Study on the Value of Non-invasive Dual-Pet Information in Subtype of Metastatic Breast Cancer

NCT ID: NCT04758416

Last Updated: 2022-04-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-31

Study Completion Date

2022-12-31

Brief Summary

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Study on the Value of Non-invasive Dual-Pet(18F-FES PET and 68Ga-HER2-Affibody PET) Information in Subtype of Metastatic Breast Cancer

Detailed Description

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A Phase II, Single-center STudy on the vAlue of Non-invasive Dual-Pet(18F-FES PET and 68Ga-HER2-Affibody PET)InformatiOn IN Subtype of Metastatic Breast Cancer(MBC)

Conditions

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Breast Cancer

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Metastatic breast cancer patients

50 metastatic breast cancer patients

biopsy or surgical pathology in metastases

Intervention Type PROCEDURE

biopsy or surgical pathology in extrahepatic/liver/brain metastases

68Ga-HER2 affibody,18F-FDG, 18F-FES

Intervention Type DRUG

68Ga-NOTA-MAL-MZHER2 (68Ga-HER2) affibody is an investigational Positron Emission Tomography (PET)/ Computed Tomography (CT) radiopharmaceutical.

Interventions

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biopsy or surgical pathology in metastases

biopsy or surgical pathology in extrahepatic/liver/brain metastases

Intervention Type PROCEDURE

68Ga-HER2 affibody,18F-FDG, 18F-FES

68Ga-NOTA-MAL-MZHER2 (68Ga-HER2) affibody is an investigational Positron Emission Tomography (PET)/ Computed Tomography (CT) radiopharmaceutical.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Subjects voluntarily joined the study, signed informed consent, and had good compliance.
2. Female patients aged over 18 years (including cutoff value).
3. an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
4. Recurrence or metastatic breast cancer confirmed by histopathology, or expect to be feasible metastasis puncture or surgery to confirm histopathological recurrence or metastatic breast cancer.

Exclusion Criteria

1. Pregnancy or lactation.
2. Alcohol allergy is not suitable for FES-PET/ C.
3. There are contraindications for patients who are expected to have metastasis puncture or surgery.
4. Mental disorders or other conditions affecting patient compliance.
Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Xichun Hu

Director of department of medical oncology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xichun Hu, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Fudan University

Locations

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Shanghai Cancer Center Institutional Review Board

Shanghai, Shanghai Municipality, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xichun Hu, MD, PhD

Role: CONTACT

64175590 ext. 5006

Jian Zhang, M.D.

Role: CONTACT

64175590 ext. 85000

Facility Contacts

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Xichun Hu, MD, PhD

Role: primary

64175590 ext. 5006

Other Identifiers

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STANDPOINT

Identifier Type: -

Identifier Source: org_study_id

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