Study of Metformin Overdose

NCT ID: NCT04762966

Last Updated: 2021-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-01

Study Completion Date

2021-09-01

Brief Summary

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The objective of the METINFO study is an observational single-center retrospective and descriptive study. The main objective is to estimate the real mortality rate associated to a Metformin overdose. Second objectives are to estimate the real hospitalization rate related to metformin overdose and to identify the risk factors of a metformin overdose and especially the potential correlation between metformin blood concentration and overdose severity.

Detailed Description

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Conditions

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Metformin Associated Lactic Acidosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Therapeutic

Patients with metformin blood concentration in the therapeutic ranges.

Metformin

Intervention Type DRUG

Level of Metformin blood concentration

Supratherapeutic

Patients with metformin blood concentration above the therapeutic ranges.

Metformin

Intervention Type DRUG

Level of Metformin blood concentration

Interventions

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Metformin

Level of Metformin blood concentration

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult patients benifiting of a metformin blood concentration determination in the period ranging from the 1st of July 2019 and the 1st of July 2021.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Central Hospital, Nancy, France

OTHER

Sponsor Role lead

Responsible Party

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SCALA-BERTOLA Julien

Dr Julien SCALA-BERTOLA

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital of Nancy

Vandœuvre-lès-Nancy, , France

Site Status RECRUITING

Countries

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France

Facility Contacts

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Julien SCALA-BERTOLA, Dr

Role: primary

0383656138

References

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Goonoo MS, Morris R, Raithatha A, Creagh F. Metformin-associated lactic acidosis: reinforcing learning points. BMJ Case Rep. 2020 Sep 2;13(9):e235608. doi: 10.1136/bcr-2020-235608.

Reference Type BACKGROUND
PMID: 32878828 (View on PubMed)

Walz L, Jonsson AK, Ahlner J, Ostgren CJ, Druid H. Metformin - Postmortem fatal and non-fatal reference concentrations in femoral blood and risk factors associated with fatal intoxications. Forensic Sci Int. 2019 Oct;303:109935. doi: 10.1016/j.forsciint.2019.109935. Epub 2019 Aug 28.

Reference Type BACKGROUND
PMID: 31491622 (View on PubMed)

Taub ES, Hoffman RS, Manini AF. Incidence and risk factors for hyperlactatemia in ED patients with acute metformin overdose. Am J Emerg Med. 2019 Dec;37(12):2205-2208. doi: 10.1016/j.ajem.2019.03.033. Epub 2019 Mar 23.

Reference Type BACKGROUND
PMID: 30967322 (View on PubMed)

Other Identifiers

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2021PI020

Identifier Type: -

Identifier Source: org_study_id

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