Wound Contamination During Orthopaedic Surgery

NCT ID: NCT04676841

Last Updated: 2020-12-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-01

Study Completion Date

2022-11-30

Brief Summary

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In the present study we will compare bacteriological findings and the incidence of SSI in relation to laminar airflow (LAF) ventilated ORs, conventional (also called displacement or mixed) ventilated ORs and conventional ventilated ORs with the addition of tables equipped with units providing a local LAF over the surgical instruments.

The hypothesis is that there exist a correlation between number and types of airborne bacteria and bacteria in the surgical wound and on surgical instruments at the time of wound closure.

Detailed Description

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The scientific literature on the relationship between airborne bacteria and wound contamination during different conditions is scares. A study from 1982 (Whyet et al.), demonstrated that the most important and consistent source of contamination of the wound during clean surgery (in this case hip implant surgery) was via air. The study concluded that approximately one third of bacteria in the wound were caused by direct air contamination whereas the remaining number of bacteria were transferred to the wound by indirect routes such as via contaminated instruments.

The present study includes patients undergoing hemiarthroplastic surgery due to hip fracture.

During the surgery active air sampling, for microbial analysis, will be done within 30 cm from the wound.

Passive sampling of instrument tables, to measure number of depositing bacteria on the surface during the procedure, will be performed by placing sterile filters on the table surfaces before initiating the surgical procedure and collecting them at the end.

Skin and wound sampling will be performed with sterile flocked nylon swabs. The method for skin and wound sampling was decided based on a literature review and discussions with the department of Clinical microbiology at Sahlgrenska University hospital. Both aerobe and anaerobe bacteria will be analyzed.

The wound will be measured and number of personnel, door openings and clothing, at each procedure will be recorded.

Patients included in the study will be interviewed after 6 weeks and 1 year, to evaluate incidence rate of SSI.

Conditions

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Surgical Site Infection Hip Fractures Orthopedic Disorder Implant Infection

Keywords

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LAF UDF SSI Wound contamination Infection control Airborne contamination Operating room

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Hemiarthroplasty

Hip fracture patients operated with hemiarthroplasty

Conventional ventilation + instrumental tables with integrated laminar airflow

Intervention Type DEVICE

Surgical instruments protected from contamination by local laminar airflow

Conventional ventilation + standard instrumental tables

Intervention Type DEVICE

Control

Laminar airflow ventilation + standard instrumental tables

Intervention Type DEVICE

Control

Interventions

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Conventional ventilation + instrumental tables with integrated laminar airflow

Surgical instruments protected from contamination by local laminar airflow

Intervention Type DEVICE

Conventional ventilation + standard instrumental tables

Control

Intervention Type DEVICE

Laminar airflow ventilation + standard instrumental tables

Control

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients undergoing hip fracture surgery treated with hemiarthroplasty implant and that are subsequently cared for at participating ortho-geriatric unit

Exclusion Criteria

* Patients that will not give their informed consent.
* Patient that, at the time of surgery, have an infection in any part of the body, hospital or community acquired.
* Patients receiving fracture fixation with pins only
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Research Institutes of Sweden

OTHER

Sponsor Role collaborator

Göteborg University

OTHER

Sponsor Role collaborator

CRC Medical AB

UNKNOWN

Sponsor Role collaborator

Getinge AB

UNKNOWN

Sponsor Role collaborator

Toul Meditech AB

UNKNOWN

Sponsor Role collaborator

Halmstad University

OTHER

Sponsor Role collaborator

Vastra Gotaland Region

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Henrik Malchau

Role: PRINCIPAL_INVESTIGATOR

Sahlgrenska University Hospital

Locations

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Department of Ortopedics, Sahlgrenska University Hospital

Mölndal, , Sweden

Site Status RECRUITING

Countries

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Sweden

Central Contacts

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Annette Erichsen Andersson

Role: CONTACT

Phone: +46 73 725 04 58

Email: [email protected]

Henrik Malchau

Role: CONTACT

Phone: +46 70 820 76 51

Email: [email protected]

Facility Contacts

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Annette Erichsen Andersson

Role: primary

Other Identifiers

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2019-02180

Identifier Type: -

Identifier Source: org_study_id