Neuro-ultrasound Assessment in Behcet's Disease

NCT ID: NCT04738864

Last Updated: 2021-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-31

Study Completion Date

2021-08-31

Brief Summary

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Assessment of structural changes that occur in large extracranial and intracranial arteries in patients with Behcet's disease

Detailed Description

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Patients will be selected from Rheumatology and Rehabilitation inpatient and outpatient clinics in Assiute University Hospital Patients under 16 years old, patients with hyperlipidemia, hypertension, diabetes mellitus and all other risk factors affecting blood vessel intimal thickness will be excluded from the research.

All patients and control groups underwent a complete extracranial and intracranial ultrasound assessment by 2 experienced neurovascular sonographers .The ultrasound examination was done at the Neurovascular Ultrasound Laboratory in the Neurology department, Assiut University hospitals using a color-coded duplex ultrasound device Philips HD5 (Philips Medical Systems, Nederland B.V.) for the carotid and vertebral arteries and for the intracranial arteries.

Intimal medial thickness (IMT) of the common carotid artery (CCA), peak systolic velocities (PSVs) and end diastolic velocities (EDVs) were measured in the common, internal, and external carotid arteries (CCA, ICA, ECA) with L 3-12 MHz linear transducer probe and when stenosis was detected the velocities were measured at the maximally stenotic area.

The intracranial arteries were evaluated in all patients with transcranial color-coded duplexsonography (TCCS) with the use of a low-frequency (2- to 5-MHz) phased-array probe through the transtemporal acoustic bone window. The middle cerebral artery (MCA), intracranial segment of vertebral artery (V4)and basilar artery (BA) were examined. Peak systolic velocity (PSV) and flow direction (antegrade or reversed) used for the diagnosis of any intracranial atherosclerotic disease (ICAD).

The findings and the atherosclerotic changes in the extracranial and intracranial vessels were interpreted according to the internationally published data Data will be analyzed using the computer program SPSS

Conditions

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Behcet Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

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behcet's disease patient

patient who presented with manifestation of behcet disease

Group Type EXPERIMENTAL

ultrasound

Intervention Type DIAGNOSTIC_TEST

extracranial and intracranial ultrasound assessment

Healthy people

healthy control people

Group Type EXPERIMENTAL

ultrasound

Intervention Type DIAGNOSTIC_TEST

extracranial and intracranial ultrasound assessment

Interventions

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ultrasound

extracranial and intracranial ultrasound assessment

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* patient more than 18 years old
* All patients fulfill the modified International Criteria for Behçet's Disease

Exclusion Criteria

* Patients under 16 years old,
* patients with hyperlipidemia, hypertension, diabetes mellitus and all other risk factors affecting blood vessel intimal thickness
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Esraa Ahmed Talaat

lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Esraa A Talaat, Lecturer

Role: STUDY_CHAIR

Assiut University

Locations

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Medicine

Asyut, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Esraa A Talaat, lecturer

Role: CONTACT

01003314717 ext. 0882413177

Shady M Safwat, Lecturer

Role: CONTACT

01008763141

Facility Contacts

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vice V president, proffesor

Role: primary

00208822080150

Other Identifiers

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17300548

Identifier Type: -

Identifier Source: org_study_id

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