Prospective Multicenter Registry on the Endovascular Treatment in Critical Limb Threatening Ischemia With Below the Knee Lesions With Wound, Ischemia, and Foot Infection (WIFI) Assessment

NCT ID: NCT04710420

Last Updated: 2024-07-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

842 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-01

Study Completion Date

2024-06-30

Brief Summary

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This is a prospective multicenter clinical study that used WIFI grading scores at different periods to evaluate the therapeutic value of endovascular therapy and this grading system for Chronic limb-threatening ischemia.

Detailed Description

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Conditions

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Chronic Limb-threatening Ischemia Endovascular Therapy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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WIfI stage 1

Very low risk of amputation was determined according to the SVS WIfI classification system.

Endovascular therapy

Intervention Type DEVICE

Endovascular treatment for critical limb threatening Ischemia

WIfI stage 2

Low risk of amputation was determined according to the SVS WIfI classification system.

Endovascular therapy

Intervention Type DEVICE

Endovascular treatment for critical limb threatening Ischemia

WIfI stage 3

Moderate risk of amputation was determined according to the SVS WIfI classification system.

Endovascular therapy

Intervention Type DEVICE

Endovascular treatment for critical limb threatening Ischemia

WIfI stage 4

High risk of amputation was determined according to the SVS WIfI classification system.

Endovascular therapy

Intervention Type DEVICE

Endovascular treatment for critical limb threatening Ischemia

Interventions

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Endovascular therapy

Endovascular treatment for critical limb threatening Ischemia

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. patients \> 18 years of age;
2. patients with Chronic limb-threatening ischemia (CLTI);
3. patients with below-the-knee lesions undergoing endovascular treatment;
4. target limbs with certain WIfI stage;
5. patients voluntary and capable of follow-up;
6. informed consent.

Definition of CLTI:

A diagnosis of CLTI requires objectively documented atherosclerotic PAD in association with ischemic rest pain or tissue loss (ulceration or gangrene).

Exclusion Criteria

1. Contraindication for antiplatelet , anticoagulant or thrombolytic agent;
2. Contrast agent allergy;
3. Dysfunctional protein C, protein S, antithrombin Ⅲ(AT Ⅲ) or refusal of blood transfusion;
4. Complications affecting surgical safety;
5. Major amputation was adopted to the target extremity;
6. The existence of aneurysm in the target vessels;
7. The existence of perforation, dissection or any other injury requiring intervention in the target vessels.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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RenJi Hospital

OTHER

Sponsor Role collaborator

Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology

OTHER

Sponsor Role collaborator

Zhejiang University

OTHER

Sponsor Role collaborator

First Affiliated Hospital of Zhejiang University

OTHER

Sponsor Role collaborator

Second Affiliated Hospital of Soochow University

OTHER

Sponsor Role collaborator

Qingdao Haici Hospital

OTHER

Sponsor Role collaborator

Hospital of Chengdu University of Traditional Chinese Medicine

UNKNOWN

Sponsor Role collaborator

Fudan University

OTHER

Sponsor Role collaborator

Huashan Hospital

OTHER

Sponsor Role collaborator

Xuanwu Hospital, Beijing

OTHER

Sponsor Role lead

Responsible Party

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Lian-Rui Guo

Director, vascular suregry department

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Xuanwu Hospital

Beijing, Beijing Municipality, China

Site Status

Countries

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China

Other Identifiers

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PRIME-WIFI

Identifier Type: -

Identifier Source: org_study_id

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