Scan-rescan Reproducibility of Myelin Sensitive MRI Techniques
NCT ID: NCT04673734
Last Updated: 2021-12-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
13 participants
OBSERVATIONAL
2021-02-05
2021-09-30
Brief Summary
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Detailed Description
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Multi-echo Susceptibility-Based imaging (SBI) provides quantitative susceptibility maps and T2\* maps that - when combined - permit the disentanglement of myelin from iron and various phases of myelin degradation.
Myelin Water Imaging (MWI) quantifies the water trapped between myelin layers by separating the multiple water components in T2 relaxometry data. In fact, the presence of myelin on water pools bound to it provokes a loss in magnetic resonance (MR)-signal coherence, which is more rapid than the one characterizing the water pools located within the axons or in the cytoplasm.
A method based on a spiral acquisition that achieves a myelin-specific signal in clinically compatible scan times is currently applied: T1 relaxometry (quantitative T1, qT1) - which measures the time that a perturbed nuclear spin distribution needs to get back to equilibrium in the longitudinal plane- is sensitive to a number of components of the brain tissue such as myelin, axonal diameter and the overall architectural organization of the brain tissue.
Finally, multi-shell diffusion allows the application of mathematical models of diffusion compartments, which in part are influenced by myelin integrity.
The goal of this study is to assess the stability of these techniques in scan-rescan experiment on 20 healthy subjects.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Interventions
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myelin sensitive MRI scan
Acquisition of 3 myelin sensitive MRI scans as follows: 1. Two MRI during 1 day; the second after 30 min interval and a repositioning.
2\. One MRI within one week after the first one.
The total scan time will be \~ 1 hour. T1 maps will be calculated after magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE6) acquisition based on a product sequence. Magnetization Transfer (MT) sat maps will be calculated. Quantitative susceptibility mapping (QSM) maps will be reconstructed using an in-house implementation of the structural feature based collaborative reconstruction algorithm (SFCR). For the reconstruction of multi-shell diffusion data, AMICO10 Accelerated Microstructure Imaging via Convex Optimization (AMICO) from diffusion MRI data will be used. Myelin Water Fraction maps will be fitted voxel-wise using a Non-Negative Least Squares fitting.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).
* Inability to give consent.
18 Years
80 Years
ALL
Yes
Sponsors
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Hoffmann-La Roche
INDUSTRY
University Hospital, Basel, Switzerland
OTHER
Responsible Party
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Principal Investigators
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Cristina Granziera, Prof. Dr. med.
Role: PRINCIPAL_INVESTIGATOR
Neurologische Klinik und Poliklinik, University Hospital Basel
Locations
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Neurologische Klinik und Poliklinik, University Hospital Basel
Basel, , Switzerland
Countries
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Other Identifiers
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2020-02826; me20Granziera3
Identifier Type: -
Identifier Source: org_study_id