HABIT-ILE in Infants and Toddlers With Cerebral Palsy (Baby HABIT-ILE)

NCT ID: NCT04698395

Last Updated: 2021-10-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-15

Study Completion Date

2023-12-31

Brief Summary

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Using a randomized controlled trial design, the possible changes induced by the intensive treatment programme "Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)" in functional, everyday life activities and neuroplastic assessment will be studied in infants and toddlers with cerebral palsy.

Detailed Description

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Using a randomized controlled trial design, the possible changes in neuroimaging, motor function and everyday life activities of infants and toddlers at risk of or with a diagnosis of cerebral palsy after participating of the intensive treatment programme "Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)" will be studied . Changes, scored by parents in case of questionnaires and by experts in the case of tests, will be observed comparing infants/toddlers after their regular care and after receiving HABIT-ILE. Motor function and daily life activities will be correlated with neuroplastic changes. Moreover, possible therapy onset outcomes differences will be observed.

Conditions

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Cerebral Palsy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Allocation
Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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HABIT-ILE

Baby HABIT-ILE (Hand-Arm Bimanual Intensive Therapy Including Lower Extremities) intervention during two weeks

Group Type EXPERIMENTAL

Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)

Intervention Type BEHAVIORAL

motor learning-based, intensive therapy for children with cerebral palsy

Regular care

Usual customary care intervention during two weeks

Group Type ACTIVE_COMPARATOR

Regular care

Intervention Type BEHAVIORAL

customary or usual care given to any infant/toddler with cerebral palsy

Interventions

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Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)

motor learning-based, intensive therapy for children with cerebral palsy

Intervention Type BEHAVIORAL

Regular care

customary or usual care given to any infant/toddler with cerebral palsy

Intervention Type BEHAVIORAL

Other Intervention Names

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Baby HABIT-ILE Usual care

Eligibility Criteria

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Inclusion Criteria

* children with diagnosed unilateral cerebral palsy or at risk of developing unilateral cerebral palsy or with signs of unilateral cerebral palsy
* age 8 to 18 months inclusive (corrected age if preterm birth)
* ability to follow instructions and complete testing according to the age.

Exclusion Criteria

* active seizure
* programmed botulinum toxin or orthopedic surgery in the 6 months previous to the intervention, during intervention period or 6 months after the intervention time.
* severe visual impairments
* severe cognitive impairments
* contraindications to perform magnetic image resonance (MRI) assessments (metal implants, etc.)
Minimum Eligible Age

8 Months

Maximum Eligible Age

18 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital of Mont-Godinne

OTHER

Sponsor Role collaborator

Université Catholique de Louvain

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yannick Bleyenheuft, PhD

Role: PRINCIPAL_INVESTIGATOR

MSL-IN Lab, Institute of Neuroscience, UCLouvain

Yves Vandermeeren, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Institute of Neuroscience, UCLouvain; CHU-UCL Namur, Neurology Department, UCLouvain

Locations

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Institute of Neuroscience, Université catholique de Louvain

Brussels, , Belgium

Site Status RECRUITING

Countries

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Belgium

Central Contacts

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Yannick Bleyenheuft, PhD

Role: CONTACT

+3227645446

Daniela Ebner, PhD

Role: CONTACT

+3227645446

Facility Contacts

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Yannick Bleyenheuft, Pr

Role: primary

+3227645446

Daniela Ebner, PhD

Role: backup

+3227645446

References

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Carton de Tournai A, Herman E, Ebner-Karestinos D, Gathy E, Araneda R, Renders A, De Clerck C, Kilcioglu S, Dricot L, Macq B, Vandermeeren Y, Bleyenheuft Y. Hand-Arm Bimanual Intensive Therapy Including Lower Extremities in Infants With Unilateral Cerebral Palsy: A Randomized Clinical Trial. JAMA Netw Open. 2024 Nov 4;7(11):e2445133. doi: 10.1001/jamanetworkopen.2024.45133.

Reference Type DERIVED
PMID: 39556397 (View on PubMed)

Carton de Tournai A, Herman E, Gathy E, Ebner-Karestinos D, Araneda R, Dricot L, Macq B, Vandermeeren Y, Bleyenheuft Y. Baby HABIT-ILE intervention: study protocol of a randomised controlled trial in infants aged 6-18 months with unilateral cerebral palsy. BMJ Open. 2024 Feb 17;14(2):e078383. doi: 10.1136/bmjopen-2023-078383.

Reference Type DERIVED
PMID: 38367973 (View on PubMed)

Other Identifiers

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B403201316810g

Identifier Type: -

Identifier Source: org_study_id

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