Validation of the Two-minute Walk Test and the Ten-meter Walk Test in Individuals With Cancer

NCT ID: NCT04750148

Last Updated: 2023-01-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

56 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-15

Study Completion Date

2021-03-31

Brief Summary

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The aim of this study is to assess the feasibility and the validity of the 2-minute walk test (2MWT) and the 10-meter walk test (10MeWT) compared to the 6-minute walk test (6MWT) for subjects with onco-hematological disease.

Detailed Description

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Cancer and its treatments have an impact on the body as a whole. The analysis of the subject's physical capacity is essential to know the basic level of the subject pre-treatment, to evaluate progress following rehabilitation, to set goals to prevent decline in physical capacity or to evaluate changes in physical capacity at different stages of survival. The 6-minute walk test (6MWT) is frequently used in the clinic to assess the physical capacity of the subject in oncology. A variant of the 6MWT exists and has been little studied in an oncological context: the 2-minute walk test (2MWT). The 2MWT is performed in the same way as the 6MWT: the same instructions and the same test procedure. It offers the advantage of being less tiring for the test subjects and saves clinicians time. The 2MWT has been validated in the past for people with COPD or after cardiac surgery. To our knowledge, it has not been validated for cancer patients.

The 10-meter walk test (10MeWT) is frequently used in practice to assess patients' functional capacity. It would be another way to assess the walking ability with a short test.

However, the relationship between the 2MWT, 6MWT and 10MeWT in an oncological context remain unclear.

Conditions

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Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cancer

Individuals with an oncology disease will be included in the study.

6-minute walking test

Intervention Type DIAGNOSTIC_TEST

The subject walks as far as possible for 6 minutes along a 30m long corridor.

2-minute walking test

Intervention Type DIAGNOSTIC_TEST

The subject walks as far as possible for 2 minutes along a 30m long corridor.

10-meter walk test

Intervention Type DIAGNOSTIC_TEST

The natural and fast walking speeds of the subject are measured over 10m. This speed is measured by the examiner as well as by the subject (self-tested version).

One leg stance test

Intervention Type DIAGNOSTIC_TEST

The time held in unipodal equilibrium is measured by the examiner.

Interventions

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6-minute walking test

The subject walks as far as possible for 6 minutes along a 30m long corridor.

Intervention Type DIAGNOSTIC_TEST

2-minute walking test

The subject walks as far as possible for 2 minutes along a 30m long corridor.

Intervention Type DIAGNOSTIC_TEST

10-meter walk test

The natural and fast walking speeds of the subject are measured over 10m. This speed is measured by the examiner as well as by the subject (self-tested version).

Intervention Type DIAGNOSTIC_TEST

One leg stance test

The time held in unipodal equilibrium is measured by the examiner.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Have an onco-hematologic disease
* Have medical authorization from the patient's oncologist authorizing gait tests
* Participate in the HUG rehabilitation program
* Be able to give consent by signature
* To be of legal age
* Do not present pain when walking more than 2/10
* Be able to walk with or without technical aids for a period of 6 minutes (as per patient's statement)

Exclusion Criteria

* Suffer from heart problems
* Bone metastases at risk of fracture
* Osteoporosis at high risk of fracture
* Unbalanced Hypertension (hypertension)
* Not being able to carry out the walk tests in their entirety
* Not being able to perform the gait tests for reasons related to the side effects of the treatments (anemia, undernutrition, vomiting, severe fatigue, risk of thrombocytopenia, pain).
* Not being able to carry out the walking test because of a lack of understanding of the instructions or because of psychological problems.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aline Reinmann

OTHER

Sponsor Role lead

Responsible Party

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Aline Reinmann

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Aline Reinmann

Role: PRINCIPAL_INVESTIGATOR

School of Health Sciences Geneva

Locations

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Geneva University Hospitals

Geneva, , Switzerland

Site Status

Countries

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Switzerland

References

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Bohannon RW, Bubela D, Magasi S, McCreath H, Wang YC, Reuben D, Rymer WZ, Gershon R. Comparison of walking performance over the first 2 minutes and the full 6 minutes of the Six-Minute Walk Test. BMC Res Notes. 2014 Apr 25;7:269. doi: 10.1186/1756-0500-7-269.

Reference Type BACKGROUND
PMID: 24767634 (View on PubMed)

Butland RJ, Pang J, Gross ER, Woodcock AA, Geddes DM. Two-, six-, and 12-minute walking tests in respiratory disease. Br Med J (Clin Res Ed). 1982 May 29;284(6329):1607-8. doi: 10.1136/bmj.284.6329.1607. No abstract available.

Reference Type BACKGROUND
PMID: 6805625 (View on PubMed)

Chan WLS, Pin TW. Reliability, validity and minimal detectable change of 2-minute walk test, 6-minute walk test and 10-meter walk test in frail older adults with dementia. Exp Gerontol. 2019 Jan;115:9-18. doi: 10.1016/j.exger.2018.11.001. Epub 2018 Nov 10.

Reference Type BACKGROUND
PMID: 30423359 (View on PubMed)

Eden MM, Tompkins J, Verheijde JL. Reliability and a correlational analysis of the 6MWT, ten-meter walk test, thirty second sit to stand, and the linear analog scale of function in patients with head and neck cancer. Physiother Theory Pract. 2018 Mar;34(3):202-211. doi: 10.1080/09593985.2017.1390803. Epub 2017 Oct 25.

Reference Type BACKGROUND
PMID: 29068767 (View on PubMed)

Gijbels D, Eijnde BO, Feys P. Comparison of the 2- and 6-minute walk test in multiple sclerosis. Mult Scler. 2011 Oct;17(10):1269-72. doi: 10.1177/1352458511408475. Epub 2011 Jun 3.

Reference Type BACKGROUND
PMID: 21642370 (View on PubMed)

Kosak M, Smith T. Comparison of the 2-, 6-, and 12-minute walk tests in patients with stroke. J Rehabil Res Dev. 2005 Jan-Feb;42(1):103-7. doi: 10.1682/jrrd.2003.11.0171.

Reference Type BACKGROUND
PMID: 15742254 (View on PubMed)

Leung AS, Chan KK, Sykes K, Chan KS. Reliability, validity, and responsiveness of a 2-min walk test to assess exercise capacity of COPD patients. Chest. 2006 Jul;130(1):119-25. doi: 10.1378/chest.130.1.119.

Reference Type BACKGROUND
PMID: 16840391 (View on PubMed)

Reid L, Thomson P, Besemann M, Dudek N. Going places: Does the two-minute walk test predict the six-minute walk test in lower extremity amputees? J Rehabil Med. 2015 Mar;47(3):256-61. doi: 10.2340/16501977-1916.

Reference Type BACKGROUND
PMID: 25588644 (View on PubMed)

Scalzitti DA, Harwood KJ, Maring JR, Leach SJ, Ruckert EA, Costello E. Validation of the 2-Minute Walk Test with the 6-Minute Walk Test and Other Functional Measures in Persons with Multiple Sclerosis. Int J MS Care. 2018 Jul-Aug;20(4):158-163. doi: 10.7224/1537-2073.2017-046.

Reference Type BACKGROUND
PMID: 30150899 (View on PubMed)

Schmidt K, Vogt L, Thiel C, Jager E, Banzer W. Validity of the six-minute walk test in cancer patients. Int J Sports Med. 2013 Jul;34(7):631-6. doi: 10.1055/s-0032-1323746. Epub 2013 Feb 26.

Reference Type BACKGROUND
PMID: 23444095 (View on PubMed)

Other Identifiers

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2020-00126

Identifier Type: -

Identifier Source: org_study_id

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