PubMed)

Other Identifiers

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21022021

Identifier Type: -

Identifier Source: org_study_id