A Study to Compare PK, PD and Safety of the AD-213-A and AD-2131

NCT ID: NCT04690868

Last Updated: 2022-04-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-10-15

Study Completion Date

2021-12-21

Brief Summary

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A study to compare safety, pharmacokinetics and pharmacodynamics of AD-213-A to AD-2131 in healthy volunteers.

Detailed Description

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Conditions

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Gastroesophagus Reflux Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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ARM 1

Period 1 : Reference Drug(AD-2131) Period 2 : Test Drug(AD-213-A)

Group Type EXPERIMENTAL

AD-213-A

Intervention Type DRUG

1 tablet administered before the breakfast during 5 days

AD-2131

Intervention Type DRUG

1 tablet administered before the breakfast during 5 days

ARM 2

Period 1 : Test Drug(AD-213-A) Period 2 : Reference Drug(AD-2131)

Group Type EXPERIMENTAL

AD-213-A

Intervention Type DRUG

1 tablet administered before the breakfast during 5 days

AD-2131

Intervention Type DRUG

1 tablet administered before the breakfast during 5 days

Interventions

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AD-213-A

1 tablet administered before the breakfast during 5 days

Intervention Type DRUG

AD-2131

1 tablet administered before the breakfast during 5 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy adults over 19 years of age.
* Weight is more than 50kg and BMI is more than 18.0 kg/m\^2 , no more than 27.0 kg/m\^2.
* Subject who has been judged to be eligible for clinical laboratory tests and electrocardiogram tests such as serum tests, hematology tests, blood chemistry tests, and urinary tests conducted within four weeks prior to the administration of clinical trials.
* Subjects who has heard and fully understood the detailed description of this clinical trial and have willingness to sign of informed consent in writing.

Exclusion Criteria

* A subject who has a history that can affect the absorption, distribution, metabolism, or excretion of a drug.
* As a result of laboratory tests, the following figures: ALT or AST or total bilirubin \> 1.5 times upper limit of normal range.
* As a result of laboratory tests, the following figures: Creatinine clearance \< 80mL/min.
* Subjects who judged ineligible by the investigator.
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Addpharma Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kyungpook National University Hospital

Daegu, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AD-213PK/PD

Identifier Type: -

Identifier Source: org_study_id

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