Digital Adherence Monitoring of Inhalative Therapy in Real- Life Conditions

NCT ID: NCT04656223

Last Updated: 2024-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

434 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-17

Study Completion Date

2023-01-20

Brief Summary

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This study is designed as a multicenter, observational, non-interventional, open label, 26-week study in order to observe how asthma control changes under treatment with Mometasone Fuorat/Indacaterol/ Glycopyrronium (MF/IND/GLY) Breezhaler® sensor system or under treatment with fixed-dose combination (FDC) triple therapy after 26 weeks of treatment.

Detailed Description

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Subjects in one group will receive MF/IND/GLY together with the Propeller add-on sensor for the Breezhaler® and access to the smartphone app according to label. Subjects in the other group will receive any triple FDC according to label. The physician's decision to initiate or switch a patient to MF/IND/GLY Breezhaler® system or any other triple FDC must have been taken prior to and independently from the decision to include the patient in the study.

Conditions

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Asthma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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MF/IND/GLY Breezhaler® plus Propeller Health

patients receiving MF/IND/GLY Breezhaler® plus electronic inhalation tracking sensor (Propeller Health) according to label

MF/IND/GLY plus sensor system

Intervention Type COMBINATION_PRODUCT

There is no treatment allocation. Patients administered MF/IND/GLY plus sensor system by prescription that have started before inclusion of the patient into the study will be enrolled.

Subjects will receive MF/IND/GLY together with the Propeller add-on sensor for the Breezhaler® according to label.

Other FDC therapy

patients receiving ICS+LABA+LAMA FDC therapy according to label

FDC therapy

Intervention Type DRUG

There is no treatment allocation. Patients administered FDC therapy by prescription that have started before inclusion of the patient into the study will be enrolled.

Interventions

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MF/IND/GLY plus sensor system

There is no treatment allocation. Patients administered MF/IND/GLY plus sensor system by prescription that have started before inclusion of the patient into the study will be enrolled.

Subjects will receive MF/IND/GLY together with the Propeller add-on sensor for the Breezhaler® according to label.

Intervention Type COMBINATION_PRODUCT

FDC therapy

There is no treatment allocation. Patients administered FDC therapy by prescription that have started before inclusion of the patient into the study will be enrolled.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

1. Patients (m/f/d) at the age of ≥18
2. Written declaration of consent
3. Asthma diagnosis according to German Asthma Guideline NVL, 4th edition
4. Suitability for a therapy with MF/IND/GLY in combination with the sensor system or another ICS+LABA+LAMA FDC according to SPC
5. At least 6 months of inhaled therapy with ICS+LABA (high dose) or ICS+LABA+LAMA (medium or high dose) before switching or escalating asthma medication at baseline
6. Change or escalation of the asthma medication to MF/IND/GLY in combination with the sensor system or another ICS+LABA+LAMA FDC according to the therapy decision of the treating physician
7. Availability of at least one ACT value of the last 6 months before consent
8. Cohort treated with MF/IND/GLY in combination with the sensor system

* Owning an Android or iOS smartphone or tablet on which the app can be installed (via WiFi or mobile data network) and run (requires about 75 megabytes of storage space) and which is capable of establishing a Bluetooth connection to the sensor The patient must agree to activate the app, the Bluetooth connection and the mobile data connection regularly (at least once a month).
* Availability of an e-mail address

Exclusion Criteria

1. Use of a digital inhaler-coupled inhalation tracking system to support adherence in the last 3 months prior to study entry
2. Simultaneous participation in an interventional study or in another Novartis-sponsored noninterventional study
3. Asthma therapy with a biological agent, if not stable at the same dosage for at least 3 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_DIRECTOR

Novartis Pharmaceuticals

Locations

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Novartis Investigative Site

Ulm, Baden-Wurttemberg, Germany

Site Status

Novartis Investigative Site

Braunschweig, Lower Saxonia, Germany

Site Status

Novartis Investigative Site

Hanover, Lower Saxonia, Germany

Site Status

Novartis Investigative Site

Ibbenbueren, Rhineland-Palatinate, Germany

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Novartis Investigative Site

Leipzig, Saxony, Germany

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Novartis Investigative Site

Ansbach, , Germany

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Novartis Investigative Site

Aschaffenburg, , Germany

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Novartis Investigative Site

Augsburg, , Germany

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Novartis Investigative Site

Bad Sachsa, , Germany

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Novartis Investigative Site

Berlin, , Germany

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Novartis Investigative Site

Berlin, , Germany

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Novartis Investigative Site

Berlin, , Germany

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Novartis Investigative Site

Berlin, , Germany

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Novartis Investigative Site

Burgwedel, , Germany

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Novartis Investigative Site

Einbeck, , Germany

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Novartis Investigative Site

Fürstenwalde, , Germany

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Novartis Investigative Site

Göttingen, , Germany

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Novartis Investigative Site

Hamburg, , Germany

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Novartis Investigative Site

Hanover, , Germany

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Leipzig, , Germany

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Leipzig, , Germany

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Novartis Investigative Site

Marburg, , Germany

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Novartis Investigative Site

Markkleeberg, , Germany

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Novartis Investigative Site

Papenburg, , Germany

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Novartis Investigative Site

Radebeul, , Germany

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Novartis Investigative Site

Wiesbaden, , Germany

Site Status

Countries

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Germany

Related Links

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https://www.novctrd.com/ctrdweb/trialresult/trialresults/pdf?trialResultId=18137

Results for CQVM149BDE01 that is getting linked from the Novartis Clinical Trials Website

Other Identifiers

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CQVM149BDE01

Identifier Type: -

Identifier Source: org_study_id

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