Insulin Glargine U300 vs Insulin Degludec U100 in Impact on the Glycaemic and Cardiovascular Factors

NCT ID: NCT04692415

Last Updated: 2020-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-15

Study Completion Date

2019-06-27

Brief Summary

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To compare the impact of insulin degludec (IDeg-100) and insulin glargine U300 (IGlar-300) on cardiovascular risk parameters - glycaemic variability (GV), oxidative stress, arterial stiffness and lipid parameters - in insulin naive patients with DMT2.

Detailed Description

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We recruited a total of 25 patients (23 completed the study) with T2DM who had uncontrolled disease on two or more oral antidiabetic drugs. After the wash-up period, they were randomized alternately to first receive either IDeg-100 or IGlar-300 along with metformin. Each insulin was applied for 12 weeks. At the beginning and the end of each phase, biochemical and oxidative stress parameters were analysed and augmentation index was measured. On three consecutive days prior to each control point, patients performed a 7-point SMBG profile. Oxidative stress was assessed by measuring thiol groups and hydroperoxides (d-ROM) in serum. For augmentation index measuring, we used SphygmoCor (AtCor Medical, Sydney, Australia) which allow non-invasive measurement of AIx on radial artery using strain gauge transducer placed on the tip of a pencil-type tonometer. This method is based on the principle of applanation tonometry

Conditions

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Diabetes Mellitus, Type 2

Keywords

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Diabetes mellitus type 2 degludec glargine U300 glucose variability lipids arterial stiffness oxidative stress

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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degludec arm

25 patients were discontinued their previous therapy and given metformin alone (2 g/day) for seven days. After seven days they were randomized to first receive IDeg-100 In phase one they received IDeg-100 and metformin for 12 weeks. Phase one was followed by a second wash-up period in which patients received metformin alone again for seven days. In phase two, which also lasted for 12 weeks, patients were switched from IDeg-100 to IGlar-300 (and metformin was continued). The initial dose of both insulins was 0.2 IU/kg.

Group Type ACTIVE_COMPARATOR

Degludec

Intervention Type DRUG

treatment of DM and it's affect on Glycaemic Variability, Oxidative Stress, Arterial Stiffness and the Lipid Profiles

glargine arm

25 patients were discontinued their previous therapy and given metformin alone (2 g/day) for seven days. After seven days they were randomized to first receive IGlar-300 In phase one they received IGlar-300 and metformin for 12 weeks. Phase one was followed by a second wash-up period in which patients received metformin alone again for seven days. In phase two, which also lasted for 12 weeks, patients were switched from IGlar-300 to IDeg-100 (and metformin was continued). The initial dose of both insulins was 0.2 IU/kg.

Group Type ACTIVE_COMPARATOR

Glargine U300

Intervention Type DRUG

treatment of DM and it's affect on Glycaemic Variability, Oxidative Stress, Arterial Stiffness and the Lipid Profiles

Interventions

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Degludec

treatment of DM and it's affect on Glycaemic Variability, Oxidative Stress, Arterial Stiffness and the Lipid Profiles

Intervention Type DRUG

Glargine U300

treatment of DM and it's affect on Glycaemic Variability, Oxidative Stress, Arterial Stiffness and the Lipid Profiles

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* a history of DMT2 for at least 1 year
* aged between 18 and 65 years (women obligatory postmenopausal)
* uncontrolled glycaemia on two or more oral antidiabetic drugs
* no prior use of insulin
* HbA1c ≥7.5%
* receiving statins (if not on statins, they were put on it)
* not on antiaggregant therapy (if on antiaggregants, they were temporarily excluded from therapy)

Exclusion Criteria

* the presence of malignant disease
* chronic liver disease
* renal impairment with creatinine clearance \< 60 ml/s
* severe cardiovascular disease or history of cardiovascular incidents (stroke, myocardial infarction, peripheral amputation)
* rheumatic and autoimmune diseases and the usage of glitazones or anticoagulant therapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pavle Vrebalov Cindro

UNKNOWN

Sponsor Role collaborator

Jonatan Vuković

UNKNOWN

Sponsor Role collaborator

Darko Modun

UNKNOWN

Sponsor Role collaborator

Božo Smajić

UNKNOWN

Sponsor Role collaborator

Gordan Kardum

UNKNOWN

Sponsor Role collaborator

Tina Tičinović Kurir

UNKNOWN

Sponsor Role collaborator

Doris Rušić

UNKNOWN

Sponsor Role collaborator

Ana Šešelja Perišin

UNKNOWN

Sponsor Role collaborator

Josipa Bukić

UNKNOWN

Sponsor Role collaborator

University of Split, School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Mladen Krnic

Assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Klinički bolnički Centar Split

Split, , Croatia

Site Status

Countries

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Croatia

References

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Other Identifiers

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500-03/16-01/49

Identifier Type: -

Identifier Source: org_study_id