Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy

NCT ID: NCT04758533

Last Updated: 2024-12-27

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 13 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-04-19
• Study Completion Date: 2026-04-30

Brief Summary

The aim of this study is to assess the safety and efficacy of AloCELYVIR, which consist in bone marrow-derived allogenic mesenchymal stem cells infected with an oncolytic Adenovirus, ICOVIR-5. It has recently been proven that this type of cells are able of transporting oncolytic substances to tumor targets that are difficult to reach, such as medulloblastomas and gliomas, youth cancers located in the cranial cavity that have a poor prognosis and a fatal outcome. In addition, to exerting an anti-tumor action, this virus has the ability to stimulate the immune response, making the therapy even more effective. Thus, the diffuse intrinsic pontine glioma and the medulloblastoma in relapse/progression have been chosen to study the potential of this new advanced therapy through a weekly infusion for 8 weeks.

Conditions

Diffuse Intrinsic Pontine Glioma; Medulloblastoma, Childhood, Recurrent

Keywords

Icovir-5; Mesenchymal stem cells; Medulloblastoma; Diffuse Intrinsic Pontine Glioma

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

AloCELYVIR

Patients will received weekly infusion of AloCELYVIR during 8 weeks.

Group Type: EXPERIMENTAL

AloCELYVIR

Intervention Type: BIOLOGICAL

Mesenchymal allogenic cells + ICOVIR-5: 500.000 cells/kg

Interventions

AloCELYVIR

Mesenchymal allogenic cells + ICOVIR-5: 500.000 cells/kg

Intervention Type: BIOLOGICAL

Eligibility Criteria

Inclusion Criteria

1. Patients aged 1 to 21 years.

2. Written informed consent signed by the patients legal representative and, if applicable, the minor (informed consent in patients 12 years of age or older).

3. Measurable or evaluable disease according to RANO criteria.

4. Appropriate functional status, organic function (renal, hepatic) and hematological values:

• Lanksy and karnofsky functional status ≥50%. Patients who use a wheelchair due of tumor-associated paralysis will be considered as outpatients for functional status evaluation.
• Haematology function:

• Platelet count ≥75.000/µL (without support for 3 days)
• Absolute neutrophil count (ANC) ≥500/ µL (without growth factor for 3 days)
• Hemoglobin ≥ 8 g/dL (Transfusion allowed)
• Liver and renal function

• Glomerular filtration rate (GFR) (estimated by Schwartz ) >60 mL/min/1.73 m2
• Total bilirubin ≤ 1.5 × the upper limit of normal (ULN)
• Transaminases (GOT and GPT) ≤3 × the upper limit of normal (ULN). ≤ 5 times ULN for patients with hepatic metastasis.

5. Patient able to comply with treatment and schedule of visits and assessments

6. Life expectancy of ≥8 weeks.

7. Appropriate contraceptive methods for sexually active males and females of childbearing age

8. Negative pregnancy test in blood or urine for females of childbearing age

1. Patient with new DIPG diagnosis (clinical, radiological, or histological in case a biopsy was performed before being included in the study).

2. Not having received previous treatment with radiotherapy or chemotherapy.

3. Patient able to receive radiotherapy

1. Patient diagnosed with relapsed and/or refractory medulloblastoma. Patients must have received at least surgery, radiation therapy and chemotherapy as part of standard treatment and have failed these treatments before they can participate in this study.

2. To be recovered to ≤ G1 from the toxic effects according to CTCAE derived from the previous treatments, excluding ototoxicity, alopecia and peripheral neurotoxicity.

Exclusion Criteria

1. Previous treatment with CELYVIR or AloCELYVIR.

2. Known active bacterial, viral, fungal or parasitic infection not controlled

3. Known active Hepatitis B or C virus or VIH infection.

4. If patients are treated with corticosteroids, they should be clinically stable and on stable or tapering doses of steroids for at least one week.

5. To be receiving another anti-cancer treatment not foreseen in this protocol or to anticipate receiving it during the patient's participation in the same concomitant with the experimental treatment.

6. Clinically significant or uncontrolled serious active and past systemic diseases that may pose an added risk to the patient

1. Spontaneous massive intratumoral bleeding. Patients with postoperative bleeding (in case of biopsy or surgery) may be included in the study provided that the bleeding is controlled. The same rule applies for other postoperative complications (infection, loss of cerebrospinal fluid, absence of wound closure, subdural collection ...)

2. Patients who have previously received radiotherapy to the brain stem for another malignancy

1. Washout period respect to previous treatments:

• At least two weeks since the last dose of chemotherapy. For patients receiving low-dose metronomic oral chemotherapy, this period is at least one week.
• At least four weeks since the autologous hematopoietic stem cell transplant
• At least two weeks since the last focal radiotherapy or six weeks in case of cranio-spinal radiotherapy.
• At least 2 weeks or 5 half-lifes (whichever occurs first) since the last dose of a biological or investigational treatment.

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 21 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Apices Soluciones S.L.

INDUSTRY

Sponsor Role: collaborator

Hospital Infantil Universitario Niño Jesús, Madrid, Spain

OTHER

Sponsor Role: lead

Responsible Party

Mrs. Laura Aranzasti

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Álvaro Lassaletta Atienza, MD

Role: STUDY_CHAIR

Hospital Infantil Universitario Niño Jesús

Locations

Hospital Infantil Universitario Niño Jesús

Madrid, , Spain

Countries

Spain

Other Identifiers

2020-004838-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

2022-502516-37-00

Identifier Type: CTIS

Identifier Source: secondary_id

FIBHNJ-2020-01

Identifier Type: -

Identifier Source: org_study_id