Obstructive Sleep Apnea and Comprehensive Remotely-supervised Rehabilitation Program

NCT ID: NCT04759456

Last Updated: 2025-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-25

Study Completion Date

2026-07-31

Brief Summary

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The purpose of this study is to investigate the feasibility and effect of a 12-week remotely-supervised rehabilitation program in male patients between 25-65 years old with newly diagnosed obstructive sleep apnea with Apnea-Hypopnea Index greater than 15 episodes per hour indicated to CPAP therapy.

Detailed Description

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The intervention group will undergo comprehensive remotely-supervised rehabilitaiton program in home conditions with teleconsultation (contains telecoaching, telemonitoring) via regular phone calls and e-mails at least 2 times a week. The intervention will include nutrition, health-related lifestyle and behavioral changes recommendations, and at least 5 times a week 30 minutes of moderate-intensity aerobic training, 10 minutes of inspiratory and expiratory muscle training with breathing device and 10 minutes of oropharyngeal exercise along with individually titrated CPAP therapy.

The control group will undergo individually titrated CPAP therapy only. The participants in both groups will go through the following assessments before and after this study: polysomnography, spirometry, anthropometry and body composition examination, laboratory values examination, quality of life questionnaires, Epworth sleepiness scale, 6-min walking test.

Conditions

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Obstructive Sleep Apnea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Intervention group

Participants will undergo 12-week comprehensive remotely-supervised rehabilitation program along with individually titrated CPAP therapy.

Group Type EXPERIMENTAL

Remotely-supervised rehabilitation program

Intervention Type OTHER

Include nutrition, health-related lifestyle and behavioral changes recommendations, and at least 5 times a week 30 minutes of moderate-intensity aerobic training, 10 minutes of inspiratory and expiratory muscle training with breathing device and 10 minutes of oropharyngeal exercise along with individually titrated CPAP therapy

Control group

Participants will undergo individually titrated CPAP therapy.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Remotely-supervised rehabilitation program

Include nutrition, health-related lifestyle and behavioral changes recommendations, and at least 5 times a week 30 minutes of moderate-intensity aerobic training, 10 minutes of inspiratory and expiratory muscle training with breathing device and 10 minutes of oropharyngeal exercise along with individually titrated CPAP therapy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* signed informed consent
* newly diagnosed obstructive sleep apnea
* Apnea-Hypopnea Index greater than 15 episodes/hour
* indicated for CPAP therapy

Exclusion Criteria

* severe pulmonary hypertension
* severe heart valve disease
* COPD III or IV
* central sleep apnea
* chronic corticosteroid therapy
* long-term oxygen therapy
* heart failure
* left ventricular ejection fraction lower than 40 %
* NYHA III or IV
* cerebrovascular disease
* psychiatric disease
* another type of obstructive sleep apnea treatment
* acute coronary syndrome in anamnesis
Minimum Eligible Age

25 Years

Maximum Eligible Age

65 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Brno University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jakub Hnatiak, MSc.

MSc.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital Brno

Brno, , Czechia

Site Status

Countries

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Czechia

References

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Hnatiak J, Zikmund Galkova L, Winnige P, Batalik L, Dosbaba F, Ludka O, Krejci J. Obstructive Sleep Apnea and a Comprehensive Remotely Supervised Rehabilitation Program: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2023 Sep 18;12:e47460. doi: 10.2196/47460.

Reference Type DERIVED
PMID: 37721786 (View on PubMed)

Other Identifiers

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NIG 2/20

Identifier Type: -

Identifier Source: org_study_id

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