Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
30 participants
OBSERVATIONAL
2021-01-08
2022-02-01
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Study group
endometrial polyp
Beclin 1 gene
The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.
Control group
normal endometrium
Beclin 1 gene
The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.
Interventions
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Beclin 1 gene
The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* patients over the age of 35 whose histopathologically reported normal endometrial biopsy results.
Exclusion Criteria
* those with cognitive dysfunction,
* diagnosed with any type of cancer
* who are under treatment for cancer,
* diabetes mellitus,
* hypertension,
* endometriosis,
* adenomyosis,
* chronic endometritis,
* have an acute or chronic illness,
* patients who have smoked and used alcohol in the last 10 years
35 Years
FEMALE
Yes
Sponsors
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Muğla Sıtkı Koçman University
OTHER
Responsible Party
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Burak Sezgin
Principal investigator M.D. Burak Sezgin
Principal Investigators
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Burak SEZGİN, MD
Role: PRINCIPAL_INVESTIGATOR
Muğla Sıtkı Koçman University
Locations
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Mugla Sıtkı Kocman University Faculty of Medicine
Muğla, , Turkey (Türkiye)
Countries
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References
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Zhang J. Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches. Redox Biol. 2015;4:242-59. doi: 10.1016/j.redox.2015.01.003. Epub 2015 Jan 13.
Zhan L, Yao S, Sun S, Su Q, Li J, Wei B. NLRC5 and autophagy combined as possible predictors in patients with endometriosis. Fertil Steril. 2018 Oct;110(5):949-956. doi: 10.1016/j.fertnstert.2018.06.028.
Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol. 2007 Oct;9(10):1102-9. doi: 10.1038/ncb1007-1102.
Wong M, Crnobrnja B, Liberale V, Dharmarajah K, Widschwendter M, Jurkovic D. The natural history of endometrial polyps. Hum Reprod. 2017 Feb;32(2):340-345. doi: 10.1093/humrep/dew307. Epub 2016 Dec 18.
Zhang L, Liu Y, Xu Y, Wu H, Wei Z, Cao Y. The expression of the autophagy gene beclin-1 mRNA and protein in ectopic and eutopic endometrium of patients with endometriosis. Int J Fertil Steril. 2015 Jan-Mar;8(4):429-36. doi: 10.22074/ijfs.2015.4183. Epub 2015 Feb 7.
Other Identifiers
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03.09.20-08/01
Identifier Type: -
Identifier Source: org_study_id