Saffron as Anti Inflammatory Agent In Patients With Inflammatory Bowel Disease

NCT ID: NCT04749576

Last Updated: 2021-02-11

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 100 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-12-15
• Study Completion Date: 2023-12-10

Brief Summary

Nutritional Saffron supplement has been widely used as food supplement and has known anti-depressant and anti-inflammatory activities. It is generally consumed as stigmas in drinks or dishes. The investigators use saffron extract in patients with colitis for 8 weeks.

Detailed Description

The patients invited to participate in a research study on Inflammatory Bowel Diseases (IBD) and saffron as a nutritional anti-inflammatory supplement.

Inflammatory Bowel Disease (IBD) is composed of Crohn's Disease (CD) and Ulcerative Colitis (UC). Continuous altered immune responses and inflammation associate with this disease. More than two-thirds of patients reported that IBD-associated symptoms negatively affected their quality of life and their performance at work.

• Patients with IBD are generally put on immunosuppressants (that block or slow participants' immune system to lower the level of inflammation). Long-term use of these immunosuppressants have some serious side effects.
• The goal of this protocol is to lower the need for these immunosuppressants by giving saffron as capsules in two different doses. The investigators will assess whether the addition of saffron will improve the overall patient's status and decrease the need for immunosuppressants. If participants have been prescribed immunosuppressants by the participant's doctor, saffron will be added to the participants' treatment.
• The investigators request that the subject answer as many questions as they can during this visit. If they are unable to complete the questionnaires during this visit, the investigators ask them to please return them within 7 days. If the investigators do not receive the questionnaires, the investigators will make one phone call to remind the subjects to send the questionnaires back.
• The subject medical record and colonoscopy report will be used to determine IBD or health status, the blood sample will be used to assess immune markers (inflammatory and antiinflammatory), stool sample will be used to assess some inflammation markers and saffron effect on the intestinal bacterial composition, a saliva sample will be used to assess whether saffron selectively affects the intestinal bacteria but not the saliva bacteria and the urine sample will be used to assess saffron release in body fluids.
• Participants are being asked to participate in this research project because participants are having a normal colonoscopy for screening, or IBD.
• If a biopsy is taken at colonoscopy. a pathologist will use a portion to make a diagnosis. The investigators are requesting permission to use a portion of the excess tissue that the pathologist does not need, for this research project.
• Samples will be collected at baseline (day 0) and 8 weeks later after saffron capsules utilization.
• This is a double-blind clinical trial, you will not know whether participants are given a placebo (capsule without saffron) or saffron dose 1 or 2. This is important for participants and for the study process, to avoid any psychological effect on the expected saffron effect.
• However, by the end of the 8 weeks and after collecting and analyzing the data from all participants, the investigators will inform the subject of what the subjects were given and potential next steps.

Conditions

Ulcerative Colitis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Low dose saffron

healthy, mild-moderate ulcerative colitis for low dose

Group Type: ACTIVE_COMPARATOR

saffron supplement for IBD

Intervention Type: DIETARY_SUPPLEMENT

anti inflammatory effect

High dose Saffron

healthy, mild-moderate ulcerative colitis for high dose

Group Type: ACTIVE_COMPARATOR

saffron supplement for IBD

Intervention Type: DIETARY_SUPPLEMENT

anti inflammatory effect

Placebo

healthy, mild-moderate ulcerative colitis for placebo

Group Type: PLACEBO_COMPARATOR

saffron supplement for IBD

Intervention Type: DIETARY_SUPPLEMENT

anti inflammatory effect

Interventions

saffron supplement for IBD

anti inflammatory effect

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

1. Male or female patients aged >18 years

2. Have UC diagnosed at least 3 months prior to screening? The diagnosis of UC must be confirmed by endoscopic and histologic evidence.

3. Men and women of childbearing potential must agree to use adequate birth control measures during the study.

4. Ability to provide written informed consent and to be compliant with the schedule of protocol assessments, treatment plan, laboratory tests, and other study procedures.

5. UC patients with mild, mod, severity as assess by the 4 scale assessment (Normal, mild, mod, severe).

6. Treatment naïve subjects diagnosed with ulcerative colitis (without previous exposure to treatment).

7. UC patients already on a treatment might be considered, with saffron as an add-on 8. UC patients who displayed no improvement with any available treatment might be considered for saffron as an alternative treatment in this option.

Exclusion Criteria

1. Patients taking immunosuppressive medicine for a disease other than UC

2. Rheumatologic disease and other underlying diseases that can interfere with the study process.

3. Pregnancy

4. If the UC has been present for > 10 years, a colonoscopy with biopsy has to be performed to rule-out dysplasia.

5. A subject who had surgery as a treatment for ulcerative colitis or likely to require surgery during the study period.

6. Subjects with evidence of liver disease or abnormal liver enzymes and function tests (e.g. total bilirubin, aspartate aminotransferase (AST) or alanine aminotransferase (ALT) higher than the upper limit of normal) at the screening visit.

7. Subjects who have any condition possibly affecting oral nutritional supplement absorption.

8. Any other condition which in the opinion of the investigators would make the subject unsuitable for inclusion in the study.

9. Patients with known active or untreated GI infections including C. difficile, CMV, HSV, HIV

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Howard University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Hassan Ashktorab

Role: STUDY_CHAIR

Howard Uinversity

Locations

Howard University Hospital

Washington D.C., District of Columbia, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Hassan Ashktorab

Role: CONTACT

hashktorab@howard.edu

2028066121

Hassan Brim

Role: CONTACT

hbrim@howard.edu

2028064198

Facility Contacts

Hassan Ashktorab

Role: primary

hashktorab@howard.edu

202-806-6121

Hassan Brim

Role: backup

hbrim@howard.edu

2028064198

References

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Reference Type: RESULT

Other Identifiers

HowardU

Identifier Type: -

Identifier Source: org_study_id