The Potential Use of Inhaled Hydroxychloroquine for the Treatment of COVID-19 in Cancer Patients

NCT ID: NCT04731051

Last Updated: 2023-04-07

Basic Information

• Recruitment Status: WITHDRAWN
• Clinical Phase: PHASE1/PHASE2
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-10-31
• Study Completion Date: 2022-12-31

Brief Summary

This is a pilot, randomized, single-center, parallel group, open-label controlled study to evaluate the feasibility, safety, efficacy, and pharmacokinetics of nebulized HCQ01 plus Standard of Care (SOC) versus SOC alone in hospitalized cancer patients with COVID-19. King Hussein Cancer Center (KHCC) is the study sponsor, and the study will be conducted at KHCC COVID-19 wards.

Approximately 28 cancer patients, ≥18 years of age with a confirmed SARS-CoV-2 infection, will be enrolled and randomized 1:1 to the treatment and control arms where they will receive ten doses of Hydroxychloroquine solution via nebulizer in addition to SOC or the control arm where treatment will follow KHCC SOC.

Conditions

2019 Novel Coronavirus

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

First Arm (Hydroxychloroquine sulfate, 5 days)

Participants will receive continued standard of care therapy (SOC) for COVID-19 together with 2 ml HCQ01 (12.5 mg/ml) twice a day for 5 consecutive days.

Group Type: EXPERIMENTAL

HCQ01

Intervention Type: DRUG

HCQ01 is a sterile, clear and colorless, ready-to-use aqueous nebulizer solution. Hydroxychloroquine sulfate administered via nebulization

standard of care (SOC) for COVID-19

Intervention Type: DRUG

Standard of care (SOC) for COVID-19

Second Arm (Continued Standard of Care (SOC) Therapy)

Participants will receive continued standard of care therapy for COVID-19

Group Type: ACTIVE_COMPARATOR

standard of care (SOC) for COVID-19

Intervention Type: DRUG

Standard of care (SOC) for COVID-19

Interventions

HCQ01

HCQ01 is a sterile, clear and colorless, ready-to-use aqueous nebulizer solution. Hydroxychloroquine sulfate administered via nebulization

Intervention Type: DRUG

standard of care (SOC) for COVID-19

Standard of care (SOC) for COVID-19

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

1. Documented informed consent of the patient and/or legally authorized representative. Assent, when appropriate, will be obtained per institutional guidelines.

2. Male or female ≥18 years of age at time of enrolment.

3. History of/ or active histologically or cytologically confirmed diagnosis of hematological or solid tumor (any type, any stage and any localization).

4. Eastern Cooperative Oncology Group (ECOG) Status < or = 3 (Appendix I).

5. Patients must have an active cancer treatment or have completed therapy within 12 months of initiation of protocol specified therapy. This includes:

• Patients with a new cancer diagnosis who have not yet initiated cancer therapy.
• Patients on active or have recently completed cancer-directed therapy including chemotherapy, targeted therapy, radiation therapy, immunotherapy or hormonal therapy amongst others which would not increase the risk of having an adverse outcome from participating in this study.

6. Currently hospitalized with laboratory-confirmed SARS-CoV-2 infection as determined by polymerase chain reaction (PCR) collected within one week prior to randomization.

7. Initial COVID-19 severity status on the WHO 11-point Ordinal Scale for Clinical Improvement = 4 ("Hospitalized; no oxygen therapy "), = 5 ("Hospitalized; oxygen by mask or nasal prongs "), or 6 ("Hospitalized; oxygen by NIV or high flow ") (Appendix II).

8. COVID-19-induced pneumonia evidenced by chest X-ray, computed tomography scan (CT scan) or magnetic resonance scan (MR scan).

