A 3 Day In-use Assessment of the Scholl Corn Foam Cushions on Pain Levels Associated With Heloma Durum.

NCT ID: NCT04695873

Last Updated: 2021-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-06-16

Study Completion Date

2021-10-11

Brief Summary

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This is an open-label, single-centre, parallel-group clinical investigation to evaluate the symptomatic pain relief, consumer acceptability and in-use tolerability of the Scholl Corn Foam Cushion in participants suffering from painful Heloma Durum over a 72-hour at home in-use period compared to a no-treatment control group.

Detailed Description

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The investigation design will include an enrolment and randomisation visit followed by an at home in-use period and a final follow up phone call. The enrolment visit will include confirmation of eligibility and collection of baseline data, including baseline pain scores using the Visual Analogue Scale (VAS), medical history, demographics, and baseline Patient Reported Outcomes (PRO) assessments. Baseline data collected will be assessed to confirm eligibility before randomisation, first product application (treatment group only), initial pain (VAS) Participant Perceived Questionnaires (PPQ) and PRO assessments. During the at home in-use period, those participants randomised to the treatment group will reapply the product daily, complete pain assessments using the VAS (morning and evening), PPQs and PROs (Day 3 evening only). For participants randomised to the no-treatment group, they will complete pain assessments using the VAS (morning and evening) and PROs (Day 3 evening). All participants will continuously record Adverse Events (AE) and changes to concomitant medication throughout this period. During the follow up phone call, the participants will be contacted to establish any further AEs and/or changes to concomitant medication, additionally any queries related to diary entries will be made during this phone call. Participants will not need to return to the site unless advised to do so by the Principal Investigator (PI) or delegate.

After completion of the investigation, the Investigator will make an Assessment of Tolerance for each subject based on their pain scores (VAS), PPQ responses and AEs reported.

Conditions

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Heloma Durum

Keywords

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VAS Pain Assessment Symptomatic Pain Relief

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

An open label, randomized parallel group, no treatment control investigation.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment Group

Foam Cushion, applied daily on Days 1, 2 and 3 of the investigation.

Group Type EXPERIMENTAL

Corn Foam Cushion

Intervention Type DEVICE

An anatomically shaped foam pad with a central hole. The upper layer is made from a honeycomb of interconnecting cells, the external facing surface is smooth, the underside is coated with adhesive.

No Treatment Group

No treatment

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Corn Foam Cushion

An anatomically shaped foam pad with a central hole. The upper layer is made from a honeycomb of interconnecting cells, the external facing surface is smooth, the underside is coated with adhesive.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Participant has provided written informed consent.
2. Male or female participants aged: ≥ 18 and \<70 years.
3. Otherwise healthy individual suffering from a single painful Heloma Durum on the dorsal digital or the plantar weight bearing area of the foot (or feet) as assessed by the Investigator or suitable delegate.
4. A baseline VAS score of ≥20 units and ≤75 units when measured on a VAS of 0-100.
5. Able to attend the investigation centre on the predefined day(s).
6. Owns or has access to a device with internet connectivity and is willing to download an investigation application and participate in the collection of patient-reported data (criterion only applicable for the use of electronic patient reported outcomes (ePRO) diary).
7. Is willing and capable of adhering to the investigational requirements.

Exclusion Criteria

1. Individuals who have known allergies or sensitivities to latex, or any other ingredients of the product, which in the opinion of the Investigator is considered clinically relevant.
2. Individuals who have received any of the following treatment of their Heloma Durum:

1. Conservative treatments (e.g. cushioning) within the last 2 days
2. Chemical treatments (e.g. Salicylic Acid plaster) within the last 2 weeks
3. Physical treatments (e.g. Heloma Durum debridement, including home debridement) within the last 6 weeks
3. Participants who, in the opinion of the Principal Investigator, have any unhealed skin at or surrounding the Heloma Durum as a result of any treatments used by the individual.
4. Significant foot deformities or inflammation (e.g. bunions, heel spurs, gout etc.).
5. Concurrent participation in another interventional clinical study/investigation, or participation within 30 days before Day 1 of this investigation.
6. Active infections of the foot or skin of the foot.
7. Those who are pregnant, attempting to become pregnant, or believe they may be pregnant or have given birth within the last 6 months (self-reported).
8. Participants who regularly use painkillers for ongoing conditions.
9. Participants who have taken over-the-counter painkillers within the last 2 days prior to screening.
10. Participants who are taking/or have taken prescription painkillers in the last 2 weeks prior to screening.
11. Participants who are unwilling to wear the same footwear throughout the investigation (footwear is defined as structured and enclosed shoes or trainers with a method of closure e.g. laces and a heel of less than 3 cm. Consistent wearing of socks/tights should be maintained throughout the investigation) for the duration of the investigation.
12. Any individuals with diabetes or poor blood circulation.
13. Any other callosity that is not identified as a Heloma Durum by a healthcare professional (i.e. soft corn, neurovascular corn, seed corn, fibrous corns).
14. Any Heloma Durum where the surrounding skin is inflamed or broken.
15. Any other features identified within the screening process that in the opinion of the Investigator will impact the safety or wellbeing of the participant or affect the outcome of the investigation.
16. Participants who are employees at the site or are a partner or first-degree relative of the Investigator.
17. Participants who fail to satisfy the Investigator of fitness to participate for any other reason
Minimum Eligible Age

