Ciprofloxacin in Drug-resistant Epilepsy

NCT ID: NCT04763070

Last Updated: 2021-06-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-01

Study Completion Date

2021-06-01

Brief Summary

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This study aims to investigate the effect of a short-term prescription of ciprofloxacin on intestinal microbial pattern and seizure frequency of patients with drug-resistant epilepsy.

Detailed Description

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Conditions

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Epilepsy Intractable

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Ciprofloxacin

Group Type OTHER

Ciprofloxacin Oral Product

Intervention Type DRUG

The first stool sample will be taken before treatment and the second one will be taken in day 5 to 7 after treatment initiation. Treatment includes ciprofloxacin tablet 500mg twice a day for 5 days.

Interventions

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Ciprofloxacin Oral Product

The first stool sample will be taken before treatment and the second one will be taken in day 5 to 7 after treatment initiation. Treatment includes ciprofloxacin tablet 500mg twice a day for 5 days.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Drug-resistant epilepsy with frequency of at least 2 seizure/Week
* Acceptance of patients or his/her guardian (Signing informed consent)

Exclusion Criteria

* Hypersensitivity to ciprofloxacin or other fluoroquinolones
* History of tendon, renal, hepatic or cerebrovascular disease, organ transplantation or myasthenia gravis
* Usage of medications with interaction to ciprofloxacin
* No reliable contraception
* Pregnancy or breastfeeding
* Being under treatment with corticosteroid
* Usage of antibiotics in recent 2 months or need to use it during the study
* Patients who are candidate for epilepsy surgery or other nonmedical treatments
* Change in anti-seizure medications (ASMs) during recent month
* Patients who will need changes in ASMs dose during study
Minimum Eligible Age

16 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Mazandaran University of Medical Sciences

OTHER

Sponsor Role lead

Responsible Party

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Nasim Tabrizi

Associate professor of neurology

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Bu Ali Sina hospital

Sari, Mazandaran, Iran

Site Status

Countries

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Iran

Other Identifiers

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5210

Identifier Type: -

Identifier Source: org_study_id

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