9. Estimated life expectancy of at least 6 months at hospital admission for COVID-19.

10. Patients must be receiving standard of care for SARS-CoV-2.

11. Patients must have an assessment of adequate organ function within 28 days prior to enrolment, evidenced by:

• Hemoglobin ≥ 9.0 g / dL.
• Leukometry> 2,000 / mm3 (> 2 10E3/ ul).
• Absolute neutrophil count ≥ 1,500 / mm3 (≥1.5 10E3/ul).
• Platelet count ≥ 100,000 / mm3 (≥100 10E3/ul).
• Creatinine clearance ≥ 30 mL / min. Creatinine clearance (CrCl) should be calculated according to the Cockcroft-Gault formula.
• Total bilirubin <3 x the upper limit of normal (ULN), except for patients with known Gilbert's syndrome.
• Aspartate aminotransaminase (AST) <3.0 x LSN.
• Alanine aminotransaminase (ALT) <3.0 x ULN.

Exclusion Criteria

1. Pregnant (positive β-human chorionic gonadotropin test, β-HCG) or lactating female at screening.

2. Patients with a history of retinopathy, sickle cell disease or trait, psoriasis, porphyria, history of splenectomy, mental illness or uncontrolled seizures disorder, known active tuberculosis or history of incompletely treated tuberculosis, patients on chronic immunosuppression for other medical conditions such as rheumatological disorders, inflammatory bowel disease, or in patients with organ transplants.

3. Patients admitted in ICU.

4. Taking medications which may lead to interactions with hydroxychloroquine, including penicillamine, telbivudine, botulinum toxin, fluconazole, digoxin, propafenone , cimetidine, statins, warfarin, and cyclosporine within 2 weeks of dosing start, and during the duration of the study.

5. History of Glucose-6-phosphate dehydrogenase deficiency.

6. Pre-treatment corrected QT interval (QTc) ≥450 milliseconds.

7. Acute or chronic kidney disease (stage-4 or -5 renal impairment; eGFR<30 mL/min/1.73 m2 or hemodialysis).

8. Liver Child-Pugh grade C.

9. Patients with Hypokalemia (<3.6 mg/dl), Hypocalcemia (<8.8 mg/dl), Hypomagnesemia (<1.7 mg/dl). Will be included after correction.

10. Need for mechanical ventilation.

11. History of hypersensitivity to hydroxychloroquine.

12. History of Chronic Hepatitis B or hepatitis C infections.

13. History of Human Immunodeficiency Virus (HIV) infection.

14. Concurrent serious illness including, but not limited to, any of the following:

• Clinically significant cardiovascular disease (e.g., uncontrolled hypertension, myocardial infarction, or unstable angina).
• New York Heart Association class II-IV congestive heart failure.
• Serious cardiac arrhythmia requiring medication.
• Peripheral vascular disease ≥ grade 2 within the past year.
• Psychiatric illness/social situation that would limit compliance with study requirements.
• COPD, Lung cancer, and moderate to severe asthma.

15. Any other significant finding based on the judgment of the PI would increase the risk of having an adverse outcome from participating in this study.

16. Any other concomitant treatment based on the judgment of the PI would increase the risk of having an adverse outcome from participating in this study.

17. Is currently participating in or has participated in an interventional clinical trial with an investigational compound or device within 80 days of signing the informed consent/assent for this current trial.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Amman Pharmaceutical Industries (API)

UNKNOWN

Sponsor Role: collaborator

Sana Pharmaceutical Industry

UNKNOWN

Sponsor Role: collaborator

ACDIMA Biocenter

OTHER

Sponsor Role: collaborator

King Hussein Cancer Center

OTHER

Sponsor Role: lead

Responsible Party

Feras Hawari

Consultant in Pulmonary and Critical Care

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Feras Hawari, MD

Role: PRINCIPAL_INVESTIGATOR

King Hussein Cancer Center

Locations

King Hussein Cancer Center

Amman, , Jordan

Countries

Jordan

Other Identifiers

HYDR0121/CCO

Identifier Type: -

Identifier Source: org_study_id