The Effect of Chewing the Tapioca Pearls in Bubble Tea Drinks

NCT ID: NCT04670341

Last Updated: 2020-12-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-17

Study Completion Date

2020-10-17

Brief Summary

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Bubble tea drinks contain tea and tapioca pearls. Chewing tapioca pearls in bubble tea drinks may increase salivary components. Because of its proteins, inorganic components, and enzymes, saliva plays an important role in the body's defense against bacteria and viruses. This study aims to analyze the effect of chewing the tapioca pearls in bubble tea drinks on salivary C-reactive protein (CRP) and calcium (Ca) levels.

Detailed Description

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Sixty saliva samples were collected from 15 subjects. The inclusion criterion was 18-25 years of age. The exclusion criteria were receiving medication, using dentures, a history of dry mouth, smoking and systemic disease. In the first week of the experiment, subjects drank bubble tea as the intervention group. In the second week, the same subjects drank tea without pearls as the control group. Each subject drank the bubble tea for 5 minutes per day over 3 days. Saliva samples were collected on the first day before bubble tea consumption (pretest) and on the third day after tea consumption (posttest). Saliva collection was performed in the morning (09:00 a.m.-12:00 p.m.) for 1 minute. Salivary CRP levels were measured using an ELISA kit, and Ca levels were determined using a test kit.

Conditions

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Saliva

Keywords

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bubble tea salivary C-reactive protein salivary calcium

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

In the first week of the experiment, subject chewing tapioca pearl inthe bubble tea. In the second week, the same subjects drink tea without chewing tapioca pearl
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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chewing tapioca pearls in the bubble tea drinks

In the first week, the subjects drink as much as 100 ml of bubble tea over a span of 5 minutes once a day for 3 days

Group Type EXPERIMENTAL

chewing tapioca pearls in bubble tea drinks

Intervention Type OTHER

Saliva was collected on the first day before bubble tea consumption (pretest) and on the third day after bubble tea consumption (posttest); collection was conducted in the morning (09:00 a.m.-12.00 p.m.).

drink tea without chewing tapioca pearls

In the second week, the subjects drink tea without tapioca pearls as much as 100 ml for 5 minutes per day for 3 days.

Group Type PLACEBO_COMPARATOR

drink tea without chewing tapioca pearls

Intervention Type OTHER

Saliva was collected on the first day before drink tea without tapioca pearl (pretest) and on the third day after tea consumption (posttest); collection was conducted in the morning (09:00 a.m.-12.00 p.m.).

Interventions

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chewing tapioca pearls in bubble tea drinks

Saliva was collected on the first day before bubble tea consumption (pretest) and on the third day after bubble tea consumption (posttest); collection was conducted in the morning (09:00 a.m.-12.00 p.m.).

Intervention Type OTHER

drink tea without chewing tapioca pearls

Saliva was collected on the first day before drink tea without tapioca pearl (pretest) and on the third day after tea consumption (posttest); collection was conducted in the morning (09:00 a.m.-12.00 p.m.).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* good Oral Hygiene Index-Simplified (OHI-S) score

Exclusion Criteria

* taking medication
* a history of dry mouth
* smoking
* systemic disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

25 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Gadjah Mada University

OTHER

Sponsor Role lead

Responsible Party

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Juni Handajani

Quality improvement of saliva by chewing tapioca pearls in bubble tea drinks

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Juni Handajani, PhD

Role: PRINCIPAL_INVESTIGATOR

Faculty of Dentistry, Universitas Gadjah Mada

Locations

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Faculty of Dentistry, Universitas Gadjah Mada

Yogyakarta, , Indonesia

Site Status

Countries

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Indonesia

References

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Handajani J, Kusumajati D, Fathiyah H, Susilowati H, Tandelilin RTC. Quality improvement of saliva by chewing tapioca pearls in bubble tea drinks: a randomized experimental trial: (Study on salivary C-reactive protein (CRP) and calcium (Ca) levels). F1000Res. 2021 Feb 1;10:56. doi: 10.12688/f1000research.28028.2. eCollection 2021.

Reference Type DERIVED
PMID: 35387272 (View on PubMed)

Related Links

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https://doi.org/10.1186/1476-9255-8-37

Elevated salivary C-reactive protein levels are associated with active and passive smoking in healthy youth: A pilot study

Other Identifiers

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FKGUGM1

Identifier Type: -

Identifier Source: org_study_id