Shock Wave Versus Iontophoresis in Treatment of Subjects With Knee Osteoarthritis

NCT ID: NCT04731350

Last Updated: 2023-03-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-01-20
• Study Completion Date: 2023-01-15

Brief Summary

Both extra corporeal shock wave and dexamethasone iontophoresisare effective in treatment of knee osteoarthritis but which one is more effective is not clear yet . so the purpose of this study was to investigate and compare between the effect of shock wave and iontophoresis in treatment of knee osteoarthritis . it was hypothesized that there will be no difference between the effect of shock wave and iontophoresis on treatment of knee osteoarthritis.

Detailed Description

60 subjects with grade II knee osteoarthritis will be recruited from outpatient clinic of faculty of physical therapy and then they will be assigned randomly by sealed envelope into three groups ;group A (shock wave group) will received radial extracorporeal shock wave ,group B (Iontophoresis group ) will receive deaxamthasone iontophoresis and group c (control group) will receive traditional tratment ( stregnthening exerciseces) all treatment will be once session per week for four weeks .pain intensity ,knee ROM and knee injury and osteoarthritis outcome score physical function short (KOOS-PS).

Conditions

Knee Osteoarthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Shock wave(A)

subjects will recive radial extracorporeal shock wave (2000 shock/session, 10Hz and EFD 0.178 mJ/mm²) on knee joints once per week for four weeks in addition to strengthening exercise

Group Type: EXPERIMENTAL

radial extracorporeal shock wave

Intervention Type: DEVICE

Radial shock wave device, Swiss DolorClast (EMS Electro Medical Systems, Nyon, Switzerland)

Exercise

Intervention Type: OTHER

strengthening exercise

Iontophoresis (B)

subjects will recive dexamethasone iontophoresis on knee joints once per week for four weeks in addition to strengthening exercise

Group Type: EXPERIMENTAL

iontophoresis

Intervention Type: DEVICE

Iontophoretic drug delivery system (phoresors II auto model PM850 IOMED):

Exercise

Intervention Type: OTHER

strengthening exercise

Control (C)

stregnthening exercise;straight leg raising exercisein which the patients were positioned in the crook lying position with the unexercised limb was the flexed one then the patients were asked to contract the quadriceps muscle and elevate the limb to 45º and hold for 6 seconds, slowly lower the limb and then relax for 6 seconds, three sets of 10 repetitions were don ,Isometric quadriceps contraction (quadriceps drill) in full knee extension maintained for 5 seconds, followed by a 5-second rest; the exercise was performed for 20 repetitions per session .treatment once per week for four weeks

Group Type: OTHER

Exercise

Intervention Type: OTHER

strengthening exercise

Interventions

radial extracorporeal shock wave

Radial shock wave device, Swiss DolorClast (EMS Electro Medical Systems, Nyon, Switzerland)

Intervention Type: DEVICE

iontophoresis

Iontophoretic drug delivery system (phoresors II auto model PM850 IOMED):

Intervention Type: DEVICE

Exercise

strengthening exercise

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Symptomatic knee OA for at least 3 months according to clinical criteria of American College of Rheumatology

2. Radiologic findings had to be compatible with knee OA, with kelgren and Lawrence (K-L) grade 2 in a simple X ray .

3. Tenderness on medial tibial plateau

4. Intensity of pain: visual analogue scale equal to 5 or greater

5. Failure of two or more types of previous conservative treatment (medication, anti-inflammatory drugs, physical therapy, stretching, acupuncture, orthotics and others)

Exclusion Criteria

1. Neuorological and vestibular system disorder, systematic inflammatory disease, steroid injections in the last six months

2. Any contraindication to magnetic resonance imaging or radiography, or trauma history on knee

3. history of previous knee surgery -

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cairo University

OTHER

Sponsor Role: lead

Responsible Party

Shimaa Taha Abu El Kasem

principle investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Faculty of physical therapy ,Cairo University

Giza, , Egypt

Countries

Egypt

Other Identifiers

REC/012/002633

Identifier Type: -

Identifier Source: org_study_id