Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
EARLY_PHASE1
120 participants
INTERVENTIONAL
2021-01-06
2022-02-22
Brief Summary
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paracetamol is an antipyretic drug that has been in clinical use for a long time.
It can lower the BT of febrile and nonfebrile patients. A previous study demonstrated that orally administered paracetamol can suppress in a dose-dependent manner the increase in the BT of patients with acute ischemic stroke. However, few studies have evaluated the effects of paracetamol on postoperative shivering.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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saline group
normal saline
received intravenous 0.9% normal saline over a 15-minute period.
ondansetron group
ondansetron
received intravenous 8 mg of ondansetron over a 15-minute period.
paracetamol group
paracetamol
received intravenous one gram of paracetamol over a 15-minute period,
Interventions
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paracetamol
received intravenous one gram of paracetamol over a 15-minute period,
ondansetron
received intravenous 8 mg of ondansetron over a 15-minute period.
normal saline
received intravenous 0.9% normal saline over a 15-minute period.
Eligibility Criteria
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Inclusion Criteria
* ASA physical status I and II
* Both genders
* Patients scheduled for elective mega-liposuction surgery under combined general epidural anesthesia
Exclusion Criteria
* ASA physical status more than II,
* any contraindications to regional anesthesia,
* surgical duration less than two hours or exceeding six hours,
* giving history of any of the following; allergy to the study medications used, system impairment, alcohol abuse, any endocrine disease affecting body temperature such as thyroid disorders,
* any psychiatric or neurological disorders, convulsions, patient receiving vasodilators or medications likely to alter thermoregulation,
* Finally if their body temperature was recorded to surpass 37.5ºC or \<36.5°C before enrolment.
18 Years
40 Years
ALL
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Amr Samir Wahdan
Lecturer of Anesthesia, Pain management and Surgical ICU
Locations
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Cairo university
Cairo, , Egypt
Countries
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Other Identifiers
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N-122-2020
Identifier Type: -
Identifier Source: org_study_id
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