18 Years

Maximum Eligible Age

69 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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O4 Research

UNKNOWN

Sponsor Role collaborator

Reckitt Benckiser Healthcare (UK) Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David Watterson

Role: PRINCIPAL_INVESTIGATOR

Moneeb Saddiq

Role: STUDY_DIRECTOR

Locations

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Podiatry Services, West Community Services

Galway, , Ireland

Site Status

Countries

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Ireland

References

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Becker BA, Childress MA. Common Foot Problems: Over-the-Counter Treatments and Home Care. Am Fam Physician. 2018 Sep 1;98(5):298-303.

Reference Type BACKGROUND
PMID: 30216025 (View on PubMed)

Booth J, Mclnnes A. The aetiology and management of plantar callus formation. J Wound Care. 1997 Oct 2;6(9):427-430. doi: 10.12968/jowc.1997.6.9.427.

Reference Type BACKGROUND
PMID: 27937673 (View on PubMed)

Burkhart CG. Skin disorders of the foot in active patients. Phys Sportsmed. 1999 Feb;27(2):88-101. doi: 10.3810/psm.1999.02.673.

Reference Type BACKGROUND
PMID: 20086699 (View on PubMed)

Devlin NJ, Shah KK, Feng Y, Mulhern B, van Hout B. Valuing health-related quality of life: An EQ-5D-5L value set for England. Health Econ. 2018 Jan;27(1):7-22. doi: 10.1002/hec.3564. Epub 2017 Aug 22.

Reference Type BACKGROUND
PMID: 28833869 (View on PubMed)

Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997 Nov;35(11):1095-108. doi: 10.1097/00005650-199711000-00002.

Reference Type BACKGROUND
PMID: 9366889 (View on PubMed)

Hodgkin SE, Hoffmann TJ, Ramsey ML. Minimizing Corns and Calluses. Phys Sportsmed. 1990 Jun;18(6):87-91. doi: 10.1080/00913847.1990.11710068.

Reference Type BACKGROUND
PMID: 27452098 (View on PubMed)

Menz HB, Zammit GV, Munteanu SE. Plantar pressures are higher under callused regions of the foot in older people. Clin Exp Dermatol. 2007 Jul;32(4):375-80. doi: 10.1111/j.1365-2230.2007.02421.x. Epub 2007 Apr 8.

Reference Type BACKGROUND
PMID: 17425648 (View on PubMed)

Omura EF, Rye B. Dermatologic disorders of the foot. Clin Sports Med. 1994 Oct;13(4):825-41.

Reference Type BACKGROUND
PMID: 7805109 (View on PubMed)

Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993 Nov;4(5):353-65. doi: 10.2165/00019053-199304050-00006.

Reference Type BACKGROUND
PMID: 10146874 (View on PubMed)

Silfverskiold JP. Common foot problems. Relieving the pain of bunions, keratoses, corns, and calluses. Postgrad Med. 1991 Apr;89(5):183-8. doi: 10.1080/00325481.1991.11700901.

Reference Type BACKGROUND
PMID: 1826149 (View on PubMed)

Rinaldi, F. & Clemente, F., 1994. The importance of formulation of a plaster containing salicylic acid in treatment of corns. Foot, The, 4(4), pp. 186-190.

Reference Type BACKGROUND

Grouios, 2004. Corns and calluses in athletes' feet: a cause for concern. Foot, The, 14(4), pp. 175-184.

Reference Type BACKGROUND

Other Identifiers

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4101101

Identifier Type: -

Identifier Source: org_study_id