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National Bacterial Meningitis Study

NCT ID: NCT04664569

Last Updated: 2022-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

8230 participants

Study Classification

OBSERVATIONAL

Study Start Date

2001-01-01

Study Completion Date

2030-01-01

Brief Summary

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Bacterial meningitis is a major cause of morbidity and mortality in childhood. Antibiotic treatment recommendations are based on epidemiological and susceptibility data. The epidemiology of bacterialméningitis has changed in recent years, mainly owing to widespread use of different conjugate vaccines. The aim of this prospective national survey is to describe epidemiology of bacteria implicated in bacterial meningitis in children.

Detailed Description

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Conditions

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Meningitis Children, Only Pneumococcal Conjugate Vaccine Meningococcal Vaccines H. Influenzae Vaccine Neonatal Infection Antibiotic Treatment Case Fatality Rate

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Cohort of bacterial meningitis in children

observational study

Intervention Type OTHER

observational study

Interventions

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observational study

observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* clinical signs of meningitis, associated with positive cerebrospinal fluid (CSF) culture and/or positive CSF antigen testing (Escherichia coli K1, N. meningitidis serogroups B, A, C, Y and W-135, group B streptococci, Hib, or S. pneumoniae), and/or positive CSF polymerase chain reaction (PCR), and/or positive blood culture with CSF pleocytosis (\> 10 cells/µL).
* purpura fulminans

Exclusion Criteria

\-
Minimum Eligible Age

0 Years

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pfizer

INDUSTRY

Sponsor Role collaborator

Association Clinique Thérapeutique Infantile du val de Marne

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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ACTIV

Créteil, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Corinne Levy, MD

Role: CONTACT

Phone: 0033148850404

Email: [email protected]

Facility Contacts

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Corinne Levy, MD

Role: primary

Stéphane Béchet, MSc

Role: backup

References

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Fafi I, Cohen R, Levy C, Varon E, Amor-Chelihi L, Benhaim P, Houlier M, Koehl B, De Montalembert M, Allali S, Gauthier A, Odievre MH, Gajdos V, Escoda S, Kamdem A, Costa G, Guillaumat C, Thuret I, Ouldali N, Gaschignard J, Carbonnelle E, De Pontual L, Pham LL. High Mortality Due to Pneumococcal Meningitis in Children With Sickle Cell Disease: A French Multicenter Observational Study From 2001 to 2021. Pediatr Infect Dis J. 2025 Jun 1;44(6):496-502. doi: 10.1097/INF.0000000000004755. Epub 2025 Mar 7.

Reference Type DERIVED
PMID: 40063777 (View on PubMed)

Rybak A, Ouldali N, Varon E, Taha MK, Bonacorsi S, Bechet S, Angoulvant F, Cohen R, Levy C; French Pediatric Meningitis Network. Vaccine-preventable Pediatric Acute Bacterial Meningitis in France: A Time Series Analysis of a 19-Year Prospective National Surveillance Network. Pediatr Infect Dis J. 2024 Jan 1;43(1):74-83. doi: 10.1097/INF.0000000000004134. Epub 2023 Nov 13.

Reference Type DERIVED
PMID: 38108805 (View on PubMed)

Related Links

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https://pubmed.ncbi.nlm.nih.gov/31220046/

Recurrent Pneumococcal Meningitis in Children: A Multicenter Case-control Study

https://pubmed.ncbi.nlm.nih.gov/30049623/

Incidence of paediatric pneumococcal meningitis and emergence of new serotypes: a time-series analysis of a 16-year French national survey

https://pubmed.ncbi.nlm.nih.gov/29045606/

Clinical and Laboratory Features of Group B Streptococcus Meningitis in Infants and Newborns: Study of 848 Cases in France, 2001-2014

https://pubmed.ncbi.nlm.nih.gov/28403047/

Risk Factors in Children Older Than 5 Years With Pneumococcal Meningitis: Data From a National Network

https://pubmed.ncbi.nlm.nih.gov/27753774/

Neonatal Meningococcal Meningitis In France From 2001 To 2013

https://pubmed.ncbi.nlm.nih.gov/27595445/

Comparative impact of pneumococcal conjugate vaccines on pneumococcal meningitis according to underlying conditions

https://pubmed.ncbi.nlm.nih.gov/27020729/

Outcomes of bacterial meningitis in children

Other Identifiers

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Obs meningitis

Identifier Type: -

Identifier Source: org_study